Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mandar, Bhonde"'
Autor:
Charudatt Samant, Ramesh Kale, Anand Bokare, Mahip Verma, K. Sreedhara Ranganath Pai, Mandar Bhonde
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101544- (2023)
Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most difficult to treat cancers. Gemcitabine is still the standard of care treatment for PDAC but with modest survival benefit and well reported resistance. Here we explored potential of inhi
Externí odkaz:
https://doaj.org/article/5db77965839447f49e57f711cfccf995
Autor:
Mahip K. Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Milind K. Gholve, Ajitkumar Marisetti, Brahmam Sunkara, Aditya Naik, Manisha Shingare, Madhusudhan Reddy, Anand M. Bokare, Atul Akarte, Sarita Koul, Prashant B. Nigade, Vinod B. Patil, Dipak Modi, Prajakta Ahirrao, Shashikant Pawar, Sandip Kuldharan, Lal Dinchhana, Maneesh Mehta, Jayasagar Gundu, Nirmal Jana, Prashant Vidhate, Sachin Jaysing Mahangare, Manojkumar R. Shukla, Rajan N. Goel, Mandar Bhonde, Rajender Kumar Kamboj, Venkata P. Palle
Publikováno v:
Biochemical and Biophysical Research Communications. 637:267-275
Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression or overactivation of PI3Kδ is crucial for B-cell malignancies such as diffuse large B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4587d39fd2411d176cb38bbd74a04cae
https://doi.org/10.1016/j.bbrc.2022.11.038
https://doi.org/10.1016/j.bbrc.2022.11.038
Autor:
Shashikant Pawar, Vinod Patil, Rajender Kumar Kamboj, Milind Sindkhedkar, Trupti Bhankhede, Venkata P. Palle, Jaysagar Gundu, Spinvin Venugopal, Dhananjay Bakhle, Praveenkumar Anidil Kizhakinagath, Kumar Naik, Sanjay Bokan, Zubair Shaikh, Sagar Budhe, Vikas Shinde, Dipak Modi, M. K. Singh, Maneesh Mehta, Kamlesh J Padiya, Gururaj Vishwase, Akshaya Wagh, Rajesh Gupta, Sharad Sharma, Hemant Kumar, Sandip Kuldharan, Sadanand Mallurwar, Neelima Sinha, Gokul Deshmukh, Kaustubh Tamane, Himani Pareek, Rajesh Yeshodharan, Prashant B. Nigade, Milind Gholve, Kumar V S Nemmani, Santosh Jachak, Dilip Pandey, Nidhi Sharma, Vijay Karche, Lakshmi Narasimham, Nageswara Rao Irlapatti, Jagadeesh Daler, Rajesh Shankar, Nilesh Raghunath Khedkar, Mandar Bhonde, Vijay Kanoje, Prabakaran Kamalakannan, Chirag Shah, Shaji K George, Sachin Ingawale, Prajakta Ahirrao, Disha Dadke, Harshal Narendra Nemade, Anil Kalia, Amit Patil, Samiron Phukan, Swaroop Kumar
Publikováno v:
Journal of Medicinal Chemistry. 64:17004-17030
The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c7afc213cb2f010008814556ab51c
https://doi.org/10.1021/acs.jmedchem.1c01403
https://doi.org/10.1021/acs.jmedchem.1c01403
Autor:
Anand Tarage, Gopal Gole, Mandar Bhonde, Madhusudhan Reddy, Sharad Sharma, Harish Volam, Sudeep Sabde, Sanjeev Anant Kulkarni, Sadanand Mallurwar, Brahmam Sunkara, Ramesh Dattatraya Phadtare, Manoj Dandekar, Hemant Goyal, Samiron Phukan, Gayathri Sadasivam, Rupesh Kanhere, Maneesh Mehta, Nirmal Jana, Murthy Cheemala, Prashant Vidhate, Lal Dinchhana, Prashant B. Nigade, Bernstein Peter Robert, Prajakta Ahirrao, Rajan Goel, Aditya Naik, Vipul Pachpute, Sukanya Patra, Rajender Kumar Kamboj, Nilesh Mahajan, Kaustubh Tamane, Sneha Trivedi, M. K. Singh, Ajit Kumar Marisetti, Shankar Bhagwat, Mahip Verma, Atul Akarte, Dipak Lagad, Charudatt Samant, Venkata P. Palle, Vinod Patil, Anand Bokare, Dipak Modi, Chaitanya A. Kulkarni, Lakshmi Narasimham, Neetinkumar Reddy, Majid Bashir Sayyed, Sarita Koul, Shukla Manojkumar Ramprasad, Milind Gholve, Swati Tota, Vinod D. Chaudhari, Jayasagar Gundu, Manisha Shingare, Sachin J Mahangare, Shashikant Pawar
