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Long non-coding RNAs (lncRNAs) regulate diverse cellular processes and are associated with many age-associated diseases. However, the function of lncRNAs in cellular senescence remains largely unknown. Here we characterize the role of lncRNA H19 in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b181fb7dfa413dfde29f7af153138c
https://doi.org/10.1101/2022.07.07.499142
https://doi.org/10.1101/2022.07.07.499142
Autor:
Timothy Nacarelli, Ashley Azar, Manali Potnis, Gregg Johannes, Joshua Mell, F. Brad Johnson, Holly Brown-Borg, Eishi Noguchi, Christian Sell
Publikováno v:
Molecular biology of the cell. 33(5)
Cellular senescence is a terminal cell fate characterized by growth arrest and a metabolically active state characterized by high glycolytic activity. Human fibroblasts were placed in a unique metabolic state using a combination of methionine restric
Autor:
Christina Lee Chung, Ibiyonu Lawrence, Melissa Hoffman, Manali Potnis, Christian Sell, Kumar S. Nadhan, Catlin Sershon, Dareen Elgindi, Annie Jin, Antonello Lorenzini, Rhonda Binnebose
Publikováno v:
GeroScience
Aging is a major risk factor for the majority of human diseases, and the development of interventions to reduce the intrinsic rate of aging is expected to reduce the risk for age-related diseases including cardiovascular disease, cancer, and dementia
Autor:
Manali Potnis, Christian Sell
Publikováno v:
Innovation in Aging
The long non-coding RNA (lncRNA) H19 is a maternally imprinted gene transcript that, in conjunction with the neighboring Igf2 gene, is critical in controlling embryonic growth. Loss of H19 results in fetal overgrowth associated with Beckwith Weideman
Publikováno v:
Innovation in Aging
Cellular senescence is a cell fate defined by an irreversible cell-cycle arrest and a pro-inflammatory secretory profile. It is a consequence of a shift in metabolism and rearrangement of chromatin. Accumulation of senescent cells is a universal hall