Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Man-Shan Yu"'
Autor:
Brady P. Culver, Man-Shan Yu, Igor Dolgalev, Josh DeClercq, Adriana Heguy, Naoko Tanese, Bin Ma
Publikováno v:
Journal of Huntington's Disease
Background: The Huntington’s disease (HD) protein huntingtin (Htt) plays a role in multiple cellular pathways. Deregulation of one or more of these pathways by the mutant Htt protein has been suggested to contribute to the disease pathogenesis. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49dec204d78252024c640c0b179a235
https://doi.org/10.3233/jhd-150177
https://doi.org/10.3233/jhd-150177
Autor:
Man-Shan Yu, Naoko Tanese
Publikováno v:
Frontiers in Cellular Neuroscience
Mutation in the huntingtin (HTT) gene causes Huntington’s disease. It is an autosomal dominant trinucleotide-repeat expansion disease in which CAG repeat sequence expands to >35. This results in the production of mutant HTT protein with an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b167a9f74aef10dab6750ef9be531b
http://europepmc.org/articles/PMC5318384
http://europepmc.org/articles/PMC5318384
Autor:
Yuen-Shan Ho1,2, Man-Shan Yu1, Xi-Fei Yang1, Kwok-Fai So1,2,3, Wai-Hung Yuen4, Chuen-Chung Chang, Raymond1,2,3 rccchang@hku.hk
Publikováno v:
Journal of Alzheimer's Disease. 2010, Vol. 19 Issue 3, p813-827. 15p. 7 Graphs.
Autor:
Kwok-Fai So, Man-Shan Yu, Cora Sau Wan Lai, Natalie Qishan Zhang, YT Cheung, Raymond Chuen-Chung Chang, Clara Hiu-Ling Hung
Publikováno v:
Journal of Cellular and Molecular Medicine
Alzheimer's disease (AD) is an aging-related progressive neurodegenerative disorder. Previous studies suggested that various soluble Aβ species are neurotoxic and able to activate apoptosis and autophagy, the type I and type II programmed cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7130cc3980a5db543dab30706c5011
https://doi.org/10.1111/j.1582-4934.2009.00990.x
https://doi.org/10.1111/j.1582-4934.2009.00990.x
Publikováno v:
The Journal of Nutritional Biochemistry. 21:482-489
Resveratrol (3,4',5-trans-trihydroxystilbene) is a phytoalexin with emerging lines of evidence supporting its beneficial effects on cardiovascular systems and inhibition of carcinogenesis. It has also been reported that certain methylated resveratrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120cc5eb4367988c4a34e183019318c2
https://doi.org/10.1016/j.jnutbio.2009.02.004
https://doi.org/10.1016/j.jnutbio.2009.02.004
Publikováno v:
Journal of Alzheimer's Disease. 19:813-827
Previous clinical and epidemiological studies have suggested that elevated plasma homocysteine (Hcy) levels increased the risk of Alzheime's disease (AD). Although the underlying mechanisms of its toxicity are elusive, it has been shown that Hcy dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40fe39ce845526191f50b5e7929063e
https://doi.org/10.3233/jad-2010-1280
https://doi.org/10.3233/jad-2010-1280
Autor:
Wai Hung Yuen, Wai Har Lam, Yuen Shan Ho, Cora Sau Wan Lai, Man-Shan Yu, Jianfei Chao, Way K.W. Lau, Tak Hang Chan, Raymond Chuen-Chung Chang, Michelle Justine Huie, Mingfu Wang
Publikováno v:
Neuroscience Letters. 469:360-364
Regular consumption of green tea benefits people in prevention from cardiovascular disorders, obesity as well as neurodegenerative diseases. (-)-Epigallocatechin-3-gallate (EGCG) is regarded as the most biologically active catechin in green tea. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcc8e7ff7d7c52ec24c798a324c496b
https://doi.org/10.1016/j.neulet.2009.12.028
https://doi.org/10.1016/j.neulet.2009.12.028
Autor:
Yuen Shan Ho, Man-Shan Yu, Raymond Chuen-Chung Chang, Wai Hung Yuen, Suet Yi Yik, Kwok-Fai So
Publikováno v:
Cellular and Molecular Neurobiology. 29:1233-1244
Glutamate excitotoxicity is involved in many neurodegenerative diseases including Alzheimer's disease (AD). Attenuation of glutamate toxicity is one of the therapeutic strategies for AD. Wolfberry (Lycium barbarum) is a common ingredient in oriental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b1ac4165e78b3f8db8712caa695ab
https://doi.org/10.1007/s10571-009-9419-x
https://doi.org/10.1007/s10571-009-9419-x
Publikováno v:
Free Radical Biology and Medicine. 45:1019-1026
Oxyresveratrol (OXY) is a polyhydroxylated stilbene existing in mulberry. Increasing lines of evidence have shown its neuroprotective effects against Alzheimer disease and stroke. However, little is known about its neuroprotective effect in Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffd975ed2e41d4fd090190aa072cbb1
https://doi.org/10.1016/j.freeradbiomed.2008.07.002
https://doi.org/10.1016/j.freeradbiomed.2008.07.002
Publikováno v:
Brain Research. 1190:215-224
Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to promote health and longevity. Synaptic degeneration is another key mode of neurodegeneration in Alzheimer's disease (AD). Recent studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d792f8f15b7da71e54026669f64e492
https://doi.org/10.1016/j.brainres.2007.10.103
https://doi.org/10.1016/j.brainres.2007.10.103