Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Manal A Swairjo"'
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 3 (2012)
Purpose: The extent of palmitate uptake by hepatocytes is dependent upon the surface charge of the extracellular binding protein. Specifically, hepatocyte uptake is greater when palmitate is bound to cationic binding proteins than when it is bound to
Externí odkaz:
https://doaj.org/article/92fb3e77ce2f4ee9877c31e4d1bf373e
Autor:
Diana Y. Lee, Caitlin Bartels, Katelyn McNair, Robert A. Edwards, Manal A. Swairjo, Antoni Luque
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 721-732 (2022)
Tailed phages are viruses that infect bacteria and are the most abundant biological entities on Earth. Their ecological, evolutionary, and biogeochemical roles in the planet stem from their genomic diversity. Known tailed phage genomes range from 10
Externí odkaz:
https://doaj.org/article/bb9fd56f2c484fccadd66958287af1a4
Autor:
Samanthi Herath Gedara, Evan Wood, Andrew Gustafson, Cui Liang, Shr-Hau Hung, Joshua Savage, Phuc Phan, Amit Luthra, Valérie de Crécy-Lagard, Peter Dedon, Manal A Swairjo, Dirk Iwata-Reuyl
Publikováno v:
Nucleic Acids Research. 51:3836-3854
The modified nucleosides 2′-deoxy-7-cyano- and 2′-deoxy-7-amido-7-deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the products of the bacterial queuosine tRNA modification pathway and the dpd gene cluster, the latter
Autor:
Shr-Hau Hung, Gregory I Elliott, Thakku R Ramkumar, Lyubomyr Burtnyak, Callum J McGrenaghan, Sana Alkuzweny, Samia Quaiyum, Dirk Iwata-Reuyl, Xiaobei Pan, Brian D Green, Vincent P Kelly, Valérie de Crécy-Lagard, Manal A Swairjo
Publikováno v:
Hung, S-H, Elliott, G I, Ramkumar, T R, Burtnyak, L, McGrenaghan, C J, Alkuzweny, S, Quaiyum, S, Iwata-Reuyl, D, Pan, X, Green, B D, Kelly, V P, de Crécy-Lagard, V & Swairjo, M A 2023, ' Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate ', Nucleic Acids Research, vol. 51, no. 2, pp. 935–951 . https://doi.org/10.1093/nar/gkac1231
Eukaryotic life benefits from—and ofttimes critically relies upon—the de novo biosynthesis and supply of vitamins and micronutrients from bacteria. The micronutrient queuosine (Q), derived from diet and/or the gut microbiome, is used as a source
Autor:
Valérie de Crécy-Lagard, Manal A. Swairjo, Jo Marie Bacusmo, Christopher Deutsch, Dirk Iwata-Reuyl, William Swinehart, Amit Luthra, Paul F. Agris, Kathryn L. Sarachan
Publikováno v:
RNA. 26:1094-1103
N6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to AUG and suppress frameshifting at tandem ANN co
Autor:
Sylvain Moineau, Liang Cui, Peter C. Dedon, Tue Kjærgaard Nielsen, Geoffrey Hutinet, Lars Hestbjerg Hansen, Manal A. Swairjo, Nikoline S. Olsen, Valérie de Crécy-Lagard, Alexander Byth Carstens, Witold Kot
Publikováno v:
Kot, W, Olsen, N S, Nielsen, T K, Hutinet, G, de Crécy-Lagard, V, Cui, L, Dedon, P C, Carstens, A B, Moineau, S, Swairjo, M A & Hansen, L H 2020, ' Detection of preQ 0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs ', Nucleic Acids Research, vol. 48, no. 18, pp. 10383-10396 . https://doi.org/10.1093/nar/gkaa735
Kot, W, Olsen, N S, Nielsen, T K, Hutinet, G, de Crecy-Lagard, V, Cui, L, Dedon, P C, Carstens, A B, Moineau, S, Swairjo, M A & Hansen, L H 2020, ' Detection of preQ 0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs ', Nucleic Acids Symposium Series, vol. 48, no. 18, pp. 10383-10396 . https://doi.org/10.1093/nar/gkaa735
