Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Manabu Nagao"'
Autor:
Takuya Iino, Manabu Nagao, Hidekazu Tanaka, Sachiko Yoshikawa, Junko Asakura, Makoto Nishimori, Masakazu Shinohara, Amane Harada, Shunsuke Watanabe, Tatsuro Ishida, Ken-ichi Hirata, Ryuji Toh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The pathophysiology of variant transthyretin (TTR) amyloidosis (ATTRv) is associated with destabilizing mutations in the TTR tetramer. However, why TTR with a wild-type genetic sequence misfolds and aggregates in wild-type transthyretin amyl
Externí odkaz:
https://doaj.org/article/0649b95f344746439c3c1bbcebaf3940
Autor:
Susumu Odajima, Wataru Fujimoto, Misa Takegami, Kunihiro Nishimura, Masamichi Iwasaki, Masanori Okuda, Akihide Konishi, Masakazu Shinohara, Manabu Nagao, Ryuji Toh, Ken‐ichi Hirata, Hidekazu Tanaka
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)
Background Stage B heart failure (HF) refers to structural heart disease without signs or symptoms of HF, so that early intervention may delay or prevent the onset of overt HF. However, stage B HF is a very broad concept, and risk stratification of s
Externí odkaz:
https://doaj.org/article/0039c0bd0d924d0283f51dc018d9384a
Autor:
Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Junko Asakura, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Stress has garnered significant attention as a prominent risk factor for inflammation-related diseases, particularly cardiovascular diseases (CVDs). However, the precise mechanisms underlying stress-driven CVDs remain elusive, thereby impedi
Externí odkaz:
https://doaj.org/article/87b82116fc46422dbb4882fe053c3956
Autor:
Katsuhiro Murakami, Amane Harada, Ryuji Toh, Takuya Kubo, Keiko Miwa, Jeeeun Kim, Maria Kiriyama, Takuya Iino, Youichi Nishikawa, Shin-Nosuke Uno, Kohei Akatsuchi, Manabu Nagao, Tatsuro Ishida, Ken-ichi Hirata
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract High-density lipoprotein (HDL) cholesterol efflux capacity (CEC), which is a conventional metric of HDL function, has been associated with coronary heart disease risk. However, the CEC assay requires cultured cells and takes several days to
Externí odkaz:
https://doaj.org/article/1de9aa4def1445c6b15847a2a21ee1b1
Autor:
Wataru Fujimoto, Ryuji Toh, Misa Takegami, Junichi Imanishi, Tomoyo Hamana, Susumu Odajima, Makoto Takemoto, Koji Kuroda, Yutaka Hatani, Soichiro Yamashita, Masamichi Iwasaki, Takumi Inoue, Hiroshi Okamoto, Takafumi Todoroki, Masanori Okuda, Takatoshi Hayashi, Akihide Konishi, Hidekazu Tanaka, Masakazu Shinohara, Manabu Nagao, Shunsuke Murata, Soshiro Ogata, Kunihiro Nishimura, Ken‐ichi Hirata
Publikováno v:
ESC Heart Failure, Vol 10, Iss 1, Pp 100-110 (2023)
Abstract Aims With the rapidly increasing ageing population, heart failure is an urgent challenge, particularly in developed countries. The study aimed to investigate the main aetiologies of chronic heart failure in a super‐aged society. Methods an
Externí odkaz:
https://doaj.org/article/7c9beb0c798842918115e1af9774a23c
Autor:
Quanyi Zhao, Robert Wirka, Trieu Nguyen, Manabu Nagao, Paul Cheng, Clint L. Miller, Juyong Brian Kim, Milos Pjanic, Thomas Quertermous
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of t
Externí odkaz:
https://doaj.org/article/3b459120b9da42e798da9ee5490cdb9e
Autor:
Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract High-density lipoprotein (HDL) interacts with various cells, particularly macrophages, in functional cell-HDL interactions. Here, we found that HDL protein quality and lipid quality play critical roles in HDL functions. HDL fractions from he
Externí odkaz:
https://doaj.org/article/3b7d6c0118994f47908cc9a7e8a96bc3
Autor:
Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Hideto Nakajima, Toshihiko Oshita, Shigeyasu Tsuda, Tetsuya Hara, Masakazu Shinohara, Tatsuro Ishida, Ken‐ichi Hirata
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1402-1409 (2017)
Low levels of plasma high‐density lipoprotein (HDL) cholesterol are associated with an increased risk of heart failure, regardless of the presence or absence of coronary artery disease. However, the direct effects of HDL on failing myocardium have
Externí odkaz:
https://doaj.org/article/3289ada030db4e5c940b3247e80ecb3a
Autor:
Dharini Iyer, Quanyi Zhao, Robert Wirka, Ameay Naravane, Trieu Nguyen, Boxiang Liu, Manabu Nagao, Paul Cheng, Clint L Miller, Juyong Brian Kim, Milos Pjanic, Thomas Quertermous
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007681 (2018)
Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studi
Externí odkaz:
https://doaj.org/article/99defefc362444aba60b5af133ec8f9c
Autor:
Susumu Odajima, Wataru Fujimoto, Misa Takegami, Kunihiro Nishimura, Masamichi Iwasaki, Masanori Okuda, Akihide Konishi, Masakazu Shinohara, Manabu Nagao, Ryuji Toh, Ken-Ichi Hirata, Hidekazu Tanaka
Publikováno v:
Journal of the American Heart Association; 10/1/2024, Vol. 13 Issue 19, p1-11, 11p