Decyl caffeic acid inhibits the proliferation of colorectal cancer cells in an autophagy-dependent manner in vitro and in vivo.

Autor: Ching Chen, Yueh-Hsiung Kuo, Cheng-Chieh Lin, Che-Yi Chao, Man-Hui Pai, En-Pei Isabel Chiang, Feng-Yao Tang

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232832 (2020)

The treatment of human colorectal cancer (CRC) cells through suppressing the abnormal survival signaling pathways has recently become a significant area of focus. In this study, our results demonstrated that decyl caffeic acid (DC), one of the novel

Externí odkaz: https://doaj.org/article/8fc743ce10db4fbea30dd179f9465aef

Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.

Autor: Ying-Wen Su, Yun-Ho Lin, Man-Hui Pai, An-Chi Lo, Yu-Chieh Lee, I-Chih Fang, Johnson Lin, Ruey-Kuen Hsieh, Yi-Fang Chang, Chi-Long Chen

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e96183 (2014)

BACKGROUND: Epidemiological studies have indicated that impaired glucose metabolism may increase the risk of squamous cell carcinoma of the head and neck (SCCHN). AMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phos

Externí odkaz: https://doaj.org/article/d03aac9d4747462191e2236ff37defd3

Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle Injuries

Autor: Ming-Tsan Lin, Man-Hui Pai, Yu-Chen Hou, Sung-Ling Yeh, Kuen-Yuan Chen, Po-Chu Lee, Po-Jen Yang, Jin-Ming Wu

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13003, p 13003 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13003
International Journal of Molecular Sciences

This study investigated the effects of l-glutamine (Gln) and/or l-leucine (Leu) administration on sepsis-induced skeletal muscle injuries. C57BL/6J mice were subjected to cecal ligation and puncture to induce polymicrobial sepsis and then given an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e488161226b497115011de8fda1d427d
https://www.mdpi.com/1422-0067/22/23/13003

Effects of dietary glutamine supplementation on immune cell polarization and muscle regeneration in diabetic mice with limb ischemia

Autor: Yu-Chen Hou, Cing Syuan Lei, Sung Ling Yeh, Man Hui Pai, Shiau Tsz Su

Publikováno v: European Journal of Nutrition. 59:921-933

Diabetes is a chronic inflammatory disorder resulting in endothelial dysfunction which contributes to peripheral arterial disease and limb ischemia. Leukocytes play critical roles in vascular and tissue remodelling after ischemia. This study investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3194aafbe119eeb4def5ef2e8bb5d2f
https://doi.org/10.1007/s00394-019-01951-4

Antecedent Dietary Glutamine Supplementation Benefits Modulation of Liver Pyroptosis in Mice with Polymicrobial Sepsis

Autor: Ming-Tsan Lin, Man Hui Pai, Sung Ling Yeh, Jin-Ming Wu, Po Jen Yang, Chun Chieh Huang, Po-Chu Lee

Publikováno v: Nutrients
Nutrients, Vol 12, Iss 1086, p 1086 (2020)
Volume 12
Issue 4

The liver is the main organ responsible for bacterial and endotoxin clearance. Pyroptosis is a form of proinflammatory programmed cell death activated by caspase-1/11 and gasdermin D (GadD). Pyroptosis protects the host against bacterial infection