Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Man-Wah Tan"'
Autor:
Chun Kew, Cristian Prieto-Garcia, Anshu Bhattacharya, Manuela Tietgen, Craig R. MacNair, Lindsey A. Carfrae, João Mello-Vieira, Stephan Klatt, Yi-Lin Cheng, Rajeshwari Rathore, Elise Gradhand, Ingrid Fleming, Man-Wah Tan, Stephan Göttig, Volkhard A. J. Kempf, Ivan Dikic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Acinetobacter baumannii is a pathogenic and multidrug-resistant Gram-negative bacterium that causes severe nosocomial infections. To better understand the mechanism of pathogenesis, we compare the proteomes of uninfected and infected human c
Externí odkaz:
https://doaj.org/article/cc857566b9914285a523bd2ab2b86cfe
Autor:
Jordan S. Mar, Naruhisa Ota, Nick D. Pokorzynski, Yutian Peng, Allan Jaochico, Dewakar Sangaraju, Elizabeth Skippington, Annemarie N. Lekkerkerker, Michael E. Rothenberg, Man-Wah Tan, Tangsheng Yi, Mary E. Keir
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation
Externí odkaz:
https://doaj.org/article/07f3567e2214401ab5134a8634835824
Autor:
Elena K. Perry, Man-Wah Tan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Bacterial biofilms can be found in most environments on our planet, and the human body is no exception. Consisting of microbial cells encased in a matrix of extracellular polymers, biofilms enable bacteria to sequester themselves in favorable niches,
Externí odkaz:
https://doaj.org/article/275dba7abdab4bad868a71c6c21c1553
Publikováno v:
Antibiotics, Vol 12, Iss 8, p 1267 (2023)
Antibiotics found in and inspired by nature are life-saving cures for bacterial infections and have enabled modern medicine. However, the rise in resistance necessitates the discovery and development of novel antibiotics and alternative treatment str
Externí odkaz:
https://doaj.org/article/3937ff08f20f4da0a9f24ae247d3eef9
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Acinetobacter baumannii is a highly pathogenic Gram-negative bacterium that causes severe infections with very high fatality rates. A. baumannii infection triggers innate as well as adaptive immunity, however, our understanding of the inflammatory fa
Externí odkaz:
https://doaj.org/article/698410c372334f9fab9cdca011bb5415
Autor:
Varnesh Tiku, Eric M. Kofoed, Donghong Yan, Jing Kang, Min Xu, Mike Reichelt, Ivan Dikic, Man-Wah Tan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Acinetobacter baumannii is a highly antibiotic resistant Gram-negative bacterium that causes life-threatening infections in humans with a very high mortality rate. A. baumannii is an extracellular pathogen with poorly understood virulence me
Externí odkaz:
https://doaj.org/article/e2acf545e8914bfdbf0d125959f80a3a
Publikováno v:
Microbial Cell, Vol 4, Iss 4, Pp 108-111 (2017)
Secretion of proteins into the extracellular environment is crucial for the normal physiology and virulence of pathogenic bacteria. Type I signal peptidase (SPase I) mediates the final step of bacterial secretion, by cleaving proteins at their signal
Externí odkaz:
https://doaj.org/article/84dde039ea594003a7f4b6e146ce82cf
Autor:
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mic
Externí odkaz:
https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf047
Publikováno v:
Biology Open, Vol 3, Iss 7, Pp 644-655 (2014)
Amidst growing concerns over the spread of antibiotic-resistant Staphylococcus aureus strains, the identification of alternative therapeutic molecules has become paramount. Previously, we utilized a Caenorhabditis elegans–S. aureus screening platfo
Externí odkaz:
https://doaj.org/article/3161d9a1e4b0484691084e0f323e2920
Autor:
J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB
Externí odkaz:
https://doaj.org/article/3b9f916136964f4eb118797ed067be1e