The role of Toll-like receptor 9 and ammonia in the development of hepatic encephalopathy, brain oedema and immune dysfunction

Autor: Manakkat Vijay, Godhev Kumar

Ammonia plays a central role in the pathogenesis of cerebral oedema in paracetamol-induced acute liver failure (PALF). Infection and inflammation play an important synergistic role in its development. Toll-like receptors (TLRs) sense pathogens and in

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.718535

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9

Autor: Manakkat Vijay, Godhev Kumar, Hu, Changyun, Peng, Jian, Garcia-Martinez, Irma, Hoque, Rafaz, Verghis, Rejina Mariam, Ma, Yun, Mehal, Wajahat Zafar, Shawcross, Debbie Lindsay, Wen, Li

Publikováno v: In Cellular and Molecular Gastroenterology and Hepatology 2019 8(4):609-623

Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial.

Autor: Patel, Vishal C.^1,2,3 (AUTHOR), Lee, Sunjae^1,4,5,6 (AUTHOR), McPhail, Mark J.W.^1,2,7 (AUTHOR), Da Silva, Kevin⁸ (AUTHOR), Guilly, Susie⁸ (AUTHOR), Zamalloa, Ane¹ (AUTHOR), Witherden, Elizabeth⁴ (AUTHOR), Støy, Sidsel⁹ (AUTHOR), Manakkat Vijay, Godhev Kumar² (AUTHOR), Pons, Nicolas⁸ (AUTHOR), Galleron, Nathalie⁸ (AUTHOR), Huang, Xaiohong² (AUTHOR), Gencer, Selin⁷ (AUTHOR), Coen, Muireann⁷ (AUTHOR), Tranah, Thomas Henry^1,2 (AUTHOR), Wendon, Julia Alexis^1,2 (AUTHOR), Bruce, Kenneth D.¹⁰ (AUTHOR), Le Chatelier, Emmanuelle⁸ (AUTHOR), Ehrlich, Stanislav Dusko⁸ (AUTHOR), Edwards, Lindsey Ann² (AUTHOR)

Publikováno v: Journal of Hepatology. Feb2022, Vol. 76 Issue 2, p332-342. 11p.