Publikováno v:
Journal of Medicinal Chemistry. 63:14700-14723
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4614f9af4bf378b9f2f87f030837f97
https://doi.org/10.1021/acs.jmedchem.0c01264
https://doi.org/10.1021/acs.jmedchem.0c01264
Autor:
Nilesh Raghunath, Khedkar, Nageswara Rao, Irlapatti, Disha, Dadke, Vijay, Kanoje, Zubair, Shaikh, Vijay, Karche, Vikas, Shinde, Gokul, Deshmukh, Amit, Patil, Santosh, Jachak, Samiron, Phukan, Praveenkumar Anidil, Kizhakinagath, Milind, Gholve, Trupti, Bhankhede, Jagadeesh, Daler, Harshal Narendra, Nemade, Sagar, Budhe, Himani, Pareek, Rajesh, Yeshodharan, Rajesh, Gupta, Anil, Kalia, Dilip, Pandey, Akshaya, Wagh, Swaroop, Kumar, Vinod, Patil, Dipak, Modi, Nidhi, Sharma, Prajakta, Ahirrao, Maneesh, Mehta, Hemant, Kumar, Prashant, Nigade, Kaustubh, Tamane, Sadanand, Mallurwar, Sandip, Kuldharan, Shashikant, Pawar, Gururaj, Vishwase, Sanjay, Bokan, Minakshi, Singh, Kumar, Naik, Sachin, Ingawale, Rajesh, Shankar, Prabakaran, Kamalakannan, Spinvin, Venugopal, Shaji K, George, Kamlesh J, Padiya, Kumar V S, Nemmani, Jaysagar, Gundu, Mandar, Bhonde, Lakshmi, Narasimham, Milind, Sindkhedkar, Chirag, Shah, Neelima, Sinha, Sharad, Sharma, Dhananjay, Bakhle, Rajender Kumar, Kamboj, Venkata P, Palle
Publikováno v:
Journal of medicinal chemistry. 64(23)
The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caffeb96f8b24d3487ac270d9338a645
https://pubmed.ncbi.nlm.nih.gov/34843241
https://pubmed.ncbi.nlm.nih.gov/34843241
Autor:
Vijay Kanoje, Dilip Pandey, Akshaya Wagh, Sukanya Patra, Ajit Kumar Marisetti, Madhusudhan Reddy, Charudatt Samant, Nilesh Mahajan, Milind Gholve, Sudeep Sabde, Sneha Trivedi, Trupti Bhankhede, Vinod Patil, Prashant Nigade, Dipak Modi, Maneesh Mehta, Prajakta Ahirrao, Swathi Tota, Bidyut Nanda, Shashikant Pawar, Anuradha Polawar, Kaustubh Tamane, Sandip Kuldharan, Gururaj Vishwase, Nirmal Jana, Sachin J. Mahangare, Prashant Vidhate, Dipak Lagad, Jayasagar Gundu, Samiron Phukan, Manojkumar Shukla, Lakshmi Narasimham, Kumar V.S. Nemmani, Mandar Bhonde, Sharad Sharma, Rajender K. Kamboj, Venkata P. Palle
Publikováno v:
European Journal of Pharmacology. 927:175054
PI3Kδ plays a critical role in adaptive immune cell activation and function. Suppression of PI3Kδ has been shown to counter excessive triggering of immune responses which has led to delineating the role of this isoform in the pathophysiology of aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa76af2abcce55ae46c64c0a261b565
https://doi.org/10.1016/j.ejphar.2022.175054
https://doi.org/10.1016/j.ejphar.2022.175054
Autor:
