Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Manabu Toyoshima"'
Autor:
Tomonori Hara, Manabu Toyoshima, Yasuko Hisano, Shabeesh Balan, Yoshimi Iwayama, Harumi Aono, Yushi Futamura, Hiroyuki Osada, Yuji Owada, Takeo Yoshikawa
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Carbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1, the gene encoding
Externí odkaz:
https://doaj.org/article/a5cc49e3b8d54d4a818d9847431f0860
Autor:
Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 432-446 (2019)
Background: Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients. We aimed to test the role of betaine in schizophrenia pathophysiology, and to evaluate its potential as a
Externí odkaz:
https://doaj.org/article/8e044d4f4b674d4db13d08c405718559
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport
Autor:
Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Akiyoshi Kakita, Manabu Toyoshima, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108971- (2021)
Summary: In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but the related molecular mechanism remains largely elusive. Using Kif3b+/− mice as a model with SCZ-like behaviors, we found that a high-betaine die
Externí odkaz:
https://doaj.org/article/4c9b7e9f217844439440e312b6372119
Autor:
Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima‐Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto‐Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Genomic defects with large effect size can help elucidate unknown pathologic architecture of mental disorders. We previously reported on a patient with schizophrenia and a balanced translocation between chromosomes 4 and 13 and found that th
Externí odkaz:
https://doaj.org/article/c3d643b8363c4222821faa0e5c5dffd8
VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction
Autor:
Noriyoshi Usui, Keiko Iwata, Taishi Miyachi, Shu Takagai, Keisuke Wakusawa, Takahiro Nara, Kenji J. Tsuchiya, Kaori Matsumoto, Daisuke Kurita, Yosuke Kameno, Tomoyasu Wakuda, Kiyokazu Takebayashi, Yasuhide Iwata, Toru Fujioka, Takaharu Hirai, Manabu Toyoshima, Tetsuo Ohnishi, Tomoko Toyota, Motoko Maekawa, Takeo Yoshikawa, Masato Maekawa, Kazuhiko Nakamura, Masatsugu Tsujii, Toshiro Sugiyama, Norio Mori, Hideo Matsuzaki
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102917- (2020)
Background: Abnormalities of lipid metabolism contributing to the autism spectrum disorder (ASD) pathogenesis have been suggested, but the mechanisms are not fully understood. We aimed to characterize the lipid metabolism in ASD and to explore a biom
Externí odkaz:
https://doaj.org/article/aecdbe3a4a7d484094a99cf824b2f652
Autor:
Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto‐Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
Abstract Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as‐yet‐unknown pathophysiologies of schizophrenia, we undertook proteom
Externí odkaz:
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4
Publikováno v:
Neurobiology of Disease, Vol 131, Iss , Pp - (2019)
Schizophrenia is one of the leading causes of disability among mental disorders, contributing to a substantial socioeconomic burden. Our understanding of the mechanisms of the pathogenesis of the disease has largely been limited by its inherent compl
Externí odkaz:
https://doaj.org/article/22151d5580984c758c976379785ac797
Autor:
Takuya Matsumoto, Koki Fujimori, Tomoko Andoh-Noda, Takayuki Ando, Naoko Kuzumaki, Manabu Toyoshima, Hirobumi Tada, Kent Imaizumi, Mitsuru Ishikawa, Ryo Yamaguchi, Miho Isoda, Zhi Zhou, Shigeto Sato, Tetsuro Kobayashi, Manami Ohtaka, Ken Nishimura, Hiroshi Kurosawa, Takeo Yoshikawa, Takuya Takahashi, Mahito Nakanishi, Manabu Ohyama, Nobutaka Hattori, Wado Akamatsu, Hideyuki Okano
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 422-435 (2016)
Modeling of neurological diseases using induced pluripotent stem cells (iPSCs) derived from the somatic cells of patients has provided a means of elucidating pathogenic mechanisms and performing drug screening. T cells are an ideal source of patient-
Externí odkaz:
https://doaj.org/article/e6518bb7a49f4ff8af3ffc8d2cad638b
Autor:
Shabeesh Balan, Kazuo Yamada, Eiji Hattori, Yoshimi Iwayama, Tomoko Toyota, Tetsuo Ohnishi, Motoko Maekawa, Manabu Toyoshima, Yasuhide Iwata, Katsuaki Suzuki, Mitsuru Kikuchi, Takeo Yoshikawa
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70302 (2013)
The post-synaptic density (PSD) of glutamatergic synapses harbors a multitude of proteins critical for maintaining synaptic dynamics. Alteration of protein expression levels in this matrix is a marked phenomenon of neuropsychiatric disorders includin
Externí odkaz:
https://doaj.org/article/092fe5d8d0924639bf4e32abb9d6f48b
Publikováno v:
Bulletin of Earthquake Engineering. 21:2759-2783
Large-span steel structures have been widely adopted in stadiums, airports, factories, and train stations because they provide a large space for multi-functional use. To ensure business continuity, post-earthquake damage surveys and structural status