Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Manana Kandashvili"'
1
Memantine treatment prevents okadaic acid induced neurotoxicity at the systemic and molecular levels
Autor: Gela V Beselia, Mariam R. Chighladze, Lali B. Kruashvili, Revaz Solomonia, Nino C Chkhikvishvili, Manana Kandashvili, Manana G Dashniani, Maia A Burjanadze
Publikováno v: NeuroReport. 31:281-286
The present study was designed to investigate the effects of okadaic acid intracerebroventricular (ICV) injection on memory function and expression level of α7 subunit of nicotinic acetylcholine receptor (nAChR) and NR2B subunit of NMDA glutamate re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ae3dad6021eebb04a90a27b6eb3e1b
https://doi.org/10.1097/wnr.0000000000001375
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2
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats
Autor: Manana Kandashvili, Georgi Gamkrelidze, Lia Tsverava, Tamar Lordkipanidze, Eka Lepsveridze, Vincenzo Lagani, Maia Burjanadze, Manana Dashniani, Merab Kokaia, Revaz Solomonia
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1198, p 1198 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1198
Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60c6e5849b8e81d6974d0abb0ef2cb
https://www.mdpi.com/1422-0067/23/3/1198
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3
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis
Autor: Lia Tsverava, Eka Lepsveridze, Giorgi Margvelani, Merab Kokaia, Manana Kandashvili, Tamar Lortkipanidze, Georgi N. Gamkrelidze, Revaz Solomonia
Publikováno v: BioMed Research International
BioMed Research International, Vol 2019 (2019)
Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by numerous functional and structural pathophysiological reorganizati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74da6fc58a1579d35508bb26abfc706
https://doi.org/10.1155/2019/4518160
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4
Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons
Autor: Maia A Burjanadze, Revaz Solomonia, Manana Kandashvili, Manana G Dashniani, Temur L. Naneishvili, Mariam R. Chighladze, Nino C Chkhikvishvili, Gela V Beselia, Lali B. Kruashvili
Publikováno v: Experimental brain research. 238(10)
The medial septum (MS) is an important modulator of hippocampal function. The degree of damage in which the particular set of septo-hippocampal projections contributes to the deficits of spatial memory with concomitant changes of hippocampal receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a044d2117c9b8a08a5d857ae38747c4
https://pubmed.ncbi.nlm.nih.gov/32770352
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5
Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo
Autor: Merab Kokaia, Zaqaria I. Nanobashvili, Revaz Solomonia, Irina G. Bilanishvili, Tamar Lordkipanidze, Manana Kandashvili, Georgi N. Gamkrelidze
Publikováno v: Neuroreport. 30(16)
Epilepsy is one of the most widespread neurological diseases characterized by spontaneous recurrent seizures. There is no cure for epilepsy, and available pharmacological treatments with anti-seizure drugs are only symptomatic. Moreover, about third
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e645a61e7196d7ae93e8ad26e6205fb
https://pubmed.ncbi.nlm.nih.gov/31568207
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6
Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes
Autor: Lyudmila Ounpuu, Aleksandr Klepinin, Kati Mado, Karoliina Heck, Tuuli Kaambre, Igor Shevchuk, Laura Truu, Vahur Valvere, Manana Kandashvili, Andrus Kaldma, Andre Koit, Anu Planken, Natalja Timohhina, Kersti Tepp, Vladimir Chekulayev
Publikováno v: Biochemistry and Biophysics Reports
The aim of the work was to evaluate whether or not there is glycolytic reprogramming in the neighboring cells of colorectal cancer (CRC). Using postoperative material we have compared the functional capacity of oxidative phosphorylation (OXPHOS) in C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80c7655175da3f88708ab7198992983
https://pubmed.ncbi.nlm.nih.gov/29124194
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8
An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome
Autor: Laura Truu, Kati Mado, Andrus Kaldma, Andre Koit, Kersti Tepp, Minna Varikmaa, Tuuli Kaambre, Egle Rebane, Igor Shevchuk, Karoliina Heck, Vladimir Chekulayev, Manana Kandashvili, Aleksandr Klepinin, Margus Planken, Vahur Valvere, Anu Planken, Natalja Timohhina
Publikováno v: The international journal of biochemistrycell biology. 55
The aim of this study is to characterize the function of mitochondria and main energy fluxes in human colorectal cancer (HCC) cells. We have performed quantitative analysis of cellular respiration in post-operative tissue samples collected from 42 ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eff9f470fa3421b59221c1b9bf312da
https://pubmed.ncbi.nlm.nih.gov/25218857
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