Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Man Lyang Kim"'
Autor:
Man Lyang Kim, Melinda Y. Hardy, Laura E. Edgington-Mitchell, Sri H. Ramarathinam, Shan Zou Chung, Amy K. Russell, Iain Currie, Brad E. Sleebs, Anthony W. Purcell, Jason A. Tye-Din, Ian P. Wicks
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103509- (2021)
Summary: Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antiox
Externí odkaz:
https://doaj.org/article/b4f7fa75e9d149f7bbd861a7d084ca17
Autor:
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby
Externí odkaz:
https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17158 (2011)
BACKGROUND: Nuclear factor-κB (NF-κB) is a transcription factor that regulates the transcription of genes involved in a variety of biological processes, including innate and adaptive immunity, stress responses and cell proliferation. Constitutive o
Externí odkaz:
https://doaj.org/article/4b91bad897a54a7aab7f4414e20a1601
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e15371 (2010)
BACKGROUND: During pathogen infection, innate immunity is initiated via the recognition of microbial products by pattern recognition receptors and the subsequent activation of transcription factors that upregulate proinflammatory genes. By controllin
Externí odkaz:
https://doaj.org/article/d0177b02f0f24da5961c252ad3931809
Autor:
Kathrin Thedieck, Pazit Polak, Man Lyang Kim, Klaus D Molle, Adiel Cohen, Paul Jenö, Cécile Arrieumerlou, Michael N Hall
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1217 (2007)
TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). In the p
Externí odkaz:
https://doaj.org/article/5d10bffc3d004f12b52f9f7f7214d0df
Hydroxychloroquine (HCQ) is a widely used and effective immunomodulatory drug. HCQ can cause dose-related retinal damage, thought to be due to inhibitory effects on lysosomes and autophagy. Using a human retinal pigment epithelial cell line (ARPE-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2aedbc2f649c307dbc21fc558700204
https://doi.org/10.21203/rs.3.rs-2299218/v1
https://doi.org/10.21203/rs.3.rs-2299218/v1
Autor:
Shan Zou Chung, Jason A. Tye-Din, Ian P. Wicks, Iain Currie, Sri H. Ramarathinam, Man Lyang Kim, Anthony W. Purcell, Amy K. Russell, Brad E. Sleebs, Laura E. Edgington-Mitchell, Melinda Y Hardy
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103509-(2021)
iScience, Vol 24, Iss 12, Pp 103509-(2021)
Summary Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antioxi
Autor:
Ian P. Wicks, Terence P. Speed, Guido Pacini, William J. Martin, Alexandra L. Garnham, Gordon K. Smyth, Man Lyang Kim, Jonathan R. Carapetis, Joanne Keeble, Gabriela Minigo
Publikováno v:
Circulation. 138:2648-2661
Background: Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection and remain major causes of cardiovascular morbidity and mortality around the world. Improved treatment has been stymied
Autor:
Malcolm J. McConville, Fernando Souza-Fonseca-Guimaraes, Motti Gerlic, Komal Kanojia, Adele Preaudet, Benjamin T. Kile, Marcel R. de Zoete, Man Lyang Kim, Konstantinos A. Kouremenos, Yasunori Ogura, Richard A. Flavell, David P De Souza, Cassandra R. Harapas, Tracy L Putoczki, Stephen Wilcox, Hazel Tye, Seth L. Masters, Graham L. Radford-Smith, Sinéad C. Corr, Martha Zakrzewski, Jocelyn Sietsma Penington, Leesa F. Wockner, Chien-Hsiung Yu, Anthony T. Papenfuss, Lisa A. Simms, Lisa A. Mielke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis b
Autor:
Dena Lyras, Hyun-Ja Ko, Ben A. Croker, Andrew W. Roberts, Seth L. Masters, Ladina DiRago, Hazel Tye, Benjamin T. Kile, Daniel L. Kastner, Louise H. Cengia, Andrew M. Lew, Dominic De Nardo, Donald Metcalf, Yong Hwan Park, Jae Jin Chae, Man Lyang Kim, Roslynn A. Stirzaker
Publikováno v:
The Journal of Experimental Medicine
Kim et al. identify an autoinflammatory disease in mice that is driven by IL-18, resulting from an inactivating mutation in the actin-depolymerizing cofactor Wdr1. This alteration in actin dynamics is recognized by the pyrin inflammasome and results