Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth.

Autor: Wang Y; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Gao B; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Tan PY; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Handoko YA; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Sekar K; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Deivasigamani A; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Seshachalam VP; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., OuYang HY; Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China., Shi M; Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China., Xie C; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Goh BKP; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore., Ooi LL; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore.; Division of Surgical Oncology, National Cancer Centre Singapore, Singapore., Man Hui K; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore.; Duke-NUS Medical School, Singapore.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Aug; Vol. 33 (8), pp. 8759-8770. Date of Electronic Publication: 2019 Apr 25.