Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Manabu Fujisawa"'
Autor:
Yasuhito Suehara, Kana Sakamoto, Manabu Fujisawa, Kota Fukumoto, Yoshiaki Abe, Kenichi Makishima, Sakurako Suma, Takeshi Sugio, Koji Kato, Koichi Akashi, Kosei Matsue, Kentaro Narita, Kengo Takeuchi, Naoya Nakamura, Seishi Ogawa, Shigeru Chiba, Mamiko Sakata-Yanagimoto
Publikováno v:
HemaSphere, Vol 7, p e1725993 (2023)
Externí odkaz:
https://doaj.org/article/c93edcfb0ef34838bf86d8b68d916947
Autor:
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
Publikováno v:
Circulation. 147:223-238
Background: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. Therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80af7a88c628ac7efe59fd4b41f663fb
https://doi.org/10.1161/circulationaha.121.058655
https://doi.org/10.1161/circulationaha.121.058655
Autor:
Shigeru Chiba, Koichi Ohshima, Seishi Ogawa, Shintaro Yanagimoto, Manabu Kusakabe, Naoshi Obara, Hidekazu Nishikii, Yuji Sato, Takuya Suyama, Atsushi Shinagawa, Shinichiro Sukegawa, Haruka Momose, Kantaro Ishitsuka, Yusuke Kiyoki, Olivier A. Bernard, Kota Fukumoto, Koichi Hashimoto, Yasuhito Nannya, Hiroaki Miyoshi, Sharna Tanzima Nuhat, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Tran B. Nguyen
Supplemental methods, results, figures, and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c815463888ba17b5a827e7ef168711af
https://doi.org/10.1158/0008-5472.22424491
https://doi.org/10.1158/0008-5472.22424491
Autor:
Shigeru Chiba, Koichi Ohshima, Seishi Ogawa, Shintaro Yanagimoto, Manabu Kusakabe, Naoshi Obara, Hidekazu Nishikii, Yuji Sato, Takuya Suyama, Atsushi Shinagawa, Shinichiro Sukegawa, Haruka Momose, Kantaro Ishitsuka, Yusuke Kiyoki, Olivier A. Bernard, Kota Fukumoto, Koichi Hashimoto, Yasuhito Nannya, Hiroaki Miyoshi, Sharna Tanzima Nuhat, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Tran B. Nguyen
Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function mutations in TET2 encoding an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b657c26606172804a23dac008ee99a48
https://doi.org/10.1158/0008-5472.c.6511786.v1
https://doi.org/10.1158/0008-5472.c.6511786.v1
Autor:
Yoshiaki Abe, Mamiko Sakata-Yanagimoto, Manabu Fujisawa, Hiroaki Miyoshi, Yasuhito Suehara, Keiichiro Hattori, Manabu Kusakabe, Tatsuhiro Sakamoto, Hidekazu Nishikii, Tran B. Nguyen, Yohei Owada, Tsuyoshi Enomoto, Aya Sawa, Hiroko Bando, Chikashi Yoshida, Rikako Tabata, Toshiki Terao, Masahiro Nakayama, Koichi Ohshima, Kensuke Usuki, Tatsuya Oda, Kosei Matsue, Shigeru Chiba
Publikováno v:
Nature Cell Biology. 24:565-578
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our understanding of lymphoma NHCs has been hampered by unexplained NHC hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b85a5b9bcb3b5e4fcb2cc009fb23f6f
https://doi.org/10.1038/s41556-022-00866-3
https://doi.org/10.1038/s41556-022-00866-3
Autor:
Manabu Fujisawa, Tran B. Nguyen, Yoshiaki Abe, Yasuhito Suehara, Kota Fukumoto, Sakurako Suma, Kenichi Makishima, Chihiro Kaneko, Yen T.M. Nguyen, Kensuke Usuki, Kentaro Narita, Kosei Matsue, Naoya Nakamura, Shumpei Ishikawa, Fumihito Miura, Takashi Ito, Ayako Suzuki, Yutaka Suzuki, Seiya Mizuno, Satoru Takahashi, Shigeru Chiba, Mamiko Sakata-Yanagimoto
Publikováno v:
Blood. 140(18)
Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes the development of T follicular helper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89f4509b83820de6590acccf34ee9ea
https://pubmed.ncbi.nlm.nih.gov/36326793
https://pubmed.ncbi.nlm.nih.gov/36326793
Single-Cell Transcriptome Reveals Comprehensive Immune Profiles of T Follicular Helper Cell Lymphoma
Autor:
Sakurako Suma, Manabu Fujisawa, Yoshiaki Abe, Yasuhito Suehara, Daisuke Kaji, Takeshi Sugio, Koji Kato, Koichi Akashi, Kosei Matsue, Naoya Nakamura, Ayako Suzuki, Yutaka Suzuki, Shigeru Chiba, Mamiko Sakata-Yanagimoto
Publikováno v:
Blood. 140:8754-8755
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d487efb98a27f9c4cb283c732104f27c
https://doi.org/10.1182/blood-2022-159804
https://doi.org/10.1182/blood-2022-159804
Autor:
Haruka Momose, Kota Fukumoto, Shigeru Chiba, Hiroaki Miyoshi, Olivier A. Bernard, Hidekazu Nishikii, Yuji Sato, Shinichiro Sukegawa, Mamiko Sakata-Yanagimoto, Sharna Tanzima Nuhat, Koichi Hashimoto, Yusuke Kiyoki, Kantaro Ishitsuka, Naoshi Obara, Tran B. Nguyen, Shintaro Yanagimoto, Takuya Suyama, Yasuhito Nannya, Manabu Kusakabe, Koichi Ohshima, Atsushi Shinagawa, Manabu Fujisawa, Seishi Ogawa
Publikováno v:
Cancer Research. 80:1875-1884
Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function mutations in TET2 encoding an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d1e88e9de4562e16808b9bc8ae1b2e
https://doi.org/10.1158/0008-5472.can-19-2787
https://doi.org/10.1158/0008-5472.can-19-2787
Autor:
Manabu Fujisawa, Yasuhito Suehara, Shigeru Chiba, Kota Fukumoto, Masayuki Noguchi, Ryota Matsuoka, Mamiko Sakata-Yanagimoto, Yen T. M. Nguyen, Daisuke Matsubara, Keiichiro Hattori, Tran B. Nguyen, Yoshiaki Abe, Tatsuhiro Sakamoto
Publikováno v:
Cancer Science
Immune cells harboring somatic mutations reportedly infiltrate cancer tissues in patients with solid cancers and accompanying clonal hematopoiesis. Loss‐of‐function TET2 mutations are frequently observed in clonal hematopoiesis in solid cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834f1154b1e73da23036c9a624c7dcec
https://pubmed.ncbi.nlm.nih.gov/34657351
https://pubmed.ncbi.nlm.nih.gov/34657351
Autor:
Sakurako Suma, Yasuhito Suehara, Yuichi Shiraishi, Kouichi Ohshima, Alyssa Bouska, Javeed Iqbal, Tatsuhiro Sakamoto, Tran B. Nguyen, Shintaro Yanagimoto, Kenichi Chiba, Mamiko Sakata-Yanagimoto, Seishi Ogawa, Shigeru Chiba, Hiroaki Miyoshi, Manabu Fujisawa, Kota Fukumoto, Keisuke Kataoka
Publikováno v:
Blood
Activating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCN). However, oncogenic activities associated with VAV1 mutations in TCN remain unclear. To define them, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e17854d932921bc725c63d9e3ef0f9
https://pubmed.ncbi.nlm.nih.gov/32992343
https://pubmed.ncbi.nlm.nih.gov/32992343