Výsledky vyhledávání - "Manabu Chokki"

TEI-A00114: A new vitamin D3 analogue that inhibits neutrophil recruitment in an acute lung injury hamster model while showing reduced hypercalcemic activity

Autor: Qingzhi Gao, Koichi Ueno, Hiroko Tanaka, Seiichi Ishizuka, Minoru Furuya, Yasuhiro Takano, Katsushi Takahashi, Kenji Manabe, Masayasu Tabe, Atsushi Hazato, Kazuya Takenouchi, Hiroaki Mitsuhashi, Manabu Chokki

Publikováno v: Steroids. 77:1535-1542

While searching for vitamin D(3) analogues which inhibit neutrophil recruitment in the lung without elevating plasma calcium level, we found that (5Z,7E)-(1S,3R)-20(R)-[(5E)-(2S)-2-hydroxy-2-methyl-cyclopentanone-5-ylidene]methyl-9,10-secopregna-5,7,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6358fc5b6ab645347f81d438d7e3a
https://doi.org/10.1016/j.steroids.2012.09.008

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Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-α-induced IL-8 secretion in the human airway epithelial cell line NCI-H292

Autor: Manabu Chokki, Takashi Kamimura, Hiroaki Mitsuhashi

Publikováno v: Life Sciences. 78:3051-3057

Tumor necrosis factor-alpha (TNF-alpha) is a potent multifunctional cytokine that plays a central role in the pathogenesis of many inflammatory diseases. Interleukin-8 (IL-8) is a principle neutrophil chemoattractant and activator in humans. The alve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f415cd98fd311b666918039b382f9fd
https://doi.org/10.1016/j.lfs.2005.12.023

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Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells

Autor: Ichiro Hamamura, Hiroshi Eguchi, Hiroaki Mitsuhashi, Takashi Kamimura, Manabu Chokki

Publikováno v: FEBS Journal. 272:6387-6399

Human airway trypsin-like protease (HAT), a serine protease found in the sputum of patients with chronic airway diseases, is an agonist of protease-activated receptor-2 (PAR-2). Previous results have shown that HAT enhances the release of amphireguli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e1ebfea34b7c014662724ab3e4f1c2
https://doi.org/10.1111/j.1742-4658.2005.05035.x

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Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1α,25-dihydroxyvitamin D3 and 20-epi-2-methyl-1α,25-dihydroxyvitamin D3

Autor: Katsuhiro Konno, Hector F. DeLuca, Mayuko Kurobe, Shojiro Maki, Toshio Okano, Toshie Fujishima, Kimie Nakagawa, Connie M. Smith, Zhaopeng Liu, Daishiro Miura, Manabu Chokki, Hiroaki Takayama, Seiichi Ishizuka

Publikováno v: Steroids. 66:277-285

All possible A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2) and 20-epi-2-methyl-1alpha,25-dihydroxyvitamin D(3) (3) were synthesized by palladium-catalyzed coupling reaction of A-ring 'enyne' synthons with CD-ring portions. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48360a76d2fc1391ab7639e3102c1112
https://doi.org/10.1016/s0039-128x(00)00141-0

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Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3 and Their 20-Epimers: Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20

Autor: Hiroaki Takayama, Shojiro Maki, N. Miyata, Manabu Chokki, Seiichi Ishizuka, Connie Smith, Yukiko Kan, Masaaki Kurihara, Hector F. Deluca, Toshie Fujishima, Zhaopeng Liu, Daishiro Miura, Kentaro Yamaguchi, Katsuhiro Konno

Publikováno v: Journal of Medicinal Chemistry. 43:4247-4265

All eight possible A-ring diastereomers of 2-methyl-1, 25-dihydroxyvitamin D(3) (2) and 2-methyl-20-epi-1, 25-dihydroxyvitamin D(3) (3) were convergently synthesized. The A-ring enyne synthons 19 were synthesized starting with methyl (S)-(+)- or (R)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32b9f8ee79610de3082f92b01eb551f
https://doi.org/10.1021/jm000261j

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Antagonistic Action of Novel 1α,25-Dihydroxyvitamin D3-26,23-Lactone Analogs on 25-Hydroxyvitamin-D3-24-hydroxylase Gene Expression Induced by 1α,25-Dihydroxy-vitamin D3 in Human Promyelocytic Leukemia (HL-60) Cells

Autor: Seiichi Ishizuka, Takashi Kamimura, Daishiro Miura, Manabu Chokki, Keiichi Ozono, Anthony W. Norman, Hiroshi Eguchi

Publikováno v: Archives of Biochemistry and Biophysics. 380:92-102

We have demonstrated that 1alpha,25-dihydroxyvitamin D(3)-26, 23-lactone analogs, (23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647, TEI-9648, respectively), inhibit HL-60 cell differentiation induced by 1alpha,25-dihydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e7f5cd73cbb2232a51fef83b20300f
https://doi.org/10.1006/abbi.2000.1902

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A novel and practical route to A-ring enyne synthon for 1α,25-dihydroxyvitamin D3 analogs: Synthesis of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and 2-methyl-1,25-dihydroxyvitamin D3

Autor: Daishiro Miura, Zhaopeng Liu, Shojiro Maki, Toshie Fujishima, Hiroaki Takayama, Manabu Chokki, Katsuhiro Konno

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:151-156

A novel and practical route to the A-ring enyne synthon (2), which can be versatile for a variety of A-ring analogs of 1α,25-dihydroxyvitamin D3 (1), was developed. This novel method led to an improved synthesis of the A-ring diastereomers of 1, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df9a7e7587e81ea11ab2432c0d902092
https://doi.org/10.1016/s0960-894x(97)10204-9

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ChemInform Abstract: Synthesis and Biological Activity of 2-Methyl-20-epi Analogues of 1α,25-Dihydroxyvitamin D3

Autor: Seiichi Ishizuka, Hiroaki Takayama, Daishiro Miura, Manabu Chokki, Katsuhiro Konno, Toshie Fujishima, Zhaopeng Liu

Publikováno v: ChemInform. 29

Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ea874f3f93221a534cbe4e87efdfd4c
https://doi.org/10.1002/chin.199851275

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Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis

Autor: Takuro Machida, Tetsuji Takayama, Tsutomu Sato, Yasushi Sato, Takuya Matsunaga, Kageaki Kuribayashi, Satoshi Iyama, Masaya Kida, Junji Kato, Manabu Chokki, Kazuhiro Morii, Minoru Takahashi, Kiminori Nakamura, Yutaka Kawano, Kohichi Takada, Yoshiro Niitsu

Publikováno v: American journal of hematology. 77(1)

We came across a rare case of acute megakaryocytic leukemia, the clinical course of which was relatively chronic and nonaggressive. This case was complicated with generalized severe osteosclerosis (OS). The medium in which blastic cells from the pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8989ad0aaab083430ce8b893b7599ed6
https://pubmed.ncbi.nlm.nih.gov/15307108

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