Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Manali Rupji"'
Autor:
Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Ide
Externí odkaz:
https://doaj.org/article/0c944d44150c49a0b8aca89a9d8db85d
Autor:
Jean L. Koff, Geeta M. Karadkhele, Jeffrey M. Switchenko, Manali Rupji, Kendra Little, Christian P. Larsen
Publikováno v:
Frontiers in Transplantation, Vol 2 (2024)
IntroductionPost-transplant lymphoproliferative disorder (PTLD) is a rare but life-threatening malignancy that arises in the setting of immunosuppression (IS) after solid organ transplant. IS regimens containing belatacept have been associated with a
Externí odkaz:
https://doaj.org/article/042473374dc5455699f6bdc6b4ce0fd7
Autor:
Sarah A. Westergaard, Manali Rupji, Lauren E. Franklin, Madhusmita Behera, Suresh S. Ramalingam, Kristin A. Higgins
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7339-7347 (2023)
Abstract Introduction Tobacco cessation is a critical but challenging intervention for cancer patients. Our National Cancer Institute‐designated Comprehensive Cancer Center instituted a tobacco cessation program in 2019. This manuscript reports on
Externí odkaz:
https://doaj.org/article/a2b1f08bf59b49508a2109caf908f457
Autor:
Gregory B Lesinski, Christina Wu, Mehmet Akce, Brian Olson, Maria Diab, Batoul Farran, Jeffrey M Switchenko, Manali Rupji, Sandra Kang, Lana Khalil, Amanda Ruggieri-Joyce, Walid L Shaib, Olatunji B Alese, Bassel F El-Rayes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Preclinical studies showed metformin reduces exhaustion of tumor-infiltrating lymphocytes and potentiates programmed cell death protein-1 (PD-1) blockade. We hypothesized that metformin with nivolumab would elicit potent antitumor and immu
Externí odkaz:
https://doaj.org/article/2bc4352546204629923aab3d10545a4e
Autor:
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL
Externí odkaz:
https://doaj.org/article/2dbae7c4d3ee43d79487bfe5ab1bc1e6
Autor:
Briana Rackley, Chang-Soo Seong, Evan Kiely, Rebecca E. Parker, Manali Rupji, Bhakti Dwivedi, John M. Heddleston, William Giang, Neil Anthony, Teng-Leong Chew, Melissa Gilbert-Ross
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to t
Externí odkaz:
https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
Autor:
Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with I
Externí odkaz:
https://doaj.org/article/ab542c51a366402d8b83cd98c687f243
Autor:
Ju Young Kim, Dong Hun Lee, Joo Kyung Kim, Hong Seo Choi, Bhakti Dwivedi, Manali Rupji, Jeanne Kowalski, Stefan J. Green, Heesang Song, Won Jong Park, Ji Young Chang, Tae Min Kim, Changwon Park
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-9 (2019)
Abstract Previous studies including ours have demonstrated a critical function of the transcription factor ETV2 (ets variant 2; also known as ER71) in determining the fate of cardiovascular lineage development. However, the underlying mechanisms of E
Externí odkaz:
https://doaj.org/article/eb7e411c210d4eb59aa3d1d1a430a5dc
Autor:
Benjamin I Siegel, Tricia Z King, Manali Rupji, Bhakti Dwivedi, Alexis B Carter, Jeanne Kowalski, Tobey J MacDonald
Publikováno v:
Translational Oncology, Vol 12, Iss 7, Pp 908-916 (2019)
Host genome analysis is a promising source of predictive information for long-term morbidity in cancer survivors. However, studies on genetic predictors of long-term outcome, particularly neurocognitive function following chemoradiation in pediatric
Externí odkaz:
https://doaj.org/article/5249a9fec3484d04ab73812c2d6e6b73
Autor:
Subhas Mukherjee, Carol Tucker-Burden, Emily Kaissi, Austin Newsam, Hithardhi Duggireddy, Monica Chau, Changming Zhang, Bhakti Diwedi, Manali Rupji, Sandra Seby, Jeanne Kowalski, Jun Kong, Renee Read, Daniel J. Brat
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1651-1664 (2018)
Summary: Cancer stem cells promote neoplastic growth, in part by deregulating asymmetric cell division and enhancing self-renewal. To uncover mechanisms and potential therapeutic targets in glioma stem cell (GSC) self-renewal, we performed a genetic
Externí odkaz:
https://doaj.org/article/7bc068c2e26b46b282acc6c511b8b001