Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Manabu, Igarashi"'
Autor:
Yoko Fujita-Fujiharu, Yukihiko Sugita, Yuki Takamatsu, Kazuya Houri, Manabu Igarashi, Yukiko Muramoto, Masahiro Nakano, Yugo Tsunoda, Ichiro Taniguchi, Stephan Becker, Takeshi Noda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Marburg virus causes severe hemorrhagic fever in humans. Here, the authors determine the structure of Marburg virus nucleoprotein–RNA complex by cryo-electron microscopy and provide mechanistic insight into the helical assembly of the nucleocapsid.
Externí odkaz:
https://doaj.org/article/3bb5abd022ad48579c8ac63fd0191e66
Autor:
Takanari Hattori, Takeshi Saito, Kosuke Okuya, Yuji Takahashi, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 have a single envelope glycoprotein (S protein) that binds to human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. Previous mutational scanning studie
Externí odkaz:
https://doaj.org/article/af21a0c36b4d44d2b9227cbb89d0976c
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Externí odkaz:
https://doaj.org/article/2ec2189464f945cbaa831c4abf17bdf6
Autor:
Takanari Hattori, Takeshi Saito, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada
Publikováno v:
Viruses, Vol 14, Iss 10, p 2124 (2022)
Human T-cell immunoglobulin mucin 1 (hTIM-1) is known to promote cellular entry of enveloped viruses. Previous studies suggested that the polymorphisms of hTIM-1 affected its function. Here, we analyzed single nucleotide variants (SNVs) of hTIM-1 to
Externí odkaz:
https://doaj.org/article/858a6477d63b426da872a8f1dafe8a57
Publikováno v:
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Externí odkaz:
https://doaj.org/article/2600a498d4e2469b943d215ca8de91f2
Autor:
Boniface Pongombo Lombe, Takeshi Saito, Hiroko Miyamoto, Akina Mori-Kajihara, Masahiro Kajihara, Masayuki Saijo, Justin Masumu, Takanari Hattori, Manabu Igarashi, Ayato Takada
Publikováno v:
Viruses, Vol 14, Iss 3, p 544 (2022)
Crimean-Congo hemorrhagic fever virus (CCHFV), a nairovirus, is a tick-borne zoonotic virus that causes hemorrhagic fever in humans. The CCHFV nucleoprotein (NP) is the antigen most used for serological screening of CCHFV infection in animals and hum
Externí odkaz:
https://doaj.org/article/b81950d442a74246bdec6d7e6205446e
Autor:
Nodoka Kasajima, Keita Matsuno, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada
Publikováno v:
Viruses, Vol 13, Iss 11, p 2316 (2021)
Viral protein 35 (VP35) of Ebola virus (EBOV) is a multifunctional protein that mainly acts as a viral polymerase cofactor and an interferon antagonist. VP35 interacts with the viral nucleoprotein (NP) and double-stranded RNA for viral RNA transcript
Externí odkaz:
https://doaj.org/article/a0527a5bb6704eb7a1e2b8a7c96745d7
Autor:
Yoshihiro Takadate, Tatsunari Kondoh, Manabu Igarashi, Junki Maruyama, Rashid Manzoor, Hirohito Ogawa, Masahiro Kajihara, Wakako Furuyama, Masahiro Sato, Hiroko Miyamoto, Reiko Yoshida, Terence E. Hill, Alexander N. Freiberg, Heinz Feldmann, Andrea Marzi, Ayato Takada
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 308-319.e5 (2020)
Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Her
Externí odkaz:
https://doaj.org/article/29451c661e484aeab888802defbd12bd
Autor:
Taksoo Kim, Loc Tan Huynh, Shizuka Hirose, Manabu Igarashi, Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda
Publikováno v:
Viruses, Vol 13, Iss 8, p 1672 (2021)
The GPE− strain is a live attenuated vaccine for classical swine fever (CSF) developed in Japan. In the context of increasing attention for the differentiating infected from vaccinated animals (DIVA) concept, the achievement of CSF eradication with
Externí odkaz:
https://doaj.org/article/aae876a10c3a4f418ac33e4224c6ec56
Publikováno v:
Viruses, Vol 13, Iss 5, p 913 (2021)
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to th
Externí odkaz:
https://doaj.org/article/8214a536a4df4310bfb257174dc493b8