Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Manami Hara"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011617 (2023)
The islets of Langerhans are critical endocrine micro-organs that secrete hormones regulating energy metabolism in animals. Insulin and glucagon, secreted by beta and alpha cells, respectively, are responsible for metabolic switching between fat and
Externí odkaz:
https://doaj.org/article/0bc03a2e37d74b8bba0b9fcb2130c8c3
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
An increasing number of studies have demonstrated that disease states of the endocrine or exocrine pancreas aggravate one another, which implies bidirectional blood flow between islets and exocrine cells. However, this is inconsistent with the curren
Externí odkaz:
https://doaj.org/article/7432a120229740468214df6532bc2d48
Publikováno v:
iScience, Vol 21, Iss , Pp 612-623 (2019)
Summary: Body mass index (BMI) is commonly used to define obesity. However, concerns about its accuracy in predicting adiposity have been raised. The feasibility of using BMI as well as waist-height ratio (WHtR) in assessing adiposity was examined in
Externí odkaz:
https://doaj.org/article/8e9e1249b9bd4420907fbcf9453ca483
Autor:
Michael P. Dybala, Manami Hara
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The pancreas is regarded as consisting of two separate organ systems, the endocrine and exocrine pancreas. While treatment of a disease with either an endocrine or exocrine pathogenesis may affect the function of the entire pancreas, the pancreatic d
Externí odkaz:
https://doaj.org/article/430f02905b264329ba96bcd6c6de3a3a
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 2032-2042 (2015)
Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β cell function. However, little is known about the positive- and negative-acting coregulators recruited to mediate transcriptional control. Here, we isol
Externí odkaz:
https://doaj.org/article/d73ab065de174678b8b08d5f07816696
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152446 (2016)
Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; β and α cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while the rol
Externí odkaz:
https://doaj.org/article/a23ffffc5bf54b23bd13cc7c319ce674
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004423 (2015)
Pancreatic islets of Langerhans consist of endocrine cells, primarily α, β and δ cells, which secrete glucagon, insulin, and somatostatin, respectively, to regulate plasma glucose. β cells form irregular locally connected clusters within islets t
Externí odkaz:
https://doaj.org/article/42a5f65e99ee4351aa7bc438b92de83f
Publikováno v:
BioTechniques, Vol 39, Iss 3, Pp 373-376 (2005)
We describe a method to visualize green fluorescent protein (GFP)-labeled cells in intact organs through combined confocal and reflected laser light imaging. This method allows us a three-dimensional (3-D) view of specific cell types in situ. Imaging
Externí odkaz:
https://doaj.org/article/fa134756642d4eeeaadc3c2a57b96a42
Autor:
Danh-Tai Hoang, Hitomi Matsunari, Masaki Nagaya, Hiroshi Nagashima, J Michael Millis, Piotr Witkowski, Vipul Periwal, Manami Hara, Junghyo Jo
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110384 (2014)
Morphogenesis, spontaneous formation of organism structure, is essential for life. In the pancreas, endocrine α, β, and δ cells are clustered to form islets of Langerhans, the critical micro-organ for glucose homeostasis. The spatial organization
Externí odkaz:
https://doaj.org/article/c7251a5acf274f8494548468db7151ee
Autor:
Xiaojun Wang, Mark C Zielinski, Ryosuke Misawa, Patrick Wen, Tian-Yuan Wang, Cheng-Zhang Wang, Piotr Witkowski, Manami Hara
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55501 (2013)
The pancreatic islet is mainly composed of beta-, alpha- and delta-cells with small numbers of pancreatic polypeptide (PP) and epsilon cells. It is known that there is a region in the head of the pancreas that is rich in PP-cells. In the present stud
Externí odkaz:
https://doaj.org/article/6bd9cf04fadc4e50be41bf66d168c770