Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Man-Tat Lau"'
Autor:
Man-Tat Lau, Shila Ghazanfar, Ashleigh Parkin, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Danielle Nessem, Thang M. Khuong, Damien Nevoltris, Peter Schofield, David Langley, Daniel Christ, Jean Yang, Marina Pajic, G. Gregory Neely
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In ad
Externí odkaz:
https://doaj.org/article/c47471a679ca416996391ad2844c7411
Autor:
Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-ind
Externí odkaz:
https://doaj.org/article/7783b05d2b904dac8b8436b3b11b2579
Autor:
Qiao-Ping Wang, Yong Qi Lin, Mei-Ling Lai, Zhiduan Su, Lisa J. Oyston, Teleri Clark, Scarlet J. Park, Thang M. Khuong, Man-Tat Lau, Victoria Shenton, Yan-Chuan Shi, David E. James, William W. Ja, Herbert Herzog, Stephen J. Simpson, G. Gregory Neely
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive to extrinsic factors like diet, and this occurs by un
Externí odkaz:
https://doaj.org/article/59c335b1afda413f96e094fbfa26b456
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/452861dfef4b48afb0328c3c5d50aa04
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59083 (2013)
Fibroblast growth factor 2 (FGF2) is produced by ovarian cancer cells and it has been suggested to play an important role in tumor progression. In this study, we report that FGF2 treatment down-regulated E-cadherin by up-regulating its transcriptiona
Externí odkaz:
https://doaj.org/article/545b5f9ccb764287ab474deee7ce6293
Autor:
Peter R. Schofield, Man-Tat Lau, Jean Yang, David B. Langley, Thang M. Khuong, Danielle Nessem, Marina Pajic, Daniel Christ, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Damien Nevoltris, Shila Ghazanfar, G. Gregory Neely, Ashleigh Parkin
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Genome Biology
Genome Biology
Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In addition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922824cb7feafff70032b0460cca2622
https://doaj.org/article/c47471a679ca416996391ad2844c7411
https://doaj.org/article/c47471a679ca416996391ad2844c7411
Autor:
G. Gregory Neely, Zhiduan Su, Thang M. Khuong, David E. James, Mei-Ling Lai, William W. Ja, Scarlet J. Park, Lisa J. Oyston, Qiao-Ping Wang, Man-Tat Lau, Yong Qi Lin, Yan-Chuan Shi, Victoria Shenton, Stephen J. Simpson, Herbert Herzog, Teleri Clark
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Summary: Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive to extrinsic factors like diet, and this occurs by un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b91cf966b0499a13b967f04427ca4
http://www.sciencedirect.com/science/article/pii/S2211124720303582
http://www.sciencedirect.com/science/article/pii/S2211124720303582
Autor:
Teleri Clark, Man-Tat Lau, Yong Qi Lin, G. Gregory Neely, Lisa J. Oyston, Qiao-Ping Wang, Thang M. Khuong
Publikováno v:
Cell Stress, Vol 2, Iss 9, Pp 225-232 (2018)
Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63c5827a462f14499d76b49fddf67a5
https://doi.org/10.15698/cst2018.09.152
https://doi.org/10.15698/cst2018.09.152
Autor:
John Manion, Thang M. Khuong, Qiao-Ping Wang, Man-Tat Lau, G. Gregory Neely, Harry Towler, Lisa J. Oyston, Yong Qi Lin
Publikováno v:
Science Advances. 5
Injury can lead to devastating and often untreatable chronic pain. While acute pain perception (nociception) evolved more than 500 million years ago, virtually nothing is known about the molecular origin of chronic pain. Here we provide the first evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049d57ca816b82c0041cc7332a09b171
https://doi.org/10.1126/sciadv.aaw4099
https://doi.org/10.1126/sciadv.aaw4099
Autor:
Lisa J, Oyston, Yong Qi, Lin, Thang M, Khuong, Qiao-Ping, Wang, Man Tat, Lau, Teleri, Clark, G Gregory, Neely
Publikováno v:
Cell Stress
Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0368ed6c3ace3fcc66d8f325cca950e
https://pubmed.ncbi.nlm.nih.gov/31225490
https://pubmed.ncbi.nlm.nih.gov/31225490