Výsledky vyhledávání - "Manasa P. Ravindra"

Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Autor: Adrianne Wallace-Povirk, Mohammad A. Karim, Juiwanna Kushner, Larry H. Matherly, Kathryn White, Manasa P. Ravindra, Carrie O'Connor, Nian Tong, Lisa Polin, Aleem Gangjee, Mike R. Wilson, Zhanjun Hou

Publikováno v: Journal of Medicinal Chemistry. 61:4228-4248

Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo[2,3- d]pyrimidine analogues 7-12 were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or the proton-coupled folate transporter (PCFT) and for antitumor eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fc965f19b043529dc50f7e75b2092e
https://doi.org/10.1021/acs.jmedchem.8b00408

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Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis

Autor: Aleem Gangjee, Christina George, Juiwanna Kushner, Adrianne Wallace-Povirk, Carrie O'Connor, Lisa Polin, Mike R. Wilson, Zhanjun Hou, Manasa P. Ravindra, Mohammad A. Karim, Kathryn White, Larry H. Matherly

Publikováno v: Journal of Medicinal Chemistry. 61:2027-2040

Tumor-targeted specificities of 6-substituted pyrrolo-[2,3-d]pyrimidine analogues of 1, where the phenyl side-chain is replaced by 3′,6′ (5, 8), 2′,5′ (6, 9), and 2′,6′ (7, 10) pyridyls, were analyzed. Proliferation inhibition of isogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8aa7145e296abb3cf3ad16cbd64f57
https://doi.org/10.1021/acs.jmedchem.7b01708

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Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation

Autor: Suravi Chakrabarty, Manasa P. Ravindra, Rishabh Mohan, Arpit Doshi, Fraser F. Fleming, Fa-Qiang Liu, Shruti Choudhary, Xun Yang, Dhruv Shah

Publikováno v: Advanced Synthesis & Catalysis. 356:2135-2196

Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex nitrogenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9815de2955937adefa09ad822414ad66
https://doi.org/10.1002/adsc.201400017

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Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Autor: Aleem Gangjee, Manasa P. Ravindra, Shermaine Mitchell-Ryan, Larry H. Matherly, Steven Orr, Eric C. Hales, Sudhir Raghavan, Christina Cherian, Zhanjun Hou, Yiqiang Wang

Publikováno v: Journal of Medicinal Chemistry. 56:10016-10032

We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04814daf7076b8793492dfa4f0b9b0fe
https://doi.org/10.1021/jm401328u

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Abstract 3239: Selective tumor targeting with 5-substituted pyrrolo[2,3-d]pyrimidines with heteroatom bridge substitution

Autor: Adrianne Wallace-Povirk, Manasa P. Ravindra, Larry H. Matherly, Aleem Gangjee, Aamod Dekhne, Rishabh Mohan, Zhanjun Hou, Carrie O'Connor

Publikováno v: Cancer Research. 77:3239-3239

Three specialized systems exist for membrane transport of folates and antifolates across biological membranes. The reduced folate carrier (RFC) is ubiquitously expressed in tumors and normal tissues. Folate receptors (FR) α and β, and the proton-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::695359ca5f604b53161d9fd174d95af6
https://doi.org/10.1158/1538-7445.am2017-3239

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ChemInform Abstract: Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation

Autor: Rishabh Mohan, Manasa P. Ravindra, Arpit Doshi, Xun Yang, Fa-Qiang Liu, Suravi Chakrabarty, Dhruv Shah, Fraser F. Fleming, Shruti Choudhary

Publikováno v: ChemInform. 45

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca5452e67a258d4e7f306a05f3fc1d1a
https://doi.org/10.1002/chin.201437256

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Abstract 1359: Design, synthesis and evaluation of fluorinated antifolates for improved selectivity and potency against tumor cells

Autor: Manasa P. Ravindra, Larry H. Matherly, Aleem Gangjee, Lisa P. Hou, Adrianne Wallace Povrik, Mike R. Wilson, Zhanjun Hou, Carrie O'Connor

Publikováno v: Cancer Research. 76:1359-1359

Folates are important single carbon transferring cofactors required for the biosynthesis of purine and pyrimidine nitrogen bases and DNA. Antifolates inhibit synthesis of these nitrogenous bases and function as antineopastic agents. The use of curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32fb4116558e6c87174bed4e901a7f31
https://doi.org/10.1158/1538-7445.am2016-1359

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Abstract 3824: Design, synthesis and biological evaluation of 4-atom side chain pemetrexed (PMX) homolog AG127 as a potent inhibitor of tumors expressing folate receptors via 5-aminoimidazole-4-carboxamide ribonucleotide formyl transferase (AICARFTase) inhibition

Autor: Roy L. Kisliuk, Larry H. Matherly, Aleem Gangjee, Manasa P. Ravindra, Shermaine Mitchell Ryan, Yiqiang Wang

Publikováno v: Cancer Research. 72:3824-3824

Two major hurdles in cancer therapy are the inability of chemotherapeutic agents to selectively target tumor cells over normal tissues, and the development of tumor cell resistance. The multi-enzyme-targeted anticancer drug pemetrexed (PMX) suffers f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4c5f0f2f1777d4a04918c6788344428
https://doi.org/10.1158/1538-7445.am2012-3824

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