Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA.

Autor: Jiang AY; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Lathwal S; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Meng S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Witten J; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Beyer E; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., McMullen P; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Hu Y; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Manan RS; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Raji I; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts 02115, United States., Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts 02115, United States.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Anderson DG; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts 02115, United States.; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing.

Autor: Li B; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Manan RS; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Liang SQ; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA., Gordon A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Jiang A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Varley A; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Gao G; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.; Horae Gene Therapy Center and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA., Langer R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Xue W; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA. wen.xue@umassmed.edu.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA, USA. wen.xue@umassmed.edu., Anderson D; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, USA. dgander@mit.edu.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2023 Oct; Vol. 41 (10), pp. 1410-1415. Date of Electronic Publication: 2023 Mar 30.

Nucleic acid delivery for therapeutic applications.

Autor: Gupta A; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Andresen JL; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Manan RS; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Langer R; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: rlanger@mit.edu.

Publikováno v: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2021 Nov; Vol. 178, pp. 113834. Date of Electronic Publication: 2021 Sep 04.

Diastereoselective Synthesis of γ-Substituted 2-Butenolides via (CDC)-Rh-Catalyzed Intermolecular Hydroalkylation of Dienes with Silyloxyfurans.

Autor: Goldfogel MJ; Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States., Roberts CC; Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States., Manan RS; Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States., Meek SJ; Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.

Publikováno v: Organic letters [Org Lett] 2017 Jan 06; Vol. 19 (1), pp. 90-93. Date of Electronic Publication: 2016 Dec 20.

Nickel-catalyzed hydroimination of alkynes.

Autor: Manan RS; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58102, United States., Kilaru P; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58102, United States., Zhao P; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58102, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2015 May 20; Vol. 137 (19), pp. 6136-9. Date of Electronic Publication: 2015 May 05.