Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C

Autor: Mira Huyghe, Mitchell L. Shiffman, Paul J. Pockros, Eugene R. Schiff, Robert G. Gish, David Hecht, John G. McHutchison, David Shapiro, Manana Makhviladze, Tilman Oltersdorf, Nezam H. Afdhal

Publikováno v: Hepatology. 46:324-329

Increased rates of apoptosis (programmed cell death) have been demonstrated in many hepatic diseases including chronic hepatitis C. IDN-6556 is a potent inhibitor of caspases, the proteases that execute apoptosis. In a prior phase 1 study, IDN-6556 l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121404e35135b86767e5ecfb67f5c2e7
https://doi.org/10.1002/hep.21664

FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

Autor: Arkadiy L. Vertkin, Mihaela Flavia Grosan, Jorge Garbino, Irina V. Dvoryashina, Dirk Thye, Manana Makhviladze, Norbert Suttorp, Ivan Chopey, Dan Olteanu, Louis Van Zyl, Nadiya Tryshchuk, Rustem F. Khamitov, Ronel Meeding, Juan Oriz de Saracho, Lucia Cristina, Daniel Horacio Pryluka, Poj Intalapaporn, V Falcó, Noor Aliza bt Md Tarekh, Vitalija Nausediene, Fernando Gongora Rubio, Mashra Gani, Luis Carlos Losso, Sergio Edwardo Prieto, Klaus Dalhoff, Martti Jaanus, Evgeny A. Gamal, Pinyo Horsin, Tatjana Pejcic, Marco Pons, Zsuzsa Mark, Elmira Zilber, Lily Llorens, Jean-Pierre Bru, Nilton Brandao da Silva, Birute Alekniene, Paul B. Eckburg, Karl-Matthius Deppermann, Vasyl Neyko, Elida Carmen Pallone, Daniel Genne, Jussara Costa Fiterman, Bruno Mégarbane, Ingrid Engelbrecht, Renata Jankowska, Antoni Torres, Madeleine Rothen, Maria Puschita, Yuriy M. Ambalov, Rolf Henrich, Skaidrius Miliauskas, Anan Wattanathum, Anthony Ramage, Júlio César Abreu de Oliveira, George Kavtaradze, Revaz Tabukashvili, Abdul Manap, Danuta Pupek-Musialik, Anna G. Yevdokimova, Philip Giordano, Joseph De Santo, John Pullman, Pablo Bonvehí, Wolfgang Petermann, Emilio Bouza, Claudia Gavris, Paulo José Zimermann Teixeira, Carlos Ernesto Ferreira Starling, Vsevolod Roudas, James Welker, Maria Cristina Ganaha, Ewa Ziolko, Czeslaw Marcisz, Christian Jakobeit, Juliani Souza Lima, Antonio Tarcisio de Faria Freire, Claudia Gabriela Rodiguez, Eva Francovszky, Andrej Dukat, Christian Grohe, Pawe Piotrowicz, Volodymyr Yefimov, Dwight D. Eisenhower, Clovis Arns da Cunha, Charoen Churchottaworn, Dusica Celeketic, Benoit Misset, Andrzej Rydzewski, Jan Alan Winetz, William Tillis, Zoltán Balikó, Roman Dutka, Mihaela Lupse, H. David Friedland, Evelina Troshanova, Krzysztof Czarnobilski, Maria Auxiliadora Carmo Moreira, Zorica Lazic, Halina Batura-Gabryel, Selcuk Tasci, Márta Bisits, Sulev Meriste, Paul Manos, Gustavo Lopardo, Ana Leticia Gurini, Wolfgang Auch-Schwelk, Gabriela Jimborean, Coenie Koegelenberg, Maciej Hamankiewicz, Roslina Binte, Ian A. Critchley, Thomas M. File, Marija Mitic-Milikic, Yuriy Kolchyn, Thanomsak Anekthananon, Jean Pierre Sollet, Tetiana Tetiana Pertseva, Mari Dzhabalyan, Kai Sukles, Datin Hjh Aziah Ahmad Mahayiddin, Jan Plutinsky, Gyorgy Losonczy, Malgorzata Gutowska-Jablonska, Arvydas Valavicius, Johannes Breedt, Ewa Trebas-Pietras, Alberto Capelastegui, Christian Schrock, Jan Dulawa, Joachim Zerbst, Andreas Fertl, J. Mario Gonzalez, Ishmail Mitha, Donald E. Low, Matthys Basson, Gernot Rohde, Jon Lee, Joachim Lorenz, Istvan Albert, Voicu Mircea Tudorache, Chaicharn Pothirat, Victoria Arama Senior, Marian Wendland, Ricardo Augusto Teijeiro, Conrado Shum, Vasyl Melnyk, Jean-Michel Molina, Abdul Pazak Bin Abdul Muttalif, Olga V. Reshetko, Johannes Roos, Muhammed Fulat, Igor Leschenko, Igor Kaydashev, Mila Petkova, Anna N. Galustyan, Volodymyr Havrysyuk, Jan Kus, Lyudmyla Yashyna, Oleksandr Smolyanyi, George H. Talbot, Vladimir A. Rudnov, Stanislovas Naudziunas, Purvi Mehra, Kiew Kuang Kiat, Victoria Rodionova, Karoly Fonay, Ireneusz Tyszkiewic, Vania Youroukova, Marius Le Roux, Johannes Bonelli, Rosario Menéndez, Maria Patelli, Nikola Milinic, Gheorgita Aron, Krzysztof Janik, Bhaskar Venkateswaralu, Piroon Mootsikapun, Nadiya Monogarova, Ginataras Kramilius, Christian Schumann, Eliza Baranska, Jaco Jurgens

Publikováno v: The Journal of antimicrobial chemotherapy. 66

Objectives Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2eb7e0fd2a5a7db89a9008e6fc58e3
https://pubmed.ncbi.nlm.nih.gov/21482566