Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes

Autor: Iyer Aditya Mahadevan, Sanjeev Kumar, Manchanahalli R. Satyanarayana Rao

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-19 (2020)

Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. O

Externí odkaz: https://doaj.org/article/c699e373b4354077b7b1846b97c83761

Analysis of cellular models of clonal evolution reveals co-evolution of imatinib and HSP90 inhibitor resistances

Autor: Meher B. Gayatri, Dashavantha Reddy Vudem, Manchanahalli R. Satyanarayana Rao, Shweta Malladi, Preethi Pattamshetty, Rajender Goud Arolla, Aramati B. M. Reddy, Utsa Bhaduri, Madhumohan R. Katika, Rama Krishna Kancha, Vasavi Mohan

Publikováno v: Biochemical and Biophysical Research Communications. 534:461-467

Treatment relapse due to clonal evolution was shown to be an independent factor for poor prognosis in advanced stages of chronic myeloid leukemia. Overcoming secondary resistance arising due to clonal evolution is still an unmet need and lack of adeq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ac0f6cfbd69b884a1f368f9dd7fd22
https://doi.org/10.1016/j.bbrc.2020.11.059

A novel enhancer RNA, Hmrhl, positively regulates its host gene, phkb, in chronic myelogenous leukemia

Autor: Subhendu Roy Choudhury, Divya T Rajendran, Utsa Bhaduri, Roshan Fatima, Manchanahalli R. Satyanarayana Rao

Publikováno v: Non-coding RNA Research, Vol 4, Iss 3, Pp 96-108 (2019)

Noncoding RNAs are increasingly being accredited with key roles in gene regulation during development and disease. Here we report the discovery and characterization of a novel long noncoding RNA, Hmrhl, which shares synteny and partial sequence simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1aa56490f1b201a4807f8e58ae5b950
https://doi.org/10.1016/j.ncrna.2019.08.001

LncRNA Hmrhl regulates expression of cancer related genes in Chronic Myelogenous Leukemia through chromatin association

Autor: Sangeeta Dutta, Utsa Bhaduri, Manchanahalli R. Satyanarayana Rao, Subhendu Roy Choudhury

Publikováno v: NAR Cancer

Long non-coding RNA has emerged as a key regulator of myriad gene functions. One such lncRNA mrhl, reported by our group, was found to have important role in spermatogenesis and embryonic development in mouse. Recently, its human homolog, Hmrhl was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b734db4a11505b5df078a60022bee0
https://doi.org/10.1101/2020.09.17.301770

TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes

Autor: Satyakrishna Pentakota, Manchanahalli R. Satyanarayana Rao, Raktim Roy, Iyer Aditya Mahadevan, Utsa Bhaduri

Publikováno v: Epigenetics & Chromatin
Mahadevan, I A, Pentakota, S, Roy, R, Bhaduri, U & Satyanarayana Rao, M R 2019, ' TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes ', Epigenetics & Chromatin, vol. 12, no. 1, 53 . https://doi.org/10.1186/s13072-019-0300-y
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-23 (2019)

BACKGROUND: TH2B is a major histone variant that replaces about 80-85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermatocytes and spermatids. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bf5bdb500c75bc2513b6d5d220d430
http://europepmc.org/articles/PMC6731575