Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Man-Tzu Wang"'
Autor:
Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A. Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
KRAS mutations are frequent in pancreatic ductal adenocarcinoma, leading to bad prognosis and resistance to targeted therapies. Here, the authors show that LIF expression is specifically induced by KRAS and constitutes a potential target to treat the
Externí odkaz:
https://doaj.org/article/1264485d73e0466695383206f5054dba
Autor:
Tejashree Joglekar, Albert Ku, Ethan Schollaert, Yinan Gong, Jacob Stewart-Ornstein, Anatoly Urisman, Man-Tzu Wang
Oncogenic KRAS-driven cancers have long been considered as “undruggable” due to limited therapeutic options. While the recent success of KRAS-G12C inhibitors argues against the “undruggability” of KRAS, this treatment only benefits a small pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6144123b9bd5cd05e22f5a495ed5ff0f
https://doi.org/10.1101/2022.05.24.493257
https://doi.org/10.1101/2022.05.24.493257
Autor:
Weihong Wang, Joshua S. Prokopec, Yixin Zhang, Maria Sukhoplyasova, Himaly Shinglot, Man-Tzu Wang, Andreas Linkermann, Jacob Stewart-Ornstein, Yi-Nan Gong
Publikováno v:
Dev Cell
Although overwhelming plasma membrane integrity loss leads to cell lysis and necrosis, cells can tolerate a limited level of plasma membrane damage, undergo ESCRT-III-mediated repair, and survive. Here, we find that cells which undergo limited plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f57b89b3714020f7ce0bfc268fe583d
https://europepmc.org/articles/PMC8792343/
https://europepmc.org/articles/PMC8792343/
Autor:
Man-Tzu Wang, Frank McCormick, Allan Balmain, Matthew Holderfield, Reyno Delrosario, Jacqueline Galeas, Minh D. To
Publikováno v:
Cell. 163(5):1237-1251
SummaryK-Ras and H-Ras share identical effectors and have similar properties; however, the high degree of tumor-type specificity associated with K-Ras and H-Ras mutations suggests that they have unique roles in oncogenesis. Here, we report that oncog
Autor:
Sung Eun Kim, Jeremy Sharib, Eric A. Collisson, Nicole Fer, Frank McCormick, Man Tzu Wang, Jacqueline Galeas
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature communications, vol 10, iss 1
KRAS mutations are present in over 90% of pancreatic ductal adenocarcinomas (PDAC), and drive their poor outcomes and failure to respond to targeted therapies. Here we show that Leukemia Inhibitory Factor (LIF) expression is induced specifically by o
Publikováno v:
Cancer Research. 78:2277-2277
Cell free DNA (cfDNA), a form of ‘liquid biopsy', has recently emerged as a promising technology to screen, diagnose, and monitor many types of disease. However, in the context of cancer, one unfortunate complication of cfDNA's use as a biomarker i
Publikováno v:
Molecular Cancer Therapeutics. 17:B048-B048
The extremely high mutation rate of KRAS in three of the top four deadly cancers (lung, colon, and pancreas) makes it a major target in anticancer drug discovery. However, no effective anti-KRAS inhibitors have yet been developed into clinically usef
Autor:
Yakun Chen, Man-Tzu Wang, Hongmei Jiang, Gregory J. Brewer, Keshav K. Singh, Krishna Rao, Yong Tang, Dianer Yang, Daotai Nie, Torrie T. Jones
Publikováno v:
Cancer Biology & Therapy. 9:122-133
A common metabolic change in cancer is the acquisition of glycolytic phenotypes. Increased expression of glycolytic enzymes is considered as one contributing factor. The role of mitochondrial defects in acquisition of glycolytic phenotypes has been p
Autor:
Dianer Yang, Daotai Nie, Yong Tang, Man Tzu Wang, Stephen R. Johnson, Gregory D. Akers, Yakun Chen, Kenneth V. Honn, Mingxin Che
Publikováno v:
International Journal of Cancer. 124:1545-1551
The enzyme 15-lipoxygenase-2 (15-LOX-2) utilizes arachidonic acid, a polyunsaturated fatty acid, to synthesize 15(S)-hydroxyeicosatetraenoic acid (HETE). Abundantly expressed in normal prostate epithelium but frequently suppressed in the cancerous ti
Autor:
Alex Zacharek, Yande Guo, Yong Tang, Kenneth V. Honn, Mingxin Che, Man Tzu Wang, Daotai Nie, Yakun Chen, Yan Qiao, Dianer Yang
Publikováno v:
Cancer Research. 68:115-121
Thromboxane A2 (TxA2) is a prostanoid formed by thromboxane synthase using the cyclooxygenase product prostaglandin H2 as the substrate. Previously, increased expression of thromboxane synthase was found in prostate tumors, and tumor cell motility wa