Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Man Shing Wong"'
Publikováno v:
Smart Materials in Medicine, Vol 4, Iss , Pp 286-293 (2023)
Chemodynamic therapy (CDT) has emerged as an effective and safe anticancer therapeutic strategy by catalytic generation of hydroxyl radicals via Fenton chemistry to kill notorious cancer cells. Herein, we decorated the Cu-based nanoparticles with pH-
Externí odkaz:
https://doaj.org/article/3fc5f86a435b43088c97aabf3c5c0a31
Autor:
Hongyu Lyu, Yongqin Ye, Vincent Chi Hang Lui, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Hung-Wing Li, Man Shing Wong, Paul Kwong Hang Tam, Bin Wang
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
BackgroundBiliary atresia (BA) is an infantile fibro-obstructive cholestatic disease with poor prognosis. An early diagnosis and timely Kasai portoenterostomy (KPE) improve clinical outcomes. Aggregation of amyloid-beta (Aβ) around hepatic bile duct
Externí odkaz:
https://doaj.org/article/413a2de983a3431faaa027097c20c71f
Autor:
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102280- (2022)
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in Alzheimer's disease (AD). Current medications for AD have faile
Externí odkaz:
https://doaj.org/article/17aea313beb2415fa02ef3251a86296c
Autor:
Yinhui Li, Chen Chen, Di Xu, Chung-Yan Poon, See-Lok Ho, Rui Zheng, Qiong Liu, Guoli Song, Hung-Wing Li, Man Shing Wong
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 6812-6819 (2018)
Externí odkaz:
https://doaj.org/article/b3148b56b48843069afff64a9712bee7
Autor:
Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung-Wing Li, Man Shing Wong
Publikováno v:
ACS Applied Materials & Interfaces. 15:39-47
Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by aggregated amyloid-β (Aβ) in Alzheimer's disease (AD). Tools that can direct
Autor:
Chen Chen, Xueli Wang, Di Xu, Hailong Zhang, Hei-Nga Chan, Zhonghao Zhan, Shizheng Jia, Qingting Song, Guoli Song, Hung-Wing Li, Man Shing Wong
Publikováno v:
Journal of Materials Chemistry B.
The multifunctional theranostic cyanine SLCOOH, capable of real-time imaging of Aβ contents in vivo and targeting multiple pathological pathways or mechanisms of neurodegeneration, was unambiguously demonstrated.
Autor:
Yinhui Li, Nicolas Desbois, Man Shing Wong, Frédéric Bolze, Claude P. Gros, Xueli Wang, Hei Nga Chan, Hung-Wing Li
Publikováno v:
ACS Applied Materials & Interfaces. 13:18525-18532
Despite the wide use of magnetic resonance imaging (MRI) as a clinical diagnostic tool, there are still no clinically approved MRI contrast agents that can be applied for cerebral Alzheimer's disease (AD) biomarker imaging. We report here the design
Autor:
Chen Zhang, Hung-Wing Li, Yuanyuan Ma, Zhongju Ye, Hai-Bin Luo, Man Shing Wong, Lehui Xiao, Xueli Wang
Publikováno v:
ACS Nano. 14:11341-11351
Deposition and aggregation of β-amyloid (Aβ) peptides are demonstrated to be closely related to the pathogenesis of Alzheimer's disease (AD). Development of functional molecules capable of visualizing Aβ1-40 aggregates with nanoscale resolution an
Publikováno v:
Journal of Materials Chemistry B. 8:10586-10592
A mitochondrial pH sensing fluorescent probe namely 2-(2-(6-hydroxynaphthalen-2-yl)vinyl)-3-(6-(triphenyl-phosphonio)hexyl)benzothiazol-3-ium bromide (HTBT2) was designed and facilely synthesized via the Knoevenagel condensation reaction. HTBT2 displ
Autor:
Bo Lin, Li Fan, Shaomin Shuang, Man Shing Wong, Zhonghua Zhao, Xiaodong Wang, Qi Zan, Chuan Dong, Xiaojuan Gong
Publikováno v:
The Analyst. 145:5657-5663
Hypoxia in solid tumors is directly linked to the elevated levels of endogenous nitroreductase (NTR). We present a novel fluorescent probe, namely NTNO, for nitroreductase-specific detection based on the NTR-catalyzed reduction of the nitro unit to a