Výsledky vyhledávání - "Manal M. Alanazi"

Akademický článek

Theoretical study of the antioxidant mechanism and structure-activity relationships of 1,3,4-oxadiazol-2-ylthieno[2,3-d]pyrimidin-4-amine derivatives: a computational approach

Autor: Ahmed H. Bakheit, Tanveer A. Wani, Abdulrahman A. Al-Majed, Hamad M. Alkahtani, Manal M. Alanazi, Fahad Rubayyi Alqahtani, Seema Zargar

Publikováno v: Frontiers in Chemistry, Vol 12 (2024)

A theoretical thermodynamic study was conducted to investigate the antioxidant activity and mechanism of 1,3,4-oxadiazol-2-ylthieno[2,3-d]pyrimidin-4-amine derivatives (OTP) using a Density Functional Theory (DFT) approach. The study assessed how sol

Externí odkaz: https://doaj.org/article/bb2e40c580bf4c75b7e0824bbdccf355

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Akademický článek

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers

Autor: Nawaf A. Alsaif, Mohammed S. Taghour, Mohammed M. Alanazi, Ahmad J. Obaidullah, Abdulrahman A. Al-Mehizia, Manal M. Alanazi, Saleh Aldawas, Alaa Elwan, Hazem Elkady

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1093-1114 (2021)

Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised derivatives were biologically investigated for their cytotoxic activities against HepG2 and MCF-7. Als

Externí odkaz: https://doaj.org/article/3967d8ed03e940f084313220d5cd06f9

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New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies

Autor: Mohammed M. Alanazi, Ahmad J. Obaidullah, Nawaf A. Alsaif, Madhawi A. Alharbi, Manal M. Alanazi, Ibrahim H. Eissa, Hamad M. Alkahtani, Mohammed A. Dahab, Hazem Elkady

Publikováno v: RSC Advances. 11:30315-30328

A new series of 3-methylquinoxaline-based derivatives having the same essential pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against two human cancer cell lines, MCF-7 and He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5680056635b8abdbaa3f6952f2054da
https://doi.org/10.1039/d1ra05925d

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New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis

Autor: Abdulrahman A. Almehizia, Mohammed A. Dahab, Ahmad J. Obaidullah, Hazem A. Mahdy, Nawaf A. Alsaif, Hazem Elkady, Saleh Aldawas, Manal M. Alanazi, Mohammed M. Alanazi

Publikováno v: Bioorganic Chemistry. 110:104807

New series of [1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one and [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized, and biologically assessed for their anti-proliferative activities against two selected tumor cell lines MCF-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f780568b687319d2f2823183be0f7e9c
https://doi.org/10.1016/j.bioorg.2021.104807

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