Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes

Autor: Iyer Aditya Mahadevan, Sanjeev Kumar, Manchanahalli R. Satyanarayana Rao

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-19 (2020)

Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. O

Externí odkaz: https://doaj.org/article/c699e373b4354077b7b1846b97c83761

Analysis of cellular models of clonal evolution reveals co-evolution of imatinib and HSP90 inhibitor resistances

Autor: Meher B. Gayatri, Dashavantha Reddy Vudem, Manchanahalli R. Satyanarayana Rao, Shweta Malladi, Preethi Pattamshetty, Rajender Goud Arolla, Aramati B. M. Reddy, Utsa Bhaduri, Madhumohan R. Katika, Rama Krishna Kancha, Vasavi Mohan

Publikováno v: Biochemical and Biophysical Research Communications. 534:461-467

Treatment relapse due to clonal evolution was shown to be an independent factor for poor prognosis in advanced stages of chronic myeloid leukemia. Overcoming secondary resistance arising due to clonal evolution is still an unmet need and lack of adeq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ac0f6cfbd69b884a1f368f9dd7fd22
https://doi.org/10.1016/j.bbrc.2020.11.059

AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells

Autor: Prathima B. Nagendra, Manchanahalli R. Satyanarayana Rao, Arun Renganathan, Vasudeva Bhat, Brian Steve Mathew, Swati Sinha

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports

Glioblastoma (GBM) is the most common aggressive form of brain cancer with overall dismal prognosis (10–12 months) despite all current multimodal treatments. Previously we identified adipocyte enhancer binding protein 1 (AEBP1) as a differentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7520ccf37e1601c5726515e376127f
http://link.springer.com/article/10.1038/s41598-019-51068-1

LncRNA Hmrhl regulates expression of cancer related genes in Chronic Myelogenous Leukemia through chromatin association

Autor: Sangeeta Dutta, Utsa Bhaduri, Manchanahalli R. Satyanarayana Rao, Subhendu Roy Choudhury

Publikováno v: NAR Cancer

Long non-coding RNA has emerged as a key regulator of myriad gene functions. One such lncRNA mrhl, reported by our group, was found to have important role in spermatogenesis and embryonic development in mouse. Recently, its human homolog, Hmrhl was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b734db4a11505b5df078a60022bee0
https://doi.org/10.1101/2020.09.17.301770

TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes

Autor: Satyakrishna Pentakota, Manchanahalli R. Satyanarayana Rao, Raktim Roy, Iyer Aditya Mahadevan, Utsa Bhaduri

Publikováno v: Epigenetics & Chromatin
Mahadevan, I A, Pentakota, S, Roy, R, Bhaduri, U & Satyanarayana Rao, M R 2019, ' TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes ', Epigenetics & Chromatin, vol. 12, no. 1, 53 . https://doi.org/10.1186/s13072-019-0300-y
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-23 (2019)

BACKGROUND: TH2B is a major histone variant that replaces about 80-85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermatocytes and spermatids. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bf5bdb500c75bc2513b6d5d220d430
http://europepmc.org/articles/PMC6731575