Nucleic Acids Research
Kot, W, Olsen, N S, Nielsen, T K, Hutinet, G, de Crecy-Lagard, V, Cui, L, Dedon, P C, Carstens, A B, Moineau, S, Swairjo, M A & Hansen, L H 2020, ' Detection of preQ 0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs ', Nucleic Acids Symposium Series, vol. 48, no. 18, pp. 10383-10396 . https://doi.org/10.1093/nar/gkaa735
Nucleic Acids Research
In the constant evolutionary battle against mobile genetic elements (MGEs), bacteria have developed several defense mechanisms, some of which target the incoming, foreign nucleic acids e.g. restriction-modification (R-M) or CRISPR-Cas systems. Some o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a2d52f1da8c6c7688c9e9fb9d5ab94
https://pure.au.dk/portal/da/publications/detection-of-preq0-deazaguanine-modifications-in-bacteriophage-cajan-dna-using-nanopore-sequencing-reveals-same-hypermodification-at-two-distinct-dna-motifs(312622ab-1976-4b3a-a198-2fa16fa64494).html
https://pure.au.dk/portal/da/publications/detection-of-preq0-deazaguanine-modifications-in-bacteriophage-cajan-dna-using-nanopore-sequencing-reveals-same-hypermodification-at-two-distinct-dna-motifs(312622ab-1976-4b3a-a198-2fa16fa64494).html
Autor:
William, Swinehart, Christopher, Deutsch, Kathryn L, Sarachan, Amit, Luthra, Jo Marie, Bacusmo, Valérie, de Crécy-Lagard, Manal A, Swairjo, Paul F, Agris, Dirk, Iwata-Reuyl
Publikováno v:
RNA
N(6)-threonylcarbamoyl adenosine (t(6)A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to AUG and suppress frameshifting at tandem AN
Autor:
Susan Bayooz, Manal A. Swairjo, Boguslaw Stec, William Swinehart, Jamie M. Schiffer, Naduni Paranagama, Dirk Iwata-Reuyl, Vanessa Quach, Amit Luthra, Phuc Phan
Publikováno v:
Nucleic Acids Research
The universally conserved N6-threonylcarbamoyladenosine (t6A) modification of tRNA is essential for translational fidelity. In bacteria, t6A biosynthesis starts with the TsaC/TsaC2-catalyzed synthesis of the intermediate threonylcarbamoyl adenylate (
Autor:
Daniel J. Payan, Sara Šepić, Steven C. Almo, Valérie de Crécy-Lagard, Peter C. Dedon, John A. Gerlt, Vinod Gadi, Manal A. Swairjo, Isabelle Martin-Verstraete, Yifeng Yuan, Seetharamsing Balamkundu, Ramesh Neelakandan, Chuan Fa Liu, Rémi Zallot, Tyler L. Grove
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (38), pp.19126-19135. ⟨10.1073/pnas.1909604116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (38), pp.19126-19135. ⟨10.1073/pnas.1909604116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (38), pp.19126-19135. ⟨10.1073/pnas.1909604116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (38), pp.19126-19135. ⟨10.1073/pnas.1909604116⟩
Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0131c772c92189bcb23ca565b10e831e
https://cronfa.swan.ac.uk/Record/cronfa53171
https://cronfa.swan.ac.uk/Record/cronfa53171
Autor:
Uttamkumar Samanta, Manal A. Swairjo, Jonathan Alvarez, Dirk Iwata-Reuyl, Adriana Bon Ramos, Xianghan Mei
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 85:103-116
The tunneling-fold (T-fold) structural superfamily has emerged as a versatile protein scaffold of diverse catalytic activities. This is especially evident in the pathways to the 7-deazaguanosine modified nucleosides of tRNA queuosine and archaeosine.