Swarm Learning for decentralized and confidential clinical machine learning

Autor: Warnat-Herresthal, Stefanie, Schultze, Hartmut, Ktena, Sofia, Franzenburg, Sören, Frick, Julia-Stefanie, Gabernet, Gisela, Gagneur, Julien, Ganzenmueller, Tina, Gauder, Marie, Geißert, Janina, Goesmann, Alexander, Göpel, Siri, Grundhoff, Adam, Tran, Florian, Grundmann, Hajo, Hain, Torsten, Hanses, Frank, Hehr, Ute, Heimbach, André, Hoeper, Marius, Horn, Friedemann, Hübschmann, Daniel, Hummel, Michael, Iftner, Thomas, Bitzer, Michael, Iftner, Angelika, Illig, Thomas, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keppler, Oliver T, Klein, Christoph, Knop, Michael, Kohlbacher, Oliver, Ossowski, Stephan, Köhrer, Karl, Korbel, Jan, Kremsner, Peter G, Kühnert, Denise, Landthaler, Markus, Li, Yang, Ludwig, Kerstin U, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice C, Casadei, Nicolas, Mertes, Christian, Münchhoff, Maximilian, Nahnsen, Sven, Nöthen, Markus M., Ntoumi, Francine, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Pink, Isabell, Poetsch, Anna R, Herr, Christian, Protzer, Ulrike, Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Reiche, Kristin, Ripke, Stephan, da Rocha, Ulisses Nunes, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Petersheim, Daniel, Scheithauer, Simone, Schiffer, Philipp, Schmid-Burgk, Jonathan, Schneider, Wulf, Schulte, Eva-Christina, Sczyrba, Alexander, Sharaf, Mariam L, Singh, Yogesh, Sonnabend, Michael, Stegle, Oliver, Behrends, Uta, Stoye, Jens, Vehreschild, Janne, Velavan, Thirumalaisamy P, Vogel, Jörg, Volland, Sonja, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Winkler, Sylke, Kern, Fabian, Ziebuhr, John, Fehlmann, Tobias, Shastry, Krishnaprasad Lingadahalli, Schommers, Philipp, Lehmann, Clara, Augustin, Max, Rybniker, Jan, Altmüller, Janine, Mishra, Neha, Bernardes, Joana P, Krämer, Benjamin, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Manamohan, Sathyanarayanan, De Domenico, Elena, Siever, Christian, Kraut, Michael, Desai, Milind, Monnet, Bruno, Saridaki, Maria, Siegel, Charles Martin, Drews, Anna, Nuesch Germano, Melanie, Theis, Heidi, Mukherjee, Saikat, Heyckendorf, Jan, Schreiber, Stefan, Kim-Hellmuth, Sarah, Study, COVID-19 Aachen, Nattermann, Jacob, Skowasch, Dirk, Kurth, Ingo, Keller, Andreas, Bals, Robert, Nürnberg, Peter, Garg, Vishesh, Rieß, Olaf, Rosenstiel, Philip, Netea, Mihai G, Theis, Fabian, Mukherjee, Sach, Backes, Michael, Aschenbrenner, Anna C, Ulas, Thomas, Initiative, Deutsche COVID-19 Omics, Breteler, Monique, Sarveswara, Ravi, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Becker, Matthias, Cheran, Sorin, Woodacre, Michael S, Goh, Eng Lim, Schultze, Joachim L, Balfanz, Paul, Eggermann, Thomas, Boor, Peter, Händler, Kristian, Hausmann, Ralf, Kuhn, Hannah, Isfort, Susanne, Stingl, Julia Carolin, Schmalzing, Günther, Kuhl, Christiane K, Röhrig, Rainer, Marx, Gernot, Uhlig, Stefan, Dahl, Edgar, Pickkers, Peter, Müller-Wieland, Dirk, Dreher, Michael, Marx, Nikolaus, Angelov, Angel, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Blumert, Conny, Bonifacio, Ezio, Bork, Peer, Aziz, Ahmad, Boyke, Bunk, Blum, Helmut, Clavel, Thomas, Colome-Tatche, Maria, Cornberg, Markus, De La Rosa Velázquez, Inti Alberto, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad

Publikováno v: Nature, 594(7862), 265-270. Nature Publishing Group
Nature
Nature, 594, 7862, pp. 265-270
Nature, 594, 265-270
Nature (2021)
Nature 594(7862), 265-270 (2021). doi:10.1038/s41586-021-03583-3

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec35177e99f77173021d0f7e89747def
https://research.rug.nl/en/publications/daf90693-3919-4802-8048-dd81b2a60169

Swarm Learning for decentralized and confidential clinical machine learning.

