Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Manami Shimomura"'
Autor:
Kohei Shitara, Satoshi Ueha, Shigeyuki Shichino, Hiroyasu Aoki, Haru Ogiwara, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Toshiaki Yoshikawa, Kayoko Shoda, Shigehisa Kitano, Makiko Yamashita, Takayuki Nakayama, Akihiro Sato, Sakiko Kuroda, Masashi Wakabayashi, Shogo Nomura, Shoji Yokochi, Satoru Ito, Kouji Matsushima, Toshihiko Doi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Transient CD4+ T cell depletion led to the proliferation of tumor-specific CD8+ T cells in the draining lymph node and increased infiltration of PD-1+CD8+ T cells into the tumor, which resulted in strong anti-tumor effects in tumo
Externí odkaz:
https://doaj.org/article/f3fa5960399a4030b38ca80859495c2b
Autor:
Norihiro Fujinami, Toshiaki Yoshikawa, Yu Sawada, Manami Shimomura, Tatsuaki Iwama, Shiori Sugai, Shigehisa Kitano, Yasushi Uemura, Tetsuya Nakatsura
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 482-491 (2016)
Purpose: The clinical efficacy of cancer peptide vaccine therapy is insufficient. To enhance the anti-tumor effect of peptide vaccine therapy, we combined this therapy with an anti-CD4 mAb (GK1.5), which is known to deplete CD4+ cells, including regu
Externí odkaz:
https://doaj.org/article/abe1098a9e3e4ddebc235da700710c18
Autor:
Nobuhiro Tsuchiya, Ako Hosono, Toshiaki Yoshikawa, Kayoko Shoda, Kazuto Nosaka, Manami Shimomura, Junichi Hara, Chika Nitani, Atsushi Manabe, Hiroki Yoshihara, Yosuke Hosoya, Hide Kaneda, Yoshiaki Kinoshita, Kenichi Kohashi, Kenichi Yoshimura, Norihiro Fujinami, Keigo Saito, Shoichi Mizuno, Tetsuya Nakatsura
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, phase I clinical trial, we analyzed the safety and efficacy of GPC3-peptid
Externí odkaz:
https://doaj.org/article/5f76819309494872a07ab5ff75f4dada
Autor:
Takanori Eguchi, Chiharu Sogawa, Yuka Okusha, Kenta Uchibe, Ryosuke Iinuma, Kisho Ono, Keisuke Nakano, Jun Murakami, Manabu Itoh, Kazuya Arai, Toshifumi Fujiwara, Yuri Namba, Yoshiki Murata, Kazumi Ohyama, Manami Shimomura, Hirohiko Okamura, Masaharu Takigawa, Tetsuya Nakatsura, Ken-Ichi Kozaki, Kuniaki Okamoto, Stuart K Calderwood
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191109 (2018)
Ability to form cellular aggregations such as tumorspheres and spheroids have been used as a morphological marker of malignant cancer cells and in particular cancer stem cells (CSC). However, the common definition of the types of cellular aggregation
Externí odkaz:
https://doaj.org/article/921dd99a06f24871ae74dcd1bd37fa52
Autor:
Kouji Matsushima, Toshihiko Doi, Satoru Ito, Makoto Kurachi, Masashi Wakabayashi, Sakiko Kuroda, Shigehisa Kitano, Makiko Yamashita, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Kohei Shitara, Haru Ogiwara, Shigeyuki Shichino, Satoshi Ueha, Hiroyasu Aoki
Supplementary Figures 1-7 Supplementary Table 1-8, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f00c420fe640f70ecd0d466cecff58
https://doi.org/10.1158/2326-6066.22543467.v1
https://doi.org/10.1158/2326-6066.22543467.v1
Autor:
Kouji Matsushima, Toshihiko Doi, Satoru Ito, Makoto Kurachi, Masashi Wakabayashi, Sakiko Kuroda, Shigehisa Kitano, Makiko Yamashita, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Kohei Shitara, Haru Ogiwara, Shigeyuki Shichino, Satoshi Ueha, Hiroyasu Aoki
Supplementary Table 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b354d002dc5543b981dd8dd6ea1f5afd
https://doi.org/10.1158/2326-6066.22543464.v1
https://doi.org/10.1158/2326-6066.22543464.v1
Autor:
Kouji Matsushima, Toshihiko Doi, Satoru Ito, Makoto Kurachi, Masashi Wakabayashi, Sakiko Kuroda, Shigehisa Kitano, Makiko Yamashita, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Kohei Shitara, Haru Ogiwara, Shigeyuki Shichino, Satoshi Ueha, Hiroyasu Aoki
Antibody-mediated transient depletion of CD4+ cells enhances the expansion of tumor-reactive CD8+ T cells and exhibits robust antitumor effects in preclinical and clinical studies. To investigate the clonal T-cell responses following transient CD4+ c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5937c3a4d816350c0307d5a91e1283e8
https://doi.org/10.1158/2326-6066.c.6550272
https://doi.org/10.1158/2326-6066.c.6550272
Autor:
Hiroaki Kajiyama, Kazuhisa Kitami, Manami Shimomura, Toshiaki Yoshikawa, Kazuto Nosaka, Fumitaka Kikkawa, Shiro Suzuki, Kosuke Yoshida, Tetsuya Nakatsura, Masato Yoshihara
Publikováno v:
Anticancer Research. 41:4741-4751
Background/aim Heat shock protein 105 (HSP105) is overexpressed in various cancers, but not in normal tissues. We investigated the expression levels of HSP105 in cervical cancer and the efficacy of immunotherapy targeting HSP105. Materials and method
Publikováno v:
Journal of Hepatocellular Carcinoma
Primary liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide. After surgery, up to 70% of patients experience relapses. The current first-line therapy for advanced cases of hepatocell
Autor:
Shigeyuki Shichino, Hiromichi Nakajima, Yoshiaki Nakamura, Tetsuya Nakatsura, Satoshi Ueha, Manami Shimomura, Hiroyasu Aoki, Akihiro Sato, Kouji Matsushima, Takayuki Yoshino
Publikováno v:
Cancer Science
With the widespread use of programmed death receptor‐1 (PD‐1) blockade therapy, sensitive and specific predictive biomarkers that guide patient selection are urgently needed. T‐cell receptor (TCR) repertoire, which reflects antitumor T‐cell r