Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Manbir Sandhu"'
Autor:
Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H. Lee, David E. Gloriam, Stéphane A. Laporte, M. Madan Babu, Nagarajan Vaidehi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
G protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein i
Externí odkaz:
https://doaj.org/article/3f58c0dca0e94af083460b63eb5f6506
Autor:
Manbir Sandhu, Shawn Hurley, Lorena Ruiz, Jacqueline Imbert-Mummery, Shoko Nitta, Charles S. Stout, J. Diego Lozano
Publikováno v:
Interdisciplinary Neurosurgery, Vol 31, Iss , Pp 101682- (2023)
Background: Cerebral vein/sinus thrombosis (CVST) is an uncommon cause of stroke. In addition, the varied clinical syndromes present in adults with CVST pose diagnostic challenges. Nonetheless, the rise of CT and MRI as well as the increased awarenes
Externí odkaz:
https://doaj.org/article/1e05c53518314475b9bca4cad0134c01
Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Autor:
Avisek Majumder, Manbir Sandhu, Debarko Banerji, Veronica Steri, Adam Olshen, Mark M. Moasser
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HER2 and HER3 play key driving functions in the pathophysiology of HER2-amplified breast cancers, but this function is less well characterized in other cancers driven by HER2 amplification. This study aimed to explore the role of HER2 and HE
Externí odkaz:
https://doaj.org/article/c397830c5fdc4bd9aad3949e664aac3c
Autor:
Ragini Bhargava, Manbir Sandhu, Sanychen Muk, Gabriella Lee, Nagarajan Vaidehi, Jeremy M. Stark
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tool
Externí odkaz:
https://doaj.org/article/850cf4aec291433da8ab79aea3811444
Autor:
Siquan Chen, Asif Zubair, Ravi C. Kalathur, M. Madan Babu, Jon P. Connelly, Darcie J. Miller, Kaley Blankenship, Min Pan, Michael A. Dyer, Jake E. Batchelder, Shondra M. Pruett-Miller, Brandt C. Huddle, Matthew J. Posgai, Scott C. Blanchard, William C. Wright, Richard H. Chapple, Samuel W. Brady, Sivaraman Natarajan, Payton Archer, John Easton, Elizabeth Stewart, Paul Geeleher, Jonathan Low, Lucy A. Godley, John D. Schuetz, Taosheng Chen, Manbir Sandhu, Burgess B. Freeman, Yingzhe Wang, Brittney Gordon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal impact. Here, we identify the small molecule CX-5461 as selectively cytotoxic to high-risk neu
Autor:
Qingwen Wan, Manbir Sandhu, Najeah Okashah, Nagarajan Vaidehi, Soumadwip Ghosh, Nevin A. Lambert, Asuka Inoue
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance G protein-coupled receptors (GPCRs) regulate a wide variety of important cellular processes and are targeted by a large fraction of approved drugs. GPCRs signal by activating heterotrimeric G proteins and must couple to a select subset o
Publikováno v:
International Journal of Scientific Research in Science, Engineering and Technology. :210-214
Big data is a fast-growing technology that has the scope to mine huge amount of data to be used in various analytic applications. With large amount of data streaming in from a myriad of sources: social media, online transactions and ubiquity of smart
Publikováno v:
Journal of Chemical Information and Modeling. 57:3011-3021
Proliferating cell nuclear antigen (PCNA) is a member of the family of sliding clamp proteins that serves as a clamp during DNA repair, DNA replication, cell cycle control, and multiple forms of chromatin modification. PCNA functions as a homotrimer
Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα
Autor:
Sangbae Lee, Manbir Sandhu, Nagarajan Vaidehi, Adrien B. Larsen, Titu Devamani, Hyun Deok Song, Sivaraj Sivaramakrishnan, Ruth F. Sommese, Abhinandan Jain
Publikováno v:
Journal of Biological Chemistry. 292:16300-16309
Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple peptide substrates. Although the consensus sequence motif has been identified and used to explain substrate specificity for PKCα, it does not inform the stru