Výsledky vyhledávání - "Manal N. S. Saudi"

Design, synthesis and molecular modeling studies of new series of antitumor 1,2,4-triazines with potential c-Met kinase inhibitory activity

Autor: Marwa H. El-Wakil, Manal N. S. Saudi, Hayam M. A. Ashour, Ahmed Hassan, Ibrahim M. Labouta

Publikováno v: Bioorganic Chemistry. 76:154-165

The receptor tyrosine kinase c-Met is an attractive target for therapeutic treatment of cancers nowadays. Herein we describe the design and synthesis of a novel series of 1,2,4-triazine derivatives based on our lead NCI 748494/1, possessing different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496242691dd78ee3b5390c79fecdf067
https://doi.org/10.1016/j.bioorg.2017.11.006

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Target identification, lead optimization and antitumor evaluation of some new 1,2,4-triazines as c-Met kinase inhibitors

Autor: Hayam M. A. Ashour, Ibrahim M. Labouta, Manal N. S. Saudi, Ahmed Hassan, Marwa H. El-Wakil

Publikováno v: Bioorganic Chemistry. 73:154-169

In silico target fishing approach using PharmMapper server identified c-Met kinase as the selective target for our previously synthesized compound NCI 748494/1. This approach was validated by in vitro kinase assay which showed that NCI 748494/1 posse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564fadc8b1c0880532339a04300e12a7
https://doi.org/10.1016/j.bioorg.2017.06.009

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Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies

Autor: Dharmarajan Sriram, Yasser S. Abdel-Ghany, Perihan A. Elzahhar, Soad A.M. El-Hawash, Rasha A. Nassra, Manal N. S. Saudi, Nayera W. Hassan, Marwa M. Abdel-Aziz, Azza Ismail

Publikováno v: Bioorganic Chemistry. 96:103610

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moiet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd163f760335440fa3a05822b950ac0
https://doi.org/10.1016/j.bioorg.2020.103610

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Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents

Autor: Sherry N. Nasralla, Tamer M. Ibrahim, Ahmed M. M. Hassan, Alaa El-Din A. Bekhit, Manal N. S. Saudi, Aya M. El-Seidy, Salwa M. Fahmy, Adnan A. Bekhit, Doaa A. Ghareeb

Publikováno v: European journal of medicinal chemistry. 163

New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent antiplasmodial agents against P. berghei with percent of suppression ranging from 90 to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd542030045c89dd7556fe05bb3db5d
https://pubmed.ncbi.nlm.nih.gov/30530172

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Synthesis, molecular modeling and biological screening of some pyrazole derivatives as antileishmanial agents

Autor: Huda J Habib, Salwa M. Fahmy, Manal N. S. Saudi, Alaa El-Din A. Bekhit, Adnan A. Bekhit, Aya M. El-Seidy, Sayed Mahmood Alqallaf, Tamer M. Ibrahim, Doaa A. Ghareeb, Ahmed Mm Hassan

Publikováno v: Future medicinal chemistry. 10(19)

Aim: Novel open chain and cyclized derivatives containing pyrazole scaffold were designed, synthesized and evaluated as antileishmanial compounds. Methodology & results: In silico reverse docking experiment suggested Leishmania major pteridine reduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f83d49ac91bf5bef80bb72dfaced169
https://pubmed.ncbi.nlm.nih.gov/30215271

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Synthesis and biological evaluation of a novel class as antileishmanial agent

Autor: M. I. Jaeda, Mona M. El-Semary, Rasha Y. Elbayaa, Manal N. S. Saudi, Maha M. Eissa, Nahed M. Baddour, Eglal I. Amer

Publikováno v: Medicinal Chemistry Research. 21:257-267

Leishmaniases are a group of diseases caused by the protozoan parasites of the genus Leishmania. Despite the tremendous progress made in the understanding of the biochemistry and molecular biology of the parasite, the first choice treatment for leish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830ad99036d3d3ffc3330af4e5e42a89
https://doi.org/10.1007/s00044-010-9532-x

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Novel potential nonsedating H1 antagonists related to the gauche rotamer of PROS-NH-histamine

Autor: Rasha Y. Elbayaa, R. M. Shafik, Mona M. El-Semary, Manal N. S. Saudi, Farid S. G. Soliman

Publikováno v: Medicinal Chemistry Research. 18:187-205

On the basis of the most stable stereorotameric (R) forms of πNH-histamine (2), the trans (1-TR) and gauche (1-GR) forms have both been reported to be involved in potentiation of H1-receptors. Apart from the known classic models of H1-antagonists th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd57ab0a72fcaeb20d6e29bdf551bb6
https://doi.org/10.1007/s00044-008-9119-y

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