Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Manabu Mukai"'
Autor:
Yukie Metoki, Dai Iwase, Yasuaki Kusumoto, Jun Aikawa, Manabu Mukai, Kensuke Fukushima, Gen Inoue, Masashi Takaso
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background Suction drainages are commonly used after total knee arthroplasty (TKA) procedures; however, their use is somewhat controversial. Recently, some reports have claimed that the administration of tranexamic acid (TXA) may prevent pos
Externí odkaz:
https://doaj.org/article/87e118b8471d455e899cd84eae2af23f
Autor:
Naoya Shibata, Yoshihisa Ohashi, Ayumi Tsukada, Dai Iwase, Jun Aikawa, Manabu Mukai, Yukie Metoki, Yui Uekusa, Masashi Sato, Gen Inoue, Masashi Takaso, Kentaro Uchida
Publikováno v:
Medicina, Vol 60, Iss 5, p 741 (2024)
(1) Introduction: Despite documented clinical and pain discrepancies between male and female osteoarthritis (OA) patients, the underlying mechanisms remain unclear. Synovial myofibroblasts, implicated in synovial fibrosis and OA-related pain, offer a
Externí odkaz:
https://doaj.org/article/89c82e69c6c14119b1f60eec004eac45
Autor:
Ayumi Tsukada, Ken Takata, Jun Aikawa, Dai Iwase, Manabu Mukai, Yui Uekusa, Yukie Metoki, Gen Inoue, Masayuki Miyagi, Masashi Takaso, Kentaro Uchida
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 877 (2024)
Diabetes mellitus (DM) has been suggested as a potential risk factor for knee osteoarthritis (KOA), and its underlying mechanisms remain unclear. The infrapatellar fat pad (IPFP) contributes to OA through inflammatory mediator secretion. Mast cells
Externí odkaz:
https://doaj.org/article/9ac11c848c7f44c9abcc9f9513906c91
Autor:
Maho Tsuchiya, Yoshihisa Ohashi, Yoshio Kodera, Masashi Satoh, Takashi Matsui, Kensuke Fukushima, Dai Iwase, Jun Aikawa, Manabu Mukai, Gen Inoue, Masashi Takaso, Kentaro Uchida
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3047 (2023)
Recent studies utilizing single-cell analysis have unveiled the presence of various fibroblast (Fb) subsets within the synovium under inflammatory conditions in osteoarthritis (OA), distinguishing them from those in rheumatoid arthritis (RA). Moreove
Externí odkaz:
https://doaj.org/article/14985672141845a4bcea60fb6cc3694a
Autor:
Dai Iwase, Yukie Metoki, Yasuaki Kusumoto, Jun Aikawa, Kensuke Fukushima, Shotaro Takano, Manabu Mukai, Kentaro Uchida, Gen Inoue, Masashi Takaso
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background In primary total knee arthroplasty (TKA), tibial bone defects ≥ 10 mm in depth often become uncontained defects, a condition most surgeons find challenging to treat. Although the allogenous bone graft is a useful method, complic
Externí odkaz:
https://doaj.org/article/8fef6d10a0524ae485447e94214a073f
Autor:
Ken Takata, Shotaro Takano, Masayuki Miyagi, Manabu Mukai, Dai Iwase, Jun Aikawa, Yoshihisa Ohashi, Gen Inoue, Masashi Takaso, Kentaro Uchida
Publikováno v:
Central European Journal of Immunology, Vol 46, Iss 4, Pp 470-473 (2021)
Rheumatoid arthritis (RA), a systemic autoimmune disease, is known to cause chronic inflammation in synovial joints. A number of inflammatory conditions are associated with stimulation of Clec4e, a macrophage-inducible C-type lectin (MINCLE) and tran
Externí odkaz:
https://doaj.org/article/273c72ac7f854250b56ee3619a54dea1
Autor:
Shintaro Shoji, Kentaro Uchida, Gen Inoue, Ken Takata, Manabu Mukai, Jun Aikawa, Dai Iwase, Shotaro Takano, Hiroyuki Sekiguchi, Masashi Takaso
Publikováno v:
Central European Journal of Immunology, Vol 46, Iss 2, Pp 231-235 (2021)
Externí odkaz:
https://doaj.org/article/991df4e11afd4e85bba1d28b16b2f472
Autor:
Ayumi Tsukada, Kentaro Uchida, Jun Aikawa, Shotaro Takano, Dai Iwase, Manabu Mukai, Masayuki Miyagi, Yuta Nanri, Gen Inoue, Masashi Takaso
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-7 (2020)
Abstract Background Muscle weakness is associated with osteoarthritis pathology. A recent study demonstrated that measuring muscle volume using computed tomography (CT)-based analysis and comparing bilateral muscles in the same patient allowed for ac
Externí odkaz:
https://doaj.org/article/45065be6656043e0ac7c1d60da512bdb
Autor:
Ayumi Tsukada, Ken Takata, Shotaro Takano, Yoshihisa Ohashi, Manabu Mukai, Jun Aikawa, Dai Iwase, Gen Inoue, Masashi Takaso, Kentaro Uchida
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11237 (2022)
Obesity is a risk factor for knee osteoarthritis (KOA). Neuromedin U (NMU) and NMU receptors (NMUR1 and NMUR2) are associated with obesity-related disorders and found in mast cells (MCs), which are elevated in osteoarthritis. However, NMU/NMUR expres
Externí odkaz:
https://doaj.org/article/0ff7060264cd482d9b69a2a773f11d9f
Autor:
Manabu Mukai, Kentaro Uchida, Tadashi Okubo, Shotaro Takano, Toshihide Matsumoto, Masashi Satoh, Gen Inoue, Masashi Takaso
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Bone marrow-derived monocytes/macrophages are recruited into synovial tissue, where they contribute to synovial inflammation in osteoarthritis through inflammatory cytokine production. Recent studies have suggested that V-Set and transmem
Externí odkaz:
https://doaj.org/article/fe716f1c056f4c3a82cdb7cbf891669b