Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Man-jun Li"'
Autor:
Lin Chen, Wen-qi Liu, Jia-hui Lei, Fei Guan, Man-jun Li, Wen-jian Song, Yong-long Li, Ting Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51512 (2012)
BACKGROUND: Hepatitis B and schistosomiasis are most prevalent in Africa and Asia, and co-infections of both are frequent in these areas. The immunomodulation reported to be induced by schistosome infections might restrict immune control of hepatitis
Externí odkaz:
https://doaj.org/article/315550ab1f244902b3c304046d5af796
Autor:
Saiful Islam, Ahmed Abdelaziz, Cobus Gerber, Sunita K.C. Basnet, Shudong Wang, Hugo Albrecht, Solomon Tadesse, Man-jun Li, Mingfeng Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2650-2654
Post-translational modulation of eIF4E through phosphorylation by Mnks is highly integral to the pathogenesis of different cancers. Therefore, inhibition of Mnks offers a strategy for cancer treatment. Herein, a series of 2'H-spiro[cyclohexane-1,3'-i
Autor:
Theodosia Teo, Mingfeng Yu, Shudong Wang, Yuchao Yang, Benjamin Noll, Man-jun Li, Yi Long, Stephen Philip
Publikováno v:
European journal of medicinal chemistry. 218
CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on our initial discovery of
Autor:
Hugo Albrecht, Solomon Tadesse, Matthew J. Sykes, Nishat Zareen Khair, Shudong Wang, Malika Kumarasiri, Jimma L Lenjisa, Robert W. Milne, Laychiluh B. Mekonnen, Sarah Diab, Man-jun Li, Sunita K.C. Basnet
Publikováno v:
ACS Med Chem Lett
Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683ff5cd65cd9dc6bcc6078b1453b846
https://europepmc.org/articles/PMC6511963/
https://europepmc.org/articles/PMC6511963/
Autor:
Muhammed H. Rahaman, John D. Hayball, Theodosia Teo, Stephen Philip, Laychiluh B. Mekonnen, Shudong Wang, Yi Long, Man-jun Li, Preethi Eldi, Mingfeng Yu, Benjamin Noll, Gary K. Heinemann, Yuchao Yang, Abel Tesfaye Anshabo, Robert W. Milne, Sarah Diab
Publikováno v:
European Journal of Medicinal Chemistry. 214:113248
CDK8 regulates transcription either by phosphorylation of transcription factors or, as part of a four-subunit kinase module, through a reversible association of the kinase module with the Mediator complex, a highly conserved transcriptional coactivat
Publikováno v:
Experimental Parasitology. 128:427-432
Cimetidine (CIM), a histamine-2-receptor antagonist, has a long history of safe use in gastric acid-mediated gastrointestinal disorders. In this study, we used CIM, as an adjuvant, with pEGFP-Sj26 GST (the recombinant plasmid containing enhanced gree
Autor:
Wen-qi Liu, Ting Wang, Man-jun Li, Lin Chen, Wen-jian Song, Fei Guan, Jia-hui Lei, Yong-long Li
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51512 (2012)
PLoS ONE
PLoS ONE
Background: Hepatitis B and schistosomiasis are most prevalent in Africa and Asia, and co-infections of both are frequent in these areas. The immunomodulation reported to be induced by schistosome infections might restrict immune control of hepatitis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c7b314720091d6ad1dcd58f0d2168a
https://hdl.handle.net/11541.2/138115
https://hdl.handle.net/11541.2/138115
Autor:
Yun-fan, Yang, Qian, Sun, Bin-tao, Su, Lin, Lin, Man-jun, Li, Lin, Chen, Hong, Xu, Jia-hui, Lei, Wen-qi, Liu, Yong-long, Li
Publikováno v:
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitologyparasitic diseases. 29(2)
To investigate the effect of ageing on the immune responses against Schistosoma japonicum infection in mice.Female BALB/c mice were divided into young group (2 months) and old group (18 months), each composed of 8 mice. Each mouse was percutaneously
Autor:
Yu-li Chen, Cheng-song Sun, Yong-long Li, Chun-lian Tang, Jia-hui Lei, Man-jun Li, Wen-qi Liu
We developed a novel immunomagnetic bead ELISA based on IgY (egg yolk immunoglobulin) for detection of circulating antigen (CA) in sera of mice infected with Schistosoma japonicum. The assay involved the use of chicken polyclonal antibodies IgY again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d1ee1ae4ae5fc1afabe638528af99
https://hdl.handle.net/11541.2/138193
https://hdl.handle.net/11541.2/138193
Publikováno v:
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitologyparasitic diseases. 20(1)
To observe the change of ornithine decarboxylase(ODC) activity in cells from adult Schistosoma japonicum after the cells were treated with N-Methyl-N-Nitro-N-Nitrosoguanidine (MNNG).The cells were treated with MNNG at a concentration of 3 micrograms/