Autor: Warnat-Herresthal S; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Schultze H; Hewlett Packard Enterprise, Houston, TX, USA., Shastry KL; Hewlett Packard Enterprise, Houston, TX, USA., Manamohan S; Hewlett Packard Enterprise, Houston, TX, USA., Mukherjee S; Hewlett Packard Enterprise, Houston, TX, USA., Garg V; Hewlett Packard Enterprise, Houston, TX, USA.; Mesh Dynamics, Bangalore, India., Sarveswara R; Hewlett Packard Enterprise, Houston, TX, USA., Händler K; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Pickkers P; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands., Aziz NA; Population Health Sciences, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany., Ktena S; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Tran F; Department of Internal Medicine I, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Bitzer M; Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany., Ossowski S; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany., Casadei N; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany., Herr C; Department of Internal Medicine V, Saarland University Hospital, Homburg, Germany., Petersheim D; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU Munich, Munich, Germany., Behrends U; Children's Hospital, Medical Faculty, Technical University Munich, Munich, Germany., Kern F; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany., Fehlmann T; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany., Schommers P; Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Lehmann C; Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Augustin M; Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Rybniker J; Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Altmüller J; Cologne Center for Genomics, West German Genome Center, University of Cologne, Cologne, Germany., Mishra N; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Bernardes JP; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Krämer B; Clinical Infectious Diseases, Research Center Borstel and German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany., Bonaguro L; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Schulte-Schrepping J; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., De Domenico E; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Siever C; Hewlett Packard Enterprise, Houston, TX, USA., Kraut M; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Desai M; Hewlett Packard Enterprise, Houston, TX, USA., Monnet B; Hewlett Packard Enterprise, Houston, TX, USA., Saridaki M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Siegel CM; Hewlett Packard Enterprise, Houston, TX, USA., Drews A; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Nuesch-Germano M; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Theis H; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Heyckendorf J; Clinical Infectious Diseases, Research Center Borstel and German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany., Schreiber S; Department of Internal Medicine I, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Kim-Hellmuth S; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU Munich, Munich, Germany., Nattermann J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Braunschweig, Germany., Skowasch D; Department of Internal Medicine II - Cardiology/Pneumology, University of Bonn, Bonn, Germany., Kurth I; Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany., Keller A; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Bals R; Department of Internal Medicine V, Saarland University Hospital, Homburg, Germany., Nürnberg P; Cologne Center for Genomics, West German Genome Center, University of Cologne, Cologne, Germany., Rieß O; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany., Rosenstiel P; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Immunology & Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Theis F; Institute of Computational Biology, Helmholtz Center Munich (HMGU), Neuherberg, Germany., Mukherjee S; Statistics and Machine Learning, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany., Backes M; CISPA Helmholtz Center for Information Security, Saarbrücken, Germany., Aschenbrenner AC; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands., Ulas T; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Breteler MMB; Population Health Sciences, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Kox M; Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands., Becker M; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany., Cheran S; Hewlett Packard Enterprise, Houston, TX, USA., Woodacre MS; Hewlett Packard Enterprise, Houston, TX, USA., Goh EL; Hewlett Packard Enterprise, Houston, TX, USA., Schultze JL; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. joachim.schultze@dzne.de.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. joachim.schultze@dzne.de.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and the University of Bonn, Bonn, Germany. joachim.schultze@dzne.de.

Publikováno v: Nature [Nature] 2021 Jun; Vol. 594 (7862), pp. 265-270. Date of Electronic Publication: 2021 May 26.