Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Man Ru Wu"'
Autor:
Ziqian Xie, Tao Zhang, Sangbae Kim, Jiaxiong Lu, Wanheng Zhang, Cheng-Hui Lin, Man-Ru Wu, Alexander Davis, Roomasa Channa, Luca Giancardo, Han Chen, Sui Wang, Rui Chen, Degui Zhi
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011273 (2024)
Existing imaging genetics studies have been mostly limited in scope by using imaging-derived phenotypes defined by human experts. Here, leveraging new breakthroughs in self-supervised deep representation learning, we propose a new approach, image-bas
Externí odkaz:
https://doaj.org/article/abc589cd33a445cc845d1602561167a1
Autor:
Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112596- (2023)
Summary: Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle. We show that N6-methylad
Externí odkaz:
https://doaj.org/article/c135ad3f054e4a8ca78c9621cd901ff3
Autor:
Cheng-Hui Lin, Young Joo Sun, Soo Hyeon Lee, Elena M. Mujica, Caitlin R. Kunchur, Man-Ru Wu, Jing Yang, Youn Soo Jung, Bryce Chiang, Sui Wang, Vinit B. Mahajan
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101143- (2022)
Summary: Ocular drug implants (ODIs) are beneficial for treating ocular diseases. However, the lack of a robust injection approach for small-eyed model organisms has been a major technical limitation in developing ODIs. Here, we present a cost-effect
Externí odkaz:
https://doaj.org/article/c6541ccd293545ea8ee0602b6d77adb9
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 1, Pp 63-79 (2018)
Background/Aims: Blue light-emitting diode light (BLL)-induced phototoxicity plays an important role in ocular diseases and causes retinal degeneration and apoptosis in human retinal pigment epithelial (RPE) cells. Cistanche tubulosa extract (CTE) is
Externí odkaz:
https://doaj.org/article/f2ed9b776321419d9e146c5a5882a0e2
Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle. Here, we show that m6A (N6-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0826a68214a7ecb759cb29d5f0cf280f
https://doi.org/10.1101/2022.06.11.495708
https://doi.org/10.1101/2022.06.11.495708
Autor:
Ziqian Xie, Tao Zhang, Sangbae Kim, Jiaxiong Lu, Wanheng Zhang, Cheng-Hui Lin, Man-Ru Wu, Alexander Davis, Roomasa Channa, Luca Giancardo, Han Chen, Sui Wang, Rui Chen, Degui Zhi
Existing imaging genetics studies have been mostly limited in scope by using imaging-derived phenotypes defined by human experts. Here, leveraging new breakthroughs in self-supervised deep representation learning, we propose a new approach, image-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5595db601183e4d2d876633ea935b05a
https://doi.org/10.1101/2022.05.26.22275626
https://doi.org/10.1101/2022.05.26.22275626
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1799 (2019)
N-retinylidene-N-retinylethanolamine (A2E) and other bisretinoids are components of lipofuscin and accumulate in retinal pigment epithelial (RPE) cells—these adducts are recognized in the pathogenesis of retinal degeneration. Further, blue light-em
Externí odkaz:
https://doaj.org/article/80a794bd3a7c46faba9a1b2b5084f283
Autor:
Young Joo Sun, Cheng-Hui Lin, Man-Ru Wu, Soo Hyeon Lee, Jing Yang, Caitlin R. Kunchur, Elena M. Mujica, Bryce Chiang, Youn Soo Jung, Sui Wang, Vinit B. Mahajan
Publikováno v:
Cell reports methods
SUMMARY Using small molecule drugs to treat eye diseases carries benefits of specificity, scalability, and transportability, but their efficacy is significantly limited by a fast intraocular clearance rate. Ocular drug implants (ODIs) present a compe
Autor:
Cheng-Hui Lin, Yue Sun, Candace S.Y. Chan, Man-Ru Wu, Lei Gu, Alexander E. Davis, Baokun Gu, Wenlin Zhang, Bogdan Tanasa, Lei R. Zhong, Mark M. Emerson, Lu Chen, Jun B. Ding, Sui Wang
Publikováno v:
The Journal of biological chemistry. 298(4)
Adeno-associated viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, are highly cell-type-specific and can be integrated
Autor:
Lei R. Zhong, Alexander E. Davis, Mark M. Emerson, Cheng Hui Lin, Bogdan Tanasa, Yue Sun, Candace S.Y. Chan, Lu Chen, Man Ru Wu, Lei Gu, Jun B. Ding, Sui Wang
Publikováno v:
SSRN Electronic Journal.
Adeno Associated Viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, are highly cell type-specific and can be integrated