Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Manabu Ishiki"'
1
Akademický článek
Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients
Autor: Minoru Iwata, Yutaka Kamura, Hisae Honoki, Kaori Kobayashi, Manabu Ishiki, Kunimasa Yagi, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuhito Fukuda, Yukiko Koshimizu, Kazuyuki Tobe
Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 3, Pp 564-572 (2020)
Abstract Aims/Introduction The objective of the present study was to clarify the association of the type and number of first‐degree family history of diabetes (FHD) with the clinical characteristics, especially with residual β‐cell function, in
Externí odkaz: https://doaj.org/article/a1720d67a2264891be24049d604b4eaf
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2
Akademický článek
Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
Autor: Minoru Iwata, Kazuo Hara, Yutaka Kamura, Hisae Honoki, Shiho Fujisaka, Manabu Ishiki, Isao Usui, Kunimasa Yagi, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuhito Fukuda, Yukiko Koshimizu, Kazuyuki Tobe
Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0192609 (2018)
Among the three adiponectin isoforms, a lower ratio of high molecular weight (HMW) adiponectin to total adiponectin (TA) is well known to cause insulin resistance and type 2 diabetes (T2D). However, how the levels of other adiponectin isoforms, such
Externí odkaz: https://doaj.org/article/4a48fa4938c246759ae6aeb1ba5d4cec
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3
Akademický článek
FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.
Autor: Yutaka Kamura, Minoru Iwata, Shiro Maeda, Satomi Shinmura, Yukiko Koshimizu, Hisae Honoki, Kazuhito Fukuda, Manabu Ishiki, Isao Usui, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuyuki Tobe
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165523 (2016)
Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass incr
Externí odkaz: https://doaj.org/article/41077e01667841539abdaeaf332fe035
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4
Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients
Autor: Kazuhito Fukuda, Hisae Honoki, Yukiko Koshimizu, Yasuo Fukushima, Kiyohiro Higuchi, Kaori Kobayashi, Shihou Murakami, Yutaka Kamura, Kunimasa Yagi, Manabu Ishiki, Chikaaki Kobashi, Kazuyuki Tobe, Hiromi Kato, Minoru Iwata, Atsuko Takano
Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 3, Pp 564-572 (2020)
Journal of Diabetes Investigation
Aims/Introduction The objective of the present study was to clarify the association of the type and number of first‐degree family history of diabetes (FHD) with the clinical characteristics, especially with residual β‐cell function, in type 2 di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5919f9ad8149ab77302f7f5b943d18
https://doaj.org/article/a1720d67a2264891be24049d604b4eaf
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5
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
Autor: Yuji Matsuya, Masashi Kobayashi, Hikari Suzuki, Satoko Senda, Isao Usui, Agussalim Bukhari, Yukiko Kanatani, Yu Yamazaki, Masaharu Urakaze, Kazuyuki Tobe, Shiho Fujisaka, Ryuji Hayashi, Koichi Tsuneyama, Shingo Imanishi, Hideo Nemoto, Manabu Ishiki, Kazuya Hirata
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 297:E1179-E1186
Nonalcoholic fatty liver disease (NAFLD) is an abnormal liver metabolism often observed with insulin resistance and metabolic syndrome. Calorie restriction is a useful treatment for NAFLD and reportedly prolongs the life spans of several species in w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1929b5c29eaa598a0b327ba67716f30
https://doi.org/10.1152/ajpendo.90997.2008
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6
Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-α-induced insulin resistance in 3T3-L1 adipocytes
Autor: Manabu Ishiki, Hajime Ishihara, Toshiyasu Sasaoka, Mariko Ikubo, Tsutomu Wada, Tomoichiro Asano, Kazuhito Fukui, Hiroshi Tsuneki
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 296:E157-E164
TNF-alpha is a major contributor to the pathogenesis of insulin resistance associated with obesity and inflammation by serine phosphorylating and degrading insulin receptor substrate-1. Presently, we further found that pretreatment with TNF-alpha inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d31586eb223cb40bb2f372891a2ae2
https://doi.org/10.1152/ajpendo.90581.2008
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8
Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
Autor: Hajime Ishihara, Tsutomu Wada, Manabu Ishiki, Masashi Kobayashi, Toshiyasu Sasaoka, Hiroyuki Hori, Shihou Murakami
Publikováno v: Diabetes. 51:2387-2394
SH-2-containing inositol 5′-phosphatase 2 (SHIP-2) is a physiologically important lipid phosphatase that functions to hydrolyze phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adcd7db299eb0aeb0fb797f9343d630
https://doi.org/10.2337/diabetes.51.8.2387
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9
Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells
Autor: Rie Temaru, Isao Usui, Toshiyasu Sasaoka, Masaharu Urakaze, Akira Sato, Masashi Kobayashi, Mika Kishida, Manabu Ishiki, Norio Nakamura, Katsuya Yamazaki, Hajime Ishihara, Tsutomu Wada, Michiyo Takata
Publikováno v: Atherosclerosis. 157:341-352
Vascular smooth muscle cells play a key role in the development of atherosclerosis. Culture of vascular smooth muscle A10 cells with high glucose for 4 weeks enhanced platelet-derived growth factor (PDGF)-induced BrdU incorporation. Since a long peri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f0b8d35471d1e021eb3f8988346612
https://doi.org/10.1016/s0021-9150(00)00740-1
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10
Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity
Autor: Shihou Murakami, Tomoichiro Asano, Tetsuro Haruta, Manabu Ishiki, Hajime Ishihara, Hiroyuki Hori, Masashi Kobayashi, Wataru Ogawa, Tsutomu Wada, Makoto Funaki, Toshiyasu Sasaoka
Publikováno v: Molecular and Cellular Biology. 21:1633-1646
Insulin binding to the extracellular α subunit of the insulin receptor activates the intrinsic tyrosine kinase activity of the intracellular β subunit. The activated insulin receptor phosphorylates the insulin receptor substrate (IRS) family of pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bef98ef490ed86a45eb7fafd7936a7
https://doi.org/10.1128/mcb.21.5.1633-1646.2001
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