Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Manal Zabalawi"'
Autor:
Allison K. Meyers, Zhan Wang, Wenzheng Han, Qingxia Zhao, Manal Zabalawi, Likun Duan, Juan Liu, Qianyi Zhang, Rajesh K. Manne, Felipe Lorenzo, Matthew A. Quinn, Qianqian Song, Daping Fan, Hui-Kuan Lin, Cristina M. Furdui, Jason W. Locasale, Charles E. McCall, Xuewei Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111941- (2023)
Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) signif
Externí odkaz:
https://doaj.org/article/9e44575ee34a4202a7a3e462e4561170
Autor:
Tae Seok Oh, Manal Zabalawi, Shalini Jain, David Long, Peter W. Stacpoole, Charles E. McCall, Matthew A. Quinn
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection. The metabolic aberrations associated with sepsis underly an acute and organism-wide hyperinflammatory response and multiple organ dysfunction; howeve
Externí odkaz:
https://doaj.org/article/5d981fcaf4444ba598df155e5fb19c2a
Autor:
Qingxia Zhao, Zhan Wang, Allison K. Meyers, Jennifer Madenspacher, Manal Zabalawi, Qianyi Zhang, Elena Boudyguina, Fang-Chi Hsu, Charles E. McCall, Cristina M. Furdui, John S. Parks, Michael B. Fessler, Xuewei Zhu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Macrophages play a central role in the pathogenesis of atherosclerosis. Our previous study demonstrated that solute carrier family 37 member 2 (SLC37A2), an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate transporter, negatively r
Externí odkaz:
https://doaj.org/article/faf5fd19e0c94aa199d2c274dfbde07e
Autor:
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S Parks, Cristina Furdui, Peter W Stacpoole, Jennifer Martinez, Charles E McCall, Matthew A Quinn
Publikováno v:
eLife, Vol 10 (2021)
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming ensures surv
Externí odkaz:
https://doaj.org/article/54dd853ae26241009d6cb06d0d6d3a95
Autor:
Zhan Wang, Qingxia Zhao, Yan Nie, Yi Yu, Biswapriya B. Misra, Manal Zabalawi, Jeff W. Chou, Chia-Chi C. Key, Anthony J. Molina, Matthew A. Quinn, Michael B. Fessler, John S. Parks, Charles E. McCall, Xuewei Zhu
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Increased flux of glucose through glycolysis is a hallmark of inflammatory macrophages and is essential for optimal effector functions. Solute carrier (SLC) 37A2 is an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate trans
Externí odkaz:
https://doaj.org/article/5cfa8e8902044865933594eb473988ea
Autor:
Hagai Tavori, Yan Ru Su, Patricia G. Yancey, Ilaria Giunzioni, Ashley J. Wilhelm, John L. Blakemore, Manal Zabalawi, MacRae F. Linton, Mary G. Sorci-Thomas, Sergio Fazio
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 635-643 (2015)
Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main protein, apoAI, are acceptors of excess cholesterol from macrophages; this process inhibits tiss
Externí odkaz:
https://doaj.org/article/4b91fe2d8a4a4c96a386e6e5b802fffd
Autor:
Charles E McCall, Xuewei Zhu, Manal Zabalawi, David Long, Matthew A Quinn, Barbara K Yoza, Peter W Stacpoole, Vidula Vachharajani
Publikováno v:
Journal of leukocyte biologyREFERENCES. 112(6)
Balancing high energy-consuming danger resistance and low energy supply of disease tolerance is a universal survival principle that often fails during sepsis. Our research supports the concept that sepsis phosphorylates and deactivates mitochondrial
Autor:
Sushma Kaul, Hao Xu, Manal Zabalawi, Elisa Maruko, Brian E. Fulp, Theresa Bluemn, Kristina L. Brzoza‐Lewis, Mark Gerelus, Ranjuna Weerasekera, Rachel Kallinger, Roland James, Yi (Sherry) Zhang, Michael J. Thomas, Mary G. Sorci‐Thomas
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 11 (2016)
BackgroundAtherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high‐density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high‐density lipoprote
Externí odkaz:
https://doaj.org/article/a33c31fe04944af48f938752dc8a1d56
Autor:
Manal Zabalawi, Russel C. Sequeira, Yan Nie, Xuewei Zhu, Elena Boudyguina, Tiantong Ou, Jennifer H. Madenspacher, Qingxia Zhao, Zhan Wang, Jonathan M. Nelson, Michael B. Fessler
Publikováno v:
Atherosclerosis
Background and aims Dietary long-chain (≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when compari
Autor:
Mary G. Sorci-Thomas, John S. Owen, Brian Fulp, Shaila Bhat, Xuewei Zhu, John S. Parks, Dharika Shah, W. Gray Jerome, Mark Gerelus, Manal Zabalawi, Michael J. Thomas
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 9, Pp 1890-1909 (2012)
This report details the lipid composition of nascent HDL (nHDL) particles formed by the action of the ATP binding cassette transporter A1 (ABCA1) on apolipoprotein A-I (apoA-I). nHDL particles of different size (average diameters of ∼12, 10, 7.5, a
Externí odkaz:
https://doaj.org/article/4b77553386ea41c191081ca166d4443b