Phenotypic analysis of catastrophic childhood epilepsy genes

Autor: Aliesha Griffin, Colleen Carpenter, Jing Liu, Rosalia Paterno, Brian Grone, Kyla Hamling, Maia Moog, Matthew T. Dinday, Francisco Figueroa, Mana Anvar, Chinwendu Ononuju, Tony Qu, Scott C. Baraban

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assay

Externí odkaz: https://doaj.org/article/bfcda728977044beb624cc6204edc73f

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening

Autor: Aliesha Griffin, Kyla R. Hamling, SoonGweon Hong, Mana Anvar, Luke P. Lee, Scott C. Baraban

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Epilepsy is a common chronic neurological disease affecting almost 3 million people in the United States and 50 million people worldwide. Despite availability of more than two dozen FDA-approved anti-epileptic drugs (AEDs), one-third of patients fail

Externí odkaz: https://doaj.org/article/99a549dff9744caba03bb048fee2a463

Phenotypic analysis of catastrophic childhood epilepsy genes

Autor: Aliesha Griffin, Chinwendu Ononuju, Kyla R. Hamling, Francisco Figueroa, Scott C. Baraban, Rosalia Paterno, Colleen Carpenter, Maia Moog, Matthew T. Dinday, Brian P. Grone, Mana Anvar, Tony Qu, Jing Liu

Publikováno v: Communications Biology
Communications biology, vol 4, iss 1
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but zebrafish-based human disease studies, and particularly for neurological disorders, are limited. Here we used CRISPR-Cas9 to gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ff37025ff7c415601aebd9401a079f
https://pubmed.ncbi.nlm.nih.gov/34083748

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening

Autor: SoonGweon Hong, Aliesha Griffin, Scott C. Baraban, Luke P. Lee, Mana Anvar, Kyla R. Hamling

Publikováno v: Griffin, A; Hamling, KR; Hong, S; Anvar, M; Lee, LP; & Baraban, SC. (2018). Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening. FRONTIERS IN PHARMACOLOGY, 9. doi: 10.3389/fphar.2018.00573. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6jv422r5
Frontiers in Pharmacology, Vol 9 (2018)

Epilepsy is a common chronic neurological disease affecting almost 3 million people in the United States and 50 million people worldwide. Despite availability of more than two dozen FDA-approved anti-epileptic drugs (AEDs), one-third of patients fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e3e88557566e88a549b61cd94f55e9
http://www.escholarship.org/uc/item/6jv422r5