Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mandana T. Manzari"'
Autor:
Chen Chen, You Wu, Shih-Ting Wang, Naxhije Berisha, Mandana T. Manzari, Kristen Vogt, Oleg Gang, Daniel A. Heller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Drug nanoaggregates are particles that can deleteriously cause false positive results during drug screening efforts, but alternatively, they may be used to improve pharmacokinetics when developed for drug delivery purposes. The structural fe
Externí odkaz:
https://doaj.org/article/90ab67803e894c0eb3d8de4a95ffb4b0
Autor:
Mandana T. Manzari, Hiroto Kiguchi, Laurie Herviou, Mariana da Silva Ferreira, Daniel A. Heller, Katia Manova-Todorova, Anas Younes, Connor J Hagen, Elisa de Stanchina, Neeta Bala Tannan, Venkatraman E. Seshan
Publikováno v:
Blood
Cancer and normal cells use multiple antiapoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing but is also associated with increased systemic toxicity. Here, we demonstrate that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4972181b4069da8c1c5d58d129ca4f
https://doi.org/10.1182/blood.2020008017
https://doi.org/10.1182/blood.2020008017
Autor:
Daniel A. Heller, Maurizio Scaltriti, Hiroto Kiguchi, Mandana T. Manzari, Yosi Shamay, Neal Rosen
Publikováno v:
Nat Rev Mater
Progress in the field of precision medicine has changed the landscape of cancer therapy. Precision medicine is propelled by technologies that enable molecular profiling, genomic analysis and optimized drug design to tailor treatments for individual p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77861143d14e79d8bff26167057c0ef
https://doi.org/10.1038/s41578-020-00269-6
https://doi.org/10.1038/s41578-020-00269-6
Autor:
Rachel N. Skelton, Merve Cakir, Simone A. Costa, Suzanne E. Wardell, Mitchell Zhang, Kevin H. Lin, Ashutosh Chilkoti, Kris C. Wood, Mareva Fevre, Joseph J. Bellucci, Ryan S. Soderquist, Mandana T. Manzari, Grace R. Anderson, Xinghai Li, Chandler E. Moore
Publikováno v:
Science Advances
Precision medicine strategy enables rational design of small molecule/protein drug combinations to overcome intrinsic resistance.
Extrinsic pathway agonists have failed repeatedly in the clinic for three core reasons: Inefficient ligand-induced
Extrinsic pathway agonists have failed repeatedly in the clinic for three core reasons: Inefficient ligand-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5782b47b23287b5a0d483017cb2a7ae
http://europepmc.org/articles/PMC6726446
http://europepmc.org/articles/PMC6726446
Autor:
Daniel A. Heller, Matthew B. Greenblatt, Daniel Tylawsky, Jeffrey Gerwin, Na Li, Praveen Raju, Janki Shah, Hiro Kiguchi, Jake Vaynshteyn, Mandana T. Manzari, Yosi Shamay
Publikováno v:
Neuro-Oncology
OBJECTIVE The Sonic Hedgehog (SHH) medulloblastoma subgroup accounts for ~25% of all cases and has an intermediate prognosis. Current therapies result in devastating morbidities including intellectual disability and secondary malignancies. Although m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930b65c417ff51ec917b65101f5f0439
https://doi.org/10.1093/neuonc/noaa222.050
https://doi.org/10.1093/neuonc/noaa222.050
Autor:
Daniel A. Heller, Venkatraman E. Seshan, Mandana T. Manzari, Mariana Da Silva Ferreira, Neeta Bala Bala, Zahra Asgari, Connor J Hagen, Anas Younes, Elisa de Stanchina, Katia Manova-Todorova
Publikováno v:
Blood. 134:305-305
Cancer and normal cell utilize multiple members of the anti-apoptotic BCL2 proteins to protect them from cell death. Selective targeting of the BCL2 protein has a limited therapeutic value in the majority of cancer patients, including lymphoma, mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c50c64b545eda6b67ec22ef82d81d63
https://doi.org/10.1182/blood-2019-130571
https://doi.org/10.1182/blood-2019-130571
Autor:
Mandana T. Manzari, Elizabeth K. Rosalia, Tiffany F. Chen, Jamie B. Spangler, K. Dane Wittrup
Publikováno v:
PMC
Dysregulation of epidermal growth factor receptor (EGFR) is a hallmark of many epithelial cancers, rendering this receptor an attractive target for cancer therapy. Much effort has been focused on the development of EGFR-directed antibody-based therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf471de509906704a8918144ea50037
https://doi.org/10.1016/j.jmb.2012.06.014
https://doi.org/10.1016/j.jmb.2012.06.014
Publikováno v:
Cancer Research. 78:LB-274
Death Receptor 5 (DR5) is a key upregulated marker in colorectal cancer (CRC), overexpressed in over 90% of patients. There is a dire clinical need for drugs that can deliver targeted cell killing via this receptor. Over the past decade, various DR5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d97a96e8a41a6011806ba2bf1b4cb3c
https://doi.org/10.1158/1538-7445.am2018-lb-274
https://doi.org/10.1158/1538-7445.am2018-lb-274