Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas

Autor: Capdevila, J, Arques, O, Mora, JRH, Matito, J, Caratu, G, Mancuso, FM, Landolfi, S, Barriuso, J, Jimenez-Fonseca, P, Lopez, CL, Garcia-Carbonero, R, Hernando, J, Matos, I, Paolo, N, Hernandez-Losa, J, Esteller, M, Martinez-Cardus, A, Tabernero, J, Vivancos, A, Palmer, HG

Publikováno v: Clinical Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Purpose: The limited knowledge of the molecular alterations that characterize poorly differentiated neuroendocrine carcinomas has limited the clinical development of targeted agents directed to driver mutations. Here we aim to identify new molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::21b91f35b909391c7cf8d074a0c8eb79
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1223

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Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS‐mutant metastatic colorectal cancer

Autor: [Elez E, Sanz-García E, Noguerido A, Martini G, Macarulla T, Argilés G, Capdevila J, Garcia A, Tabernero J] Servei d’Oncologia Mèdica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. [Chianese C, Mancuso FM, Caratù G, Matito J, Vivancos A] Grup de Genòmica del Càncer, Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. [Martinelli E] Medical Oncology, Department of Clinical and Experimental Medicine ‘F. Magrassi’, Università della Campania ‘L. Vanvitelli’, Napoli, Italy. [Grasselli J] Servei d’Oncologia Mèdica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Servei d’Oncologia Mèdica, Institut Català d’Oncologia, L'Hospitalet, Spain. Universitat de Barcelona, L'Hospitalet, Spain. [Mulet N] Servei d’Oncologia Mèdica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Servei d’Oncologia Mèdica, Institut Català d’Oncologia, L'Hospitalet, Spain. Universitat de Barcelona, L'Hospitalet, Spain., Hospital Universitari Vall d'Hebron

Publikováno v: Scientia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______272::4be30f95cd2b0f5cc616e069145c83c3
https://hdl.handle.net/2072/433702

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer

Autor: Frigola Rissech, Joan, Navarro, Alejandro, Carbonell, Caterina, Callejo, Anna, Iranzo, Patricia, Cedrés, Susana, Martinez-Marti, Alex, Pardo Aranda, Nuria, Saoudi-Gonzalez, Nadia, Martinez, Débora, Jiménez, José, Sansano, Irene, Mancuso, Francesco M., Nuciforo, Paolo, Montuenga, Luis M., Sanchez-Cespedes, Montse, Prat, Aleix, Vivancos, Ana, Felip, Enriqueta, Amat, Ramón, Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Oncology
Scientia
Molecular Oncology, Vol 15, Iss 4, Pp 887-900 (2021)

We molecularly characterized tumors from non‐small cell lung cancer patients, focusing on long‐term responders to immune checkpoint inhibitors and showed that these patients present high tumor mutation burden and low somatic copy number alteratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b2cfd90e6845eed8b6bb232784e4b7
https://ddd.uab.cat/record/236714

Not All Genes Are Equal; Shortage of Histones Affects Some Genes More Than Others

Autor: Massimiliano Pagani, Francesco M. Mancuso, Assaf Weiner, Alessandra Agresti, Nir Friedman, Barbara Celona, Riccardo L. Rossi, Elisa Cesarini, Jiannis Ragoussis, Grazisa Rossetti, Marco Bianchi, Francesca Di Felice, Tiziana Bonaldi, Lorna Gregory, Giorgio Camilloni, Paolo Grianti, Dilair Baban

Publikováno v: PLoS Biology
PLoS biology (2011).
info:cnr-pdr/source/autori:Celona B, Weiner A, Di Felice F, Mancuso FM, Cesarini E, Rossi RL, Gregory L, Baban D, Rossetti G, Grianti P, Pagani M, Bonaldi T, Ragoussis J, Friedman N, Camilloni G, Bianchi ME, Agresti A/titolo:Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output/doi:/rivista:PLoS biology/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume
PLoS Biology, Vol 9, Iss 6, p e1001086 (2011)
PLoS Biology; Vol 9

The basic unit of genome packaging is the nucleosome, and nucleosomes have long been proposed to restrict DNA accessibility both to damage and to transcription. Nucleosome number in cells was considered fixed, but recently aging yeast and mammalian c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73810bfa18386cdeeada5adca20ebe56
http://europepmc.org/articles/PMC3125158