Výsledky vyhledávání - "Manda J. Welsh"

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

Autor: Manda J. Welsh, Stephen G. Grant, Raghavan Balachandran, Billy W. Day

Publikováno v: The Prostate. 45:277-288

BACKGROUND. Z-1,1-Dichloro-2,3-diphenylcyclopropane (AII) has long been known to be active against models of breast carcinoma. Microtubule perturbation and interaction at type II estrogen binding sites mediate its actions. METHODS. Since these target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d676a64e3e1bdccf048b655703b45e4
https://doi.org/10.1002/1097-0045(20001201)45:4<277::aid-pros1>3.0.co

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Induction of human breast cancer cell apoptosis from G2/M preceded by stimulation into the cell cycle by Z-1,1-dichloro-2,3-diphenylcyclopropane

Autor: Stephen G. Grant, Raghavan Balachandran, Ernst ter Haar, Billy W. Day, Jack C. Yalowich, Manda J. Welsh

Publikováno v: Biochemical Pharmacology. 57:97-110

We have shown previously that Z-1,1-dichloro-2,3-diphenylcyclopropane (a.k.a. Analog II, A(II)) inhibits human breast cancer cell proliferation regardless of estrogen receptor status or estrogen sensitivity, and that its cellular targets include micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233bcbec66979559ac45e807cdbf2b92
https://doi.org/10.1016/s0006-2952(98)00289-5

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Increased Sensitivity of the Antiestrogen-Resistant MCF-7/LY2 Human Breast Carcinoma Cell Line to Apoptosis Induced by the Novel Microtubule Stabilizing Agent (+)-Discodermolide

Autor: Billy W. Day, Stephen G. Grant, Manda J. Welsh, Raghavan Balachandran

Publikováno v: The Breast Journal. 4:409-419

(+)-Discodermolide is a sponge-derived natural product with the most potent microtubule stabilizing activity yet discovered. Its actions parallel that of the promising antibreast cancer agent paclitaxel despite the lack of any apparent similarities i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27876667c92517b22a3b3fc1a37a3723
https://doi.org/10.1046/j.1524-4741.1998.460409.x

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The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxel

Autor: E ter Haar, Raghavan Balachandran, Stephen G. Grant, Manda J. Welsh, Billy W. Day

Publikováno v: Anti-Cancer Drugs. 9:67-76

(+)-Discodermolide, a sponge-derived natural product, stabilizes microtubules more potently than paclitaxel despite the lack of any obvious structural similarities between the drugs. It competitively inhibits the binding of paclitaxel to tubulin poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0fb663f11493b074722e925e87991e
https://doi.org/10.1097/00001813-199801000-00008

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Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility

Publikováno v: Clinical chemistry. 51(1)

Background: Protein expression profiling for differences indicative of early cancer has promise for improving diagnostics. This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3332be6bc662f8492204d6170673b4b1
https://pubmed.ncbi.nlm.nih.gov/15613702

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Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells

Autor: Raghavan Balachandran, Manda J. Welsh, Billy W. Day

Publikováno v: Oncogene. 22(55)

Two paclitaxel(Ptx)-resistant ovarian cancer cell lines, 1A9/Ptx-10 and 1A9/Ptx-22, isolated from the 1A9 cell line (a clone of the A2780 line) by continuous exposure to Ptx and verapamil, have point mutations in their major beta-tubulin gene and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636fee684cc5b279bf93e5c4acc10e79
https://pubmed.ncbi.nlm.nih.gov/14654788

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[Untitled]

Autor: Abbe N. Vallejo, Tomoyuki Imagawa, Manda J. Welsh, Norihiro Nishomoto, Takako Miyamae, Shumpei Yokota, William L. Bigbee, Raphael Hirsch, Bonnie Lemster, Masaaki Mori, David E. Malehorn, Klaus Klarskov

Publikováno v: Arthritis Research & Therapy. 7:R746

Systemic-onset juvenile idiopathic arthritis (SJIA) is a disease of unknown etiology with an unpredictable response to treatment. We examined two groups of patients to determine whether there are serum protein profiles reflective of active disease an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391bca95c3a1f86fd7b5fa56823d28b6
https://doi.org/10.1186/ar1723

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