Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mandar Bawadekar"'
Autor:
Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. However, the importance
Externí odkaz:
https://doaj.org/article/6fd59b6353344d72996e41b25de3b5fa
Autor:
Peter Lamb, Seema Kantak, Bryan Glaser, Justin Wetter, Bee-Cheng Sim, Jeff Higaki, Jacob Beal, Sara Ollerman, Dileep Pulukkunat, Mandar Bawadekar, Charles Kaplan, Bonnie Hammer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/1667f5e92ad147a390c033bc9d07eb14
Autor:
Dres Damgaard, Mandar Bawadekar, Ladislav Senolt, Allan Stensballe, Miriam A Shelef, Claus H Nielsen
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203214 (2018)
OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs). Little
Externí odkaz:
https://doaj.org/article/9ff6b1964fac487fa951d1f17ddf758e
Autor:
Aisha M. Mergaert, Mandar Bawadekar, Thai Q. Nguyen, Laura Massarenti, Caitlyn L. Holmes, Ryan Rebernick, Steven J. Schrodi, Miriam A. Shelef
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3093 (2019)
Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to
Externí odkaz:
https://doaj.org/article/6b929deed394480a8097cdd0c48eedb1
Autor:
Francesca Gugliesi, Mandar Bawadekar, Marco De Andrea, Valentina Dell'Oste, Valeria Caneparo, Angela Tincani, Marisa Gariglio, Santo Landolfo
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63045 (2013)
IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions. It is also a target for autoantibodies as specific antibodies have been demonstrated in the sera of patients affec
Externí odkaz:
https://doaj.org/article/58d62f1401d740799cf6e87c24aef25b
Autor:
Justin Wetter, Bonnie Hammer, Bryan Glaser, Charles Kaplan, Sara Ollerman, Peter Lamb, Jeff Higaki, Mandar Bawadekar, Bee-Cheng Sim, Pulukkunat Dileep Kumar, Seema Kantak, Jacob Beal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Tumor cells have been shown to utilize both innate and adaptive checkpoints to evade anti-tumor immune responses. CD47 and PD-L1 are two targets widely expressed on the cell surface of tumor cells and are predicted to coordinately suppress
Autor:
Chad J. Johnson, Miriam A. Shelef, Mandar Bawadekar, Jeniel E. Nett, Thomas F. Warner, Claus Henrik Nielsen, Dres Damgaard, Daeun Shim, Ger J. M. Pruijn, Ryan Rebernick
Publikováno v:
Journal of Autoimmunity, 80, pp. 39-47
Journal of Autoimmunity, 80, 39-47
Journal of Autoimmunity, 80, 39-47
Citrullination, the post-translational conversion of arginines to citrullines, may contribute to rheumatoid arthritis development given the generation of anti-citrullinated protein antibodies (ACPAs). However, it is not known which peptidylarginine d
Autor:
Caitlyn L. Holmes, Laura Massarenti, Ryan Rebernick, Aisha M Mergaert, Miriam A. Shelef, Steven J. Schrodi, Mandar Bawadekar, Thai Q Nguyen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3093 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 12
International Journal of Molecular Sciences
Volume 20
Issue 12
Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to
Autor:
Bo Sun, Paul R. Thompson, Ari J. Salinger, Eranthie Weerapana, Hui-Hsin Chang, Miriam A. Shelef, Mandar Bawadekar, Caitlyn L. Holmes, Beverly Tomita, I-Cheng Ho
Publikováno v:
JCI insight. 4(22)
Dysregulated citrullination, a unique form of posttranslational modification catalyzed by the peptidylarginine deiminases (PADs), has been observed in several human diseases, including rheumatoid arthritis. However, the physiological roles of PADs in
Autor:
Miriam A. Shelef, Christie M. Bartels, Ryan Rebernick, Nicole Rademacher, Lauren M Fahmy, Christopher R. Glover, Daeun Shim, Hemanth Potluri, Caitlyn L. Holmes, Mandar Bawadekar
Publikováno v:
Biological Procedures
Background Neutrophil extracellular traps (NETs), extracellular structures composed of decondensed chromatin and antimicrobial molecules, are released in a process called NETosis. NETs, which are part of normal host defense, have also been implicated