Manojkumar R, Shukla, Sukanya, Patra, Mahip, Verma, Gayathri, Sadasivam, Nirmal, Jana, Sachin J, Mahangare, Prashant, Vidhate, Dipak, Lagad, Anand, Tarage, Murthy, Cheemala, Chaitanya, Kulkarni, Shankar, Bhagwat, Vinod D, Chaudhari, Majid, Sayyed, Vipul, Pachpute, Ramesh, Phadtare, Gopal, Gole, Samiron, Phukan, Brahmam, Sunkara, Charudatt, Samant, Manisha, Shingare, Aditya, Naik, Sneha, Trivedi, Ajit Kumar, Marisetti, Madhusudhan, Reddy, Milind, Gholve, Nilesh, Mahajan, Sudeep, Sabde, Vinod, Patil, Dipak, Modi, Maneesh, Mehta, Prashant, Nigade, Kaustubh, Tamane, Swati, Tota, Hemant, Goyal, Harish, Volam, Shashikant, Pawar, Prajakta, Ahirrao, Lal, Dinchhana, Sadanand, Mallurwar, Atul, Akarte, Anand, Bokare, Rupesh, Kanhere, Neetinkumar, Reddy, Sarita, Koul, Manoj, Dandekar, Minakshi, Singh, Peter R, Bernstein, Lakshmi, Narasimham, Mandar, Bhonde, Jayasagar, Gundu, Rajan, Goel, Sanjeev, Kulkarni, Sharad, Sharma, Rajender Kumar, Kamboj, Venkata P, Palle
Publikováno v:
Journal of medicinal chemistry. 63(23)
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9740bbdfcab4b764d76303bebfd167f6
https://pubmed.ncbi.nlm.nih.gov/33297683
https://pubmed.ncbi.nlm.nih.gov/33297683
Publikováno v:
Cell Transplantation, Vol 10 (2001)
We have shown previously that chitosan-polyvinyl pyrrolidone (PVP) hydrogels are blood compatible, islet compatible, and noncytotoxic to various cell types. Because of these potential applications of chitosan-PVP hydrogel, the present study was desig
Externí odkaz:
https://doaj.org/article/b7be83f7b873461fbe6c98273c87b3dd
Autor:
Albi Francis, Javed S. Shaikh, Tariq Bhat, Sanjay P. Kurhade, Nivrutti Kamble, Harish Volam, Sadanand Mallurwar, Pushpak Bora, Prashant B. Nigade, Mandar Bhonde, Hemant Goyal, Gagan Kukreja, Nishant R. Gupta, Nageswara Rao Irlapati, Prajakta Ahirrao, Bernstein Peter Robert, Rajesh B. Shankar, Kumar Ram Naik, Sneha Naidu, Gopal Gole, Yogesh Pawar, Apparao Bommakanti, Vinod Patil, Rajendra G. Powar, V.R. Praveen Kumar, Rakesh Kumar, Prabhakaran Kamalakannan, Anil K. Hajare, Neelima Sinha, Rajender Kumar Kamboj, Jayasagar Gundu, Sharad Sharma, Nilesh Khedkar, Arun R. Jagdale, Navnath P. Karche, Venkata P. Palle, Dipak Modi, Saif Wahid, Vamsi Pagdala, Kochumalayil Shaji George, Ganesh R. Jadhav, Gourhari Jana, Rohan Limaye, Baban Thube, Lakshmi Narasimham, Harshal Khanwalkar, Shashikant Pawar, Kumar V.S. Nemmani, Rajesh Gupta, Minakshi Singh, Ramesh Kale, Ajay R. Tilekar, Samiron Phukan, Dhananjay Bakhle, Pradipta Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115819
The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is described. Compounds of structure I have good biochemical and cellular potency but suffered from inferior PK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439561d9cd7678612504a2221cbc22
https://doi.org/10.1016/j.bmc.2020.115819
https://doi.org/10.1016/j.bmc.2020.115819
Publikováno v:
Psychopharmacology. 235(5)
5-HT6 receptors are mainly expressed in brain areas associated with learning and memory. Several studies have reported procognitive effects of both 5-HT6 agonist and antagonists. However, the exact mechanism 5-HT6 receptor modulation has not been pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69613e125d42a967a9753c98c55dceef
https://pubmed.ncbi.nlm.nih.gov/29502275
https://pubmed.ncbi.nlm.nih.gov/29502275