Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Manabu, KUROKAWA"'
Autor:
William W. Feng, Scott Bang, Eric M. Takacs, Cora Day, Katherine J. Crawford, Ruba Al-Sheyab, Dara B. Almufarrej, Wendy Wells, Serguei Ilchenko, Takhar Kasumov, Ning Kon, Colleen M. Novak, Wei Gu, Manabu Kurokawa
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108405- (2023)
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in NAFLD pathogenesis. Using mass spectrometry and RNA sequencing, we reveal that liv
Externí odkaz:
https://doaj.org/article/9d5527d6678e48a18fd4a270775d7fb2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The tumor suppressor p53, encoded by the TP53 gene, is mutated or nullified in nearly 50% of human cancers. It has long been debated whether TP53 mutations can be utilized as a biomarker to predict clinical outcomes of cancer patients. In th
Externí odkaz:
https://doaj.org/article/fd360a5eac7145b4889006fc81ba03bc
Publikováno v:
Cells, Vol 12, Iss 12, p 1605 (2023)
Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain, and ovarian cancers. While it is arguably most well-known for its fatty acid uptake function
Externí odkaz:
https://doaj.org/article/3cc0468439ab4cd38536466cdec907e8
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S1, Pp 25-40 (2021)
Externí odkaz:
https://doaj.org/article/5991cbfa5e3c40488650d18a18028591
Autor:
Sandeep Kaur, Manabu Kurokawa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1345 (2023)
Apoptosis is a form of programmed cell death that plays a critical role in cellular homeostasis and development, including in the ovarian reserve. In humans, hundreds of thousands of oocytes are produced in the fetal ovary. However, the majority die
Externí odkaz:
https://doaj.org/article/41aa3dca56124ac38d5a6ecd3e31d444
Autor:
Alaa A. Eisa, Scott Bang, Katherine J. Crawford, Emily M. Murphy, William W. Feng, Souvik Dey, Wendy Wells, Ning Kon, Wei Gu, Lisa M. Mehlmann, Srinivasan Vijayaraghavan, Manabu Kurokawa
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101523- (2020)
Summary: HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although HUWE1 is known to promote degradation of the tumor suppressor p53, given a growing list of its substrates, in vivo functions of HUWE1 remain elusive. Here, we
Externí odkaz:
https://doaj.org/article/641aafdd9ee84fdaa7cd93a2aaed9b62
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 2 (2020)
Acquired resistance to anti-HER2 therapy is a significant clinical challenge in breast cancer. We recently discovered that during acquisition of resistance to HER2 inhibition, upregulation of the fatty acid transporter CD36 takes place, playing a key
Externí odkaz:
https://doaj.org/article/f0fd63e09bd140a8b541aec74ae394e5
Autor:
William W. Feng, Owen Wilkins, Scott Bang, Matthew Ung, Jiaqi Li, Jennifer An, Carmen del Genio, Kaleigh Canfield, James DiRenzo, Wendy Wells, Arti Gaur, R. Brooks Robey, Jessie Yanxiang Guo, Ryan L. Powles, Christos Sotiriou, Lajos Pusztai, Maria Febbraio, Chao Cheng, William B. Kinlaw, Manabu Kurokawa
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3405-3420.e5 (2019)
Summary: Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of resistance to HER2 inhibition, metabolic rewiring of brea
Externí odkaz:
https://doaj.org/article/a14657a83c5e46c19bc58549304e0355
Autor:
Joshua L. Andersen, Manabu Kurokawa, Stephen R. Piccolo, Katherine K. McCormack, Tyler Heaton, Sandeep Kaur, Christina M. Egbert, Eranga R. Balasooriya, Riley Eastmond, A.G. Pramoda Sahankumari, Colin M. Muir, James Woods, Colten M. McEwan, Katie L. Pennington
Supplementary Data from SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd2530ec18e4c0a4f29f3de7cdca194
https://doi.org/10.1158/1541-7786.22527332
https://doi.org/10.1158/1541-7786.22527332
Autor:
Joshua L. Andersen, Manabu Kurokawa, Stephen R. Piccolo, Katherine K. McCormack, Tyler Heaton, Sandeep Kaur, Christina M. Egbert, Eranga R. Balasooriya, Riley Eastmond, A.G. Pramoda Sahankumari, Colin M. Muir, James Woods, Colten M. McEwan, Katie L. Pennington
PTOV1 is an oncogenic protein, initially identified in prostate cancer, that promotes proliferation, cell motility, and invasiveness. However, the mechanisms that regulate PTOV1 remain unclear. Here, we identify 14-3-3 as a PTOV1 interactor and show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6fdb6793264658472e0f6cde850d6ff
https://doi.org/10.1158/1541-7786.c.6545390.v1
https://doi.org/10.1158/1541-7786.c.6545390.v1