Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Manasa K Nayak"'
Autor:
Jakub M Kwiecinski, Heidi A Crosby, Claire Valotteau, Joseph A Hippensteel, Manasa K Nayak, Anil K Chauhan, Eric P Schmidt, Yves F Dufrêne, Alexander R Horswill
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007800 (2019)
Staphylococcus aureus is a leading cause of endovascular infections. This bacterial pathogen uses a diverse array of surface adhesins to clump in blood and adhere to vessel walls, leading to endothelial damage, development of intravascular vegetation
Externí odkaz:
https://doaj.org/article/a054eb9fbd2c4c719f03495349f5698f
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105049 (2014)
Aspirin is widely used in clinical settings as an anti-inflammatory and anti-platelet drug due its inhibitory effect on cyclooxygenase activity. Although the drug has long been considered to be an effective and safe therapeutic regime against inflamm
Externí odkaz:
https://doaj.org/article/c6ee655b6aed4724a4b5d45ed92bf529
Autor:
Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan
Publikováno v:
Blood Advances. 7:2347-2359
Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In contrast, platelet activation exhibits an increased rate of aerobic gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620a87871158a4625fb82640a7b1cd29
https://doi.org/10.1182/bloodadvances.2023010100
https://doi.org/10.1182/bloodadvances.2023010100
Autor:
Manasa K. Nayak, Nirav Dhanesha, Prakash Doddapattar, Omar Rodriguez, Vijay K. Sonkar, Sanjana Dayal, Anil K. Chauhan
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 2029-2038 (2018)
Abstract: Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) to generate adenosine triphosphate, whereas activated platelets exhibit a high level of aerobic
Externí odkaz:
https://doaj.org/article/0dc783ca8a2c4854901e37d2f8243550
Autor:
Madankumar Ghatge, Manasa K. Nayak, Gagan D. Flora, Mariia Kumskova, Aditi Jain, Rakesh B. Patel, Zhihong Lin, Yuriy M. Usachev, Anil K. Chauhan
Publikováno v:
Journal of Thrombosis and Haemostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::174aad4892db75908458441334f0c4d6
https://doi.org/10.1016/j.jtha.2023.04.002
https://doi.org/10.1016/j.jtha.2023.04.002
Autor:
Anil K. Chauhan, Steven R. Lentz, Manasa K. Nayak, Manish Jain, Prakash Doddapattar, Liang Guo, Anne Cornelissen, Nirav Dhanesha, Aloke V. Finn
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41:1724-1737
Objective: The role of glycolytic enzyme PKM2 (pyruvate kinase muscle 2) in smooth muscle cell (SMC) phenotype switching and neointimal hyperplasia is poorly understood. We determined the role of PKM2 in SMC phenotype switching and neointimal hyperpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc44984babce518c7cfea3be32c0c17
https://doi.org/10.1161/atvbaha.121.316021
https://doi.org/10.1161/atvbaha.121.316021
Autor:
Nirav Dhanesha, Madankumar Ghatge, Manasa K. Nayak, Steven R. Lentz, Gagan D. Flora, Matthew J. Potthoff, Kathleen R. Markan, Anil K. Chauhan, Manish Jain
Publikováno v:
Blood
Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ac31c11b1b31d3b0df4861e454c06
https://doi.org/10.1182/blood.2020007140
https://doi.org/10.1182/blood.2020007140
Autor:
Shigeyuki Kon, Madankumar Ghatge, Steven R. Lentz, Girish Bathla, Prakash Doddapattar, Amit Kumar Tripathi, Mehul R. Chorawala, Manasa K. Nayak, Nirav Dhanesha, Anil K. Chauhan, Manish Jain
Publikováno v:
Circ Res
Rationale: Currently, there is no effective intervention available that can reduce brain damage following reperfusion. Clinical studies suggest a positive correlation between the increased influx of neutrophils and severity of brain injury following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53fbbc5040a47d3850eea9806133490
https://doi.org/10.1161/circresaha.120.316659
https://doi.org/10.1161/circresaha.120.316659
Autor:
Daniel R. Thedens, Nirav Dhanesha, Manish Jain, Prakash Doddapattar, Manasa K. Nayak, Anil K. Chauhan, Mehul R. Chorawala, Abhinav Bhalla
Publikováno v:
Stroke. 50:1201-1209
Background and Purpose— Cellular Fn-EDA (fibronectin containing extra domain A) is expressed in activated endothelial cells and elevated in circulation in patients with cardiovascular diseases. Although global deficiency of Fn-EDA in mice improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e111b63d0a47d6c7a0bfaf27e31166c
https://doi.org/10.1161/strokeaha.118.023697
https://doi.org/10.1161/strokeaha.118.023697
Autor:
Massimo Attanasio, Anil K. Chauhan, Heng Jin, Biswajit Padhy, Dao-Fu Dai, Qiong Ding, Madison Purvis, Chou Long Huang, Chang Shu, Can Li, Manasa K. Nayak, Dingxiao Liu
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight, Vol 6, Iss 9 (2021)
Loss of function of the lipid kinase diacylglycerol kinase ε (DGKε), encoded by the gene DGKE, causes a form of atypical hemolytic uremic syndrome that is not related to abnormalities of the alternative pathway of the complement, by mechanisms that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597c045ce5dcf0de41d3067495f1f6b
https://doi.org/10.1172/jci.insight.146959
https://doi.org/10.1172/jci.insight.146959