Zobrazeno 1 - 10
of 829
pro vyhledávání: '"Man‑Fung Yuen"'
Autor:
Man-Fung Yuen, Wan-Long Chuang, Cheng-Yuan Peng, Wen-Juei Jeng, Wei-Wen Su, Ting-Tsung Chang, Chi-Yi Chen, Yao-Chun Hsu, Guy De La Rosa, Alaa Ahmad, Ed Luo, Annie L. Conery
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 3, Pp 375-387 (2024)
Background/Aims Oral EDP-514 is a potent core protein inhibitor of hepatitis B virus (HBV) replication, which produced a >4-log viral load reduction in HBV-infected chimeric mice with human liver cells. This study evaluated the safety, pharmacokineti
Externí odkaz:
https://doaj.org/article/ed2aee832b8041db91c2040ffaf8a503
Autor:
Jinlin Hou, Edward Gane, Rozalina Balabanska, Wenhong Zhang, Jiming Zhang, Tien Huey Lim, Qing Xie, Chau-Ting Yeh, Sheng-Shun Yang, Xieer Liang, Piyawat Komolmit, Apinya Leerapun, Zenghui Xue, Ethan Chen, Yuchen Zhang, Qiaoqiao Xie, Ting-Tsung Chang, Tsung-Hui Hu, Seng Gee Lim, Wan-Long Chuang, Barbara Leggett, Qingyan Bo, Xue Zhou, Miriam Triyatni, Wen Zhang, Man-Fung Yuen
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 2, Pp 191-205 (2024)
Background/Aims Four-week treatment of linvencorvir (RO7049389) was generally safe and well tolerated, and showed anti-viral activity in chronic hepatitis B (CHB) patients. This study evaluated the efficacy, safety, and pharmacokinetics of 48-week tr
Externí odkaz:
https://doaj.org/article/aeead632d03142ec95bc4b04123f5c17
Autor:
Tyng‐Yuan Jang, Po‐Cheng Liang, Dae Won Jun, Jang Han Jung, Hidenori Toyoda, Chih‐Wen Wang, Man‐Fung Yuen, Ka Shing Cheung, Satoshi Yasuda, Sung Eun Kim, Eileen L. Yoon, Jihyun An, Masaru Enomoto, Ritsuzo Kozuka, Makoto Chuma, Akito Nozaki, Toru Ishikawa, Tsunamasa Watanabe, Masanori Atsukawa, Taeang Arai, Korenobu Hayama, Masatoshi Ishigami, Yong Kyun Cho, Eiichi Ogawa, Hyoung Su Kim, Jae‐Jun Shim, Haruki Uojima, Soung Won Jeong, Sang Bong Ahn, Koichi Takaguchi, Tomonori Senoh, Maria Buti, Elena Vargas‐Accarino, Hiroshi Abe, Hirokazu Takahashi, Kaori Inoue, Jee‐Fu Huang, Wan‐Long Chuang, Ming‐Lun Yeh, Chia‐Yen Dai, Chung‐Feng Huang, Mindie H. Nguyen, Ming‐Lung Yu
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 2, Pp 188-197 (2024)
Abstract Elevated serum gamma‐glutamyl transferase (GGT) levels are associated with chronic hepatitis B (CHB)‐related hepatocellular carcinoma. However, their role in predicting mortality in patients with CHB treated with nucleotide/nucleoside an
Externí odkaz:
https://doaj.org/article/e34d44b81a6e43dbaa69ede33654fff2
Publikováno v:
F1000Research, Vol 13 (2024)
Advanced hepatocellular carcinoma (HCC) is traditionally associated with limited treatment options and a poor prognosis. Sorafenib, a multiple tyrosine kinase inhibitor, was introduced in 2007 as a first-in-class systemic agent for advanced HCC. Afte
Externí odkaz:
https://doaj.org/article/6ed9dec2e5e345eb89497562f4af2ba9
Autor:
Yu Chen, Lung-Yi Mak, Mary H.Y. Tang, Jingyi Yang, Chun Bong Chow, Ai-Ming Tan, Tao Lyu, Juan Wu, Qingjuan Huang, Hai-Bo Huang, Ka-Shing Cheung, Man-Fung Yuen, Wai-Kay Seto
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101050- (2024)
Background & Aims: Peripartum prophylaxis (PP) with tenofovir disoproxil fumarate (TDF) is the standard of care to prevent mother-to-child transmission of chronic hepatitis B (CHB) infection in mothers who are highly viremic. We investigated the mate
Externí odkaz:
https://doaj.org/article/1a48b04580e641f2a0e84784489839fe
Autor:
Saisai Zhang, Hau-Tak Chau, Hein Min Tun, Fung-Yu Huang, Danny Ka-Ho Wong, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105101- (2024)
Summary: Background: Gut dysbiosis is present in chronic hepatitis B virus (HBV) infection. In this study, we integrated microbiome and metabolome analysis to investigate the role of gut microbiome in virological response to nucleos(t)ide analogues (
Externí odkaz:
https://doaj.org/article/38380c530e3a449aa6cf857fb066824d
Autor:
Man-Fung Yuen, Scott Fung, Xiaoli Ma, Tuan T. Nguyen, Tarek Hassanein, Hie-Won Hann, Magdy Elkhashab, Ronald G. Nahass, James S. Park, Ira M. