Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Man-cheng Tang"'
Autor:
Wan-Hong Wen, Yue Zhang, Ying-Ying Zhang, Qian Yu, Chu-Chu Jiang, Man-Cheng Tang, Jin-Yue Pu, Lian Wu, Yi-Lei Zhao, Ting Shi, Jiahai Zhou, Gong-Li Tang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Antibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in nap
Externí odkaz:
https://doaj.org/article/a9d68f79ffe343329d07e275519c194a
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1444 (2022)
l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building block or biosynthetic precursor to bioactive natural products. Recent studies revealed that l-Kyn can be incorporated via nonribosomal peptide syntheta
Externí odkaz:
https://doaj.org/article/be4a19d1d6a445c4880f7398d2e20ca7
Autor:
Xiaozheng Wang, Dekun Kong, Tingting Huang, Fei Xu, Man-Cheng Tang, Zixin Deng, Shuangjun Lin
Publikováno v:
ACS Chemical Biology. 17:3499-3506
β-Carboline (βC) alkaloids constitute a large family of indole alkaloids that exhibit diverse pharmacological properties, such as antitumor, antiviral, antiparasitic, and antimicrobial activities. Here, we report that a flavoprotein StnP2 catalyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa53b9d6a69af76ada1428059b053fb1
https://doi.org/10.1021/acschembio.2c00704
https://doi.org/10.1021/acschembio.2c00704
Publikováno v:
Org Lett
Terpenoids are an important class of natural products with diverse structures and bioactivities. Their hydrocarbon scaffolds are mainly derived from the terpenes produced by terpene cyclases (TCs). Otherwise, new hydrocarbon scaffolds can be achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4463682cfc2b3d3d7fd3824eb83970de
https://doi.org/10.1021/acs.orglett.2c01785
https://doi.org/10.1021/acs.orglett.2c01785
Autor:
Cui Yu, Lin Chen, Yang Le Gao, Jia Liu, Pei Lin Li, Ming Liang Zhang, Qin Li, Huai Dong Zhang, Man Cheng Tang, Li Li
Publikováno v:
Frontiers in Microbiology. 13
3-Decalinoyltetramic acids (DTAs) are a class of natural products with chemical diversity and potent bioactivities. In fungal species there is a general biosynthetic route to synthesize this type of compounds, which usually features a polyketide synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb6e9e53fa95217cfed1e29fc184dee
Autor:
Mingzhe Li, Yongxiang Song, Jianhua Ju, Nai-Kei Wong, Jiafan Yang, Man-Cheng Tang, Junwei Deng
Publikováno v:
The Journal of Organic Chemistry. 86:11107-11116
A genome-directed discovery strategy to identify new tetrahydroisoquinolines (THIQs) was applied to deep-sea derived Streptomyces niveus SCSIO 3406; 11 THIQs were found representing three THIQ clas...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14c0d74f9078baeea986500a7243205
https://doi.org/10.1021/acs.joc.1c00123
https://doi.org/10.1021/acs.joc.1c00123
Autor:
Guangzheng Wei, Guomin Ai, Shu-Shan Gao, Kexin Zhang, Man-cheng Tang, Jun Zhang, Xian Shu, Yonghui Zhang, Yuben Qiao
Publikováno v:
Organic letters. 23(22)
The flavoprotein monooxygenase (FPMO) TerC is encoded by all known cyclopentene biosynthetic gene clusters. It can catalyze oxidative dearomatization toward a series of 6-HM analogues and further induces different skeletal distortions to form either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680c51e61da46216c0ce46883179fd30
https://pubmed.ncbi.nlm.nih.gov/34743520
https://pubmed.ncbi.nlm.nih.gov/34743520
Autor:
Neil K. Garg, Man-Cheng Tang, Dan Tan, Zhuan Zhang, Molly Miranda, Yi Tang, Robert P. St.Onge, Curt R. Fischer, Angela Chu, Jason V. Chari, Justin D. Smith, Sundari Suresh
Publikováno v:
J Am Chem Soc
Fungal highly reducing polyketide synthases (HRPKSs) biosynthesize polyketides using a single set of domains iteratively. Product release is a critical step in HRPKS function to ensure timely termination and enzyme turnover. Nearly all of the HRPKSs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91540f5ccbdbafe10df033ef86dcb15f
https://doi.org/10.1021/jacs.9b01083
https://doi.org/10.1021/jacs.9b01083
Autor:
Masao, Ohashi, Thomas B, Kakule, Man-Cheng, Tang, Cooper S, Jamieson, Mengting, Liu, Yi-Lei, Zhao, Kendall N, Houk, Yi, Tang
Publikováno v:
J Am Chem Soc
Hirsutellones are fungal natural products containing a macrocyclic para-cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B (3) and GKK1032 A(2) (4). Two small hypothetical proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::045f58db86216b7a5b36eb829b89a023
https://pubmed.ncbi.nlm.nih.gov/33834778
https://pubmed.ncbi.nlm.nih.gov/33834778
Autor:
Mengting Liu, Man-Cheng Tang, Cooper S. Jamieson, Yi-Lei Zhao, Thomas B. Kakule, Masao Ohashi, Kendall N. Houk, Yi Tang
Publikováno v:
Journal of the American Chemical Society, vol 143, iss 15
Hirsutellones are fungal natural products containing a macrocyclic para-cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B (3) and GKK1032 A2 (4). Two small hypothetical proteins, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71a0acd66833da0e423ad1bc2713e39
https://escholarship.org/uc/item/4c92772d
https://escholarship.org/uc/item/4c92772d
