Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Manda Saraswati"'
Autor:
Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler, Courtney L. Robertson
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide preve
Externí odkaz:
https://doaj.org/article/8737e067513c446e870ab1247fb918a1
Autor:
Nagat El-Demerdash, Tiffany Pan, Olivia Choi, Manda Saraswati, Raymond C. Koehler, Courtney L. Robertson, Alena Savonenko
Publikováno v:
Journal of neurotrauma.
Therapies are limited for pediatric traumatic brain injury (TBI), especially for the very young who can experience long term consequences to learning, memory, and social behavior. Animal models of pediatric TBI have yielded mechanistic insights, but
Autor:
Bohdan J. Soltys, Carleton J. C. Hsia, Courtney L. Robertson, Li Ma, Jun Wang, Raymond C. Koehler, Manda Saraswati, Soichiro Seno, Suyi Cao, Jan Simoni, Sharon Park
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-12 (2020)
BMC Neuroscience
BMC Neuroscience
Background Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methe
Autor:
Oliver Avaritt, Courtney L. Robertson, Debbie L. Flock, Lee J. Martin, Manda Saraswati, Frances J. Northington, Jing Fang, Raul Chavez-Valdez
Publikováno v:
Neuroscience. 406:202-211
Neonatal hypoxic ischemic (HI) brain injury causes lifelong neurologic disability. Therapeutic hypothermia (TH) is the only approved therapy that partially mitigates mortality and morbidity. Therapies specifically targeting HI-induced brain cell deat
Autor:
Manda Saraswati, Raymond C. Koehler, Lindsey Rasmussen, Courtney L. Robertson, Sujatha Kannan, Zhi Zhang
Publikováno v:
Journal of Neurotrauma. 36:74-86
Neuroinflammation after traumatic brain injury (TBI) contributes to widespread cell death and tissue loss. Here, we evaluated sequential inflammatory response in the brain, as well as inflammation-induced changes in brain tryptophan metabolism over t
Autor:
Brandon Klein, Manda Saraswati, Zhi Zhang, Courtney L. Robertson, Sujatha Kannan, Megan O'Bryan, Samiha Ishrat
Publikováno v:
Journal of neurotrauma. 37(14)
Young children who have sustained severe traumatic brain injury (TBI) can suffer from debilitating neurocognitive deficits. Impairment of adult hippocampal neurogenesis is associated with cognitive deficits and depression. Very few studies have inves
Autor:
Carleton J. C. Hsia, Jan Simoni, Bohdan J. Soltys, Li Ma, Suyi Cao, Courtney L. Robertson, Jun Wang, Manda Saraswati, Sharon Park, Raymond C. Koehler, C. Danielle Hopkins, Soichiro Seno
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Journal of Neurotrauma. 32:1369-1379
Traumatic brain injury (TBI) is a common cause of disability in childhood, resulting in numerous physical, behavioral, and cognitive sequelae, which can influence development through the lifespan. The mechanisms by which TBI influences normal develop
Autor:
Manda Saraswati, Courtney L. Robertson
Publikováno v:
Journal of Bioenergetics and Biomembranes. 47:43-51
Progesterone has been studied extensively in preclinical models of adult traumatic brain injury (TBI), and has advanced to clinical trials in adults with TBI. However, there are very few preclinical studies in pediatric TBI models investigating proge
Autor:
Mary C. McKenna, Courtney L. Robertson, Paula Casey, Susanna Scafidi, Gary Fiskum, Manda Saraswati
Publikováno v:
Journal of Neurotrauma. 30:2066-2072
Altered cerebral metabolism and mitochondrial function have been identified in experimental and clinical studies of pediatric traumatic brain injury (TBI). Metabolic changes detected using (1)H (proton) magnetic resonance spectroscopy correlate with