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Autor:
Hiroshi Morioka, Yuki Inada, Yoshihiro Kobashigawa, Takashi Sato, Yuu Kimoto, Soichiro Yamauchi, Yuya Toyota, Kyo Okazaki, Mana Namikawa, Mitsuhiro Sekiguchi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:125-130
The constitutive active/androstane receptor (CAR) is a nuclear receptor that functions as a xenobiotic sensor, which regulates the expression of enzymes involved in drug metabolism and of efflux transporters. Evaluation of the binding properties betw