Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Manabu Funayama"'
Autor:
Toshiki Tezuka, Mayu Ishiguro, Daisuke Taniguchi, Ehoto Osogaguchi, Kahori Shiba-Fukushima, Jun Ogata, Ryota Ishii, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Taro Matsui, Kenichi Kaida, Manabu Funayama, Kenya Nishioka, Fumihisa Kumazawa, Tomoyasu Matsubara, Hitoshi Tsuda, Yuko Saito, Shigeo Murayama, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106571- (2024)
Leucine-rich repeat kinase 2 (LRRK2) is the most common gene responsible for familial Parkinson's disease (PD). The gene product of LRRK2 contains multiple protein domains, including armadillo repeat, ankyrin repeat, leucine-rich repeat (LRR), Ras-of
Externí odkaz:
https://doaj.org/article/de656de5f6c04063a9a2a899476b1c7d
Autor:
Mayu Ishiguro, Manabu Funayama, Taku Hatano, Hiroshi Nishida, Yuko Wada, Kazuyuki Noda, Masahiko Tomiyama, Hiroyo Yoshino, Yuanzhe Li, Stephanie Ong, Ettore Cioffi, Kenya Nishioka, Nobutaka Hattori
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35271- (2024)
Background: Biallelic variants in PARK7, which encodes protein-nucleic acid deglycase DJ-1, can cause early-onset Parkinson's disease (PD). Although many patients with PARK7 variants have been identified from European and Middle Eastern ethnic groups
Externí odkaz:
https://doaj.org/article/30fc1bb21b564f41b30e176752e1c380
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103270- (2024)
The appropriate control of induced pluripotent stem cells (iPSCs) is essential for studying iPSCs derived from patients with Parkinson’s disease (PD). Here, we established an iPSC line from a healthy female donor. The iPSCs were pluripotent, could
Externí odkaz:
https://doaj.org/article/8b2fc3b9e2ff422192bdeccafc8c0b98
Autor:
Toshiki Tezuka, Daisuke Taniguchi, Mariko Sano, Tomoyo Shimada, Yutaka Oji, Taiji Tsunemi, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Jun Ogata, Kahori Shiba-Fukushima, Manabu Funayama, Kenya Nishioka, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic Parkinson’s disease (PD). The pathological features of PD patients with LRRK2 variants differ. Here, we report an autopsy case harboring the LRRK2 G238
Externí odkaz:
https://doaj.org/article/f5424e9f60a54fa681ba5d764347fb97
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Over the past 20 years, numerous robust analyses have identified over 20 genes related to familial Parkinson's disease (PD), thereby uncovering its molecular underpinnings and giving rise to more sophisticated approaches to investigate its pathogenes
Externí odkaz:
https://doaj.org/article/c21713e5f82040e78bd957bd251a3dc7
Autor:
Kensuke Daida, Yosuke Nishioka, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Nobutaka Hattori, Kenya Nishioka
Publikováno v:
eNeurologicalSci, Vol 26, Iss , Pp 100391- (2022)
Individuals with hereditary spastic paraplegia (HSP) are known to present with a variety of symptoms, including intellectual disability, cognitive decline, parkinsonism, and epilepsy. We report here our experience of treating a family with consanguin
Externí odkaz:
https://doaj.org/article/0b11aa0414894d12addc4b6c2416b9cd
Autor:
Kensuke Daida, Manabu Funayama, Yuanzhe Li, Hiroyo Yoshino, Arisa Hayashida, Aya Ikeda, Kotaro Ogaki, Kenya Nishioka, Nobutaka Hattori
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Recent advanced technologies, such as high-throughput sequencing, have enabled the identification of a broad spectrum of variants. Using targeted-gene-panel resequencing for Parkinson's disease (PD)-associated genes, we have occasionally
Externí odkaz:
https://doaj.org/article/4dd44d45098b4e0fa8f86b0910686559
Autor:
Masashi Takanashi, Manabu Funayama, Eiji Matsuura, Hiroyo Yoshino, Yuanzhe Li, Sho Tsuyama, Hiroshi Takashima, Kenya Nishioka, Nobutaka Hattori
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Leucine-rich repeat kinase 2 (LRRK2) is the most common causative gene for autosomal dominant Parkinson’s disease (PD) and is also known to be a susceptibility gene for sporadic PD. Although clinical symptoms with LRRK2 mutations are simil
Externí odkaz:
https://doaj.org/article/be42c46e4f794e1481bc27e60180c9d5
Autor:
Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing c
Externí odkaz:
https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f
Autor:
Yukiko Usami, Taku Hatano, Satoshi Imai, Shin-ichiro Kubo, Shigeto Sato, Shinji Saiki, Yoichiro Fujioka, Yusuke Ohba, Fumiaki Sato, Manabu Funayama, Hiroto Eguchi, Kaori Shiba, Hiroyoshi Ariga, Jie Shen, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 651-662 (2011)
Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons. Although many reports have suggested that genetic factors are implicated in the pathogenesis of PD, molecular mechanisms underlying selective dopaminergi
Externí odkaz:
https://doaj.org/article/92d135c3d8e246439bc1a795efc8dce3