Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Manal S Zaher"'
Autor:
Fahad Rashid, Paul D Harris, Manal S Zaher, Mohamed A Sobhy, Luay I Joudeh, Chunli Yan, Hubert Piwonski, Susan E Tsutakawa, Ivaylo Ivanov, John A Tainer, Satoshi Habuchi, Samir M Hamdan
Publikováno v:
eLife, Vol 6 (2017)
Human flap endonuclease 1 (FEN1) and related structure-specific 5’nucleases precisely identify and incise aberrant DNA structures during replication, repair and recombination to avoid genomic instability. Yet, it is unclear how the 5’nuclease mec
Externí odkaz:
https://doaj.org/article/c2bf0645a5a649bf9e61091200d14830
Autor:
Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structur
Externí odkaz:
https://doaj.org/article/782ada8b374241e2b47934138793c3f7
Autor:
Fahad Rashid, Vlad-Stefan Raducanu, Manal S. Zaher, Muhammad Tehseen, Satoshi Habuchi, Samir M. Hamdan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Protein-induced fluorescence enhancement (PIFE) is a popular tool for characterizing protein-DNA interactions. Here, authors provide a perspective on understanding the general phenomenon of induced fluorescence modulation
Externí odkaz:
https://doaj.org/article/10e5b504413c4b409b65d627290c34fe
Publikováno v:
Nucleic Acids Research
When vertebrate replisomes from neighboring origins converge, the Mcm7 subunit of the replicative helicase, CMG, is ubiquitylated by the E3 ubiquitin ligase, CRL2Lrr1. Polyubiquitylated CMG is then disassembled by the p97 ATPase, leading to replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f960fe6f14e70c50ae06700e797d43d
https://doi.org/10.1093/nar/gkab1174
https://doi.org/10.1093/nar/gkab1174
Publikováno v:
Genes Dev
When converging replication forks meet during replication termination, the CMG (Cdc45–MCM2–7–GINS) helicase is polyubiquitylated by CRL2Lrr1 and unloaded from chromatin by the p97 ATPase. Here, we investigate the signal that triggers CMG unload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f437957d4f76e8845d4c7d66cad33e5
https://doi.org/10.1101/gad.339739.120
https://doi.org/10.1101/gad.339739.120
Autor:
Vlad-Stefan Raducanu, Muhammad Tehseen, Nekane Merino, Afnan Shirbini, Francisco J. Blanco, Alfredo De Biasio, Fahad Rashid, Manal S. Zaher, Claudia Lancey, Samir M. Hamdan, Timothy J. Ragan, Christos G. Savva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520ed1b2412fe299f96b7d178fbcc23b
http://link.springer.com/article/10.1038/s41467-020-14898-6
http://link.springer.com/article/10.1038/s41467-020-14898-6
Autor:
Samir M. Hamdan, Amer Bralic, Fahad Rashid, Vlad-Stefan Raducanu, Muhammad Tehseen, Mohamed Abdelmaboud Sobhy, Yujing Ouyang, Manal S. Zaher, Masateru Takahashi
Publikováno v:
Journal of Visualized Experiments.
Bulk methods measure the ensemble behavior of molecules, in which individual reaction rates of the underlying steps are averaged throughout the population. Single-molecule Förster resonance energy transfer (smFRET) provides a recording of the confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb27a422be41b9c596cf939b17e0cba
https://doi.org/10.3791/60045
https://doi.org/10.3791/60045
Autor:
Samir M. Hamdan, Fahad Rashid, Muhammad Tehseen, Manal S. Zaher, Vlad-Stefan Raducanu, Satoshi Habuchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Protein-induced fluorescence enhancement (PIFE) is a popular tool for characterizing protein-DNA interactions. PIFE has been explained by an increase in local viscosity due to the presence of the protein residues. This explanation, however, denies th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a556dbb241dd3fd1ad03ec7881ed5365
https://doi.org/10.1038/s41467-019-10137-9
https://doi.org/10.1038/s41467-019-10137-9
Autor:
Masateru Takahashi, Samir M. Hamdan, Muhammad Tehseen, Amer Bralic, Fahad Rashid, Vlad-Stefan Raducanu, Manal S. Zaher, Mohamed Abdelmaboud Sobhy
Publikováno v:
Nucleic Acids Research
Human GEN1 is a cytosolic homologous recombination protein that resolves persisting four-way Holliday junctions (HJ) after the dissolution of the nuclear membrane. GEN1 dimerization has been suggested to play key role in the resolution of the HJ, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9252e6e5d640f9157efb1768ad4b6cb
https://pubmed.ncbi.nlm.nih.gov/30590761
https://pubmed.ncbi.nlm.nih.gov/30590761
Autor:
Vlad-Stefan Raducanu, Jasmeen S. Merzaban, Manal S. Zaher, Yanyan Li, Fahad Rashid, Samir M. Hamdan
Publikováno v:
Sensors and Actuators B: Chemical. 304:127376
Using DNA aptamers as sensors for metal ions provide a variety of applications in biology and industry. Many of these sensors are based on guanine-rich DNA sequences that undergo conformational changes upon metal-ion binding. However, these sensors r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df3d79844d1561fdb2a7b7fb3b2093e3
https://doi.org/10.1016/j.snb.2019.127376
https://doi.org/10.1016/j.snb.2019.127376