Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Manana Melikishvili"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Poly (ADP)-ribose polymerase 1 (PARP1) is an abundant nuclear protein well-known for its role in DNA repair yet also participates in DNA replication, transcription, and co-transcriptional splicing, where DNA is undamaged. Thus, binding to un
Externí odkaz:
https://doaj.org/article/692a821642f84adf9a04f12dc4e72fb2
Autor:
Eun Suk Song, Manana Melikishvili, Michael G Fried, Maria A Juliano, Luiz Juliano, David W Rodgers, Louis B Hersh
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46790 (2012)
Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme w
Externí odkaz:
https://doaj.org/article/96dae104c9384c608ee2aae9d12520ab
Autor:
Manana Melikishvili, Michael Fried
Publikováno v:
Nucleic Acids Research
Human O6-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O6-alkylguanine and O4-alkylthymine adducts in single-stranded and duplex DNAs. The search for these lesions, through a vast excess of competing, unmodified genomic DNA, is a mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293c74f516d6915133da562b696acd5e
https://doi.org/10.1093/nar/gkx223
https://doi.org/10.1093/nar/gkx223
Publikováno v:
Cell Discovery
Recent studies implicate Poly (ADP-ribose) polymerase 1 (PARP1) in alternative splicing regulation, and PARP1 may be an RNA-binding protein. However, detailed knowledge of RNA targets and the RNA-binding region for PARP1 are unknown. Here we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed99f0355cd42bca2f3be1d67d4544c
https://doi.org/10.1038/celldisc.2017.43
https://doi.org/10.1038/celldisc.2017.43
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12dc4e4977b48cd4b133097a7d738f44
https://pubmed.ncbi.nlm.nih.gov/28695513
https://pubmed.ncbi.nlm.nih.gov/28695513
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1608
There is a long list of important RNA-binding proteins (RBP) involved in different steps of gene expression through posttranscriptional modifications: pre-mRNA splicing, mRNA stabilization, polyadenylation, mRNA export from nucleus to the cytoplasm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fb23bee6c436e68501de0f5db5fc0ce
https://pubmed.ncbi.nlm.nih.gov/28956326
https://pubmed.ncbi.nlm.nih.gov/28956326
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969920
There is a long list of important RNA-binding proteins (RBP) involved in different steps of gene expression through posttranscriptional modifications: pre-mRNA splicing, mRNA stabilization, polyadenylation, mRNA export from nucleus to the cytoplasm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04286931292011a74bcfd6c48192dfc
https://doi.org/10.1007/978-1-4939-6993-7_15
https://doi.org/10.1007/978-1-4939-6993-7_15
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49b5bccb27bf665ca0cec91853731d6
https://doi.org/10.1007/978-1-4939-6993-7_30
https://doi.org/10.1007/978-1-4939-6993-7_30
Publikováno v:
Nucleic Acids Research
O 6-alkylguanine-DNA alkyltransferase (AGT) is a single-cycle DNA repair enzyme that removes pro-mutagenic O6-alkylguanine adducts from DNA. Its functions with short single-stranded and duplex substrates have been characterized, but its ability to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491a1155bc5a21cf2e6800f2548a0352
https://doi.org/10.1093/nar/gku659
https://doi.org/10.1093/nar/gku659
Autor:
Manana Melikishvili, Michael Fried
Publikováno v:
Nucleic Acids Research. 40:9060-9072
Binding experiments with alkyl-transfer-active and -inactive mutants of human O6-alkylguanine DNA alkyltransferase (AGT) show that it forms an O6-methylguanine (6mG)-specific complex on duplex DNA that is distinct from non-specific assemblies previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b77fee5552a1f95cf975b079ee3cdd6
https://doi.org/10.1093/nar/gks674
https://doi.org/10.1093/nar/gks674