Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Man Sup Kwak"'
Autor:
Jaemin Shin, Young Hun Kim, Bin Lee, Jae Ho Chang, Hee Youn Choi, Hoojung Lee, Ki Chan Song, Man Sup Kwak, Ji Eun Choi, Jeon-Soo Shin
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-13 (2022)
Abstract Background High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in response to inflammat
Externí odkaz:
https://doaj.org/article/853b66871fae4bbbb1f96fafd4e2e64e
Autor:
Cheol Ho Park, Bin Lee, Myeonggil Han, Woo Joong Rhee, Man Sup Kwak, Tae-Hyun Yoo, Jeon-Soo Shin
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Sodium-glucose cotransporter 2 inhibitors, which are recently introduced as glucose-lowering agents, improve cardiovascular and renal outcomes in patients with diabetes mellitus. These drugs also have beneficial effects in various kidney dis
Externí odkaz:
https://doaj.org/article/2e5f6e6ca7b140fe83d650b3004e7cbb
Autor:
Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son, Jeon-Soo Shin
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-13 (2021)
Abstract Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor
Externí odkaz:
https://doaj.org/article/7885de36e0e542ecaaa1794323d78818
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Although cellular senescence has emerged as a novel therapeutic concept in cancer, its underlying mechanisms remain unclear. High mobility group box 1 (HMGB1) and stimulator of interferon genes (STING) are involved in senescence. However, th
Externí odkaz:
https://doaj.org/article/1c071cc3555546859e472c704df520ad
Autor:
Man Sup Kwak, Woo Joong Rhee, Yong Joon Lee, Hee Sue Kim, Young Hun Kim, Min Kyung Kwon, Jeon-Soo Shin
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101858- (2021)
Oxidative stress can induce covalent disulfide bond formation between protein-protein thiol groups and generate hydroxyl free radicals that damage DNA. HMGB1 is a DNA chaperone and damage-associated molecular pattern molecule. As a redox-sensitive pr
Externí odkaz:
https://doaj.org/article/9a678b8090ac456f88c3a67e2c175754
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-dependent secretion pathway; however, some proteins, including a few danger-associated molecular patterns (DAMPs), are secreted via non-classical ER/Golgi-ind
Externí odkaz:
https://doaj.org/article/f7db2b585332434cb0a8fd70b4345f36
Sulfatide Inhibits HMGB1 Secretion by Hindering Toll-Like Receptor 4 Localization Within Lipid Rafts
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The high mobility group box 1 (HMGB1) is a well-known late mediator of sepsis, secreted by multiple stimuli, involving pathways, such as the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways, and reactive oxygen spe
Externí odkaz:
https://doaj.org/article/57dfef0bf8fe4d3faff5b40c8ca39e03
Autor:
Man Sup Kwak, Hee Sue Kim, Khulan Lkhamsuren, Young Hun Kim, Myeong Gil Han, Jae Min Shin, In Ho Park, Woo Joong Rhee, Se Kyoung Lee, Sue Goo Rhee, Jeon-Soo Shin
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulat
Externí odkaz:
https://doaj.org/article/23c7f8a9f2d64a25b0d41ecb1e19a09d
Autor:
Sook Young Kim, Myoungsun Son, Sang Eun Lee, In Ho Park, Man Sup Kwak, Myeonggil Han, Hyun Sook Lee, Eun Sook Kim, Jae-Young Kim, Jong Eun Lee, Ji Eun Choi, Betty Diamond, Jeon-Soo Shin
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
High-mobility group box 1 (HMGB1), a well-known danger-associated molecular pattern molecule, acts as a pro-inflammatory molecule when secreted by activated immune cells or released after necrotic cell damage. HMGB1 binds to immunogenic bacterial com
Externí odkaz:
https://doaj.org/article/89001eb9ca384d1e862700928818e48d
Autor:
Young Hun Kim, Jae Min Shin, In Ho Park, Sowon Aum, Bin Lee, Jeon Soo Shin, Min Goo Lee, Man Sup Kwak
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Nuclear protein HMGB1 is secreted in response to various stimuli and functions as a danger-associated molecular pattern. Extracellular HMGB1 induces inflammation, cytokine production, and immune cell recruitment via activation of various receptors. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0e8a946846c16cbdaf7d7faf7844e3
https://doi.org/10.1080/15548627.2020.1826690
https://doi.org/10.1080/15548627.2020.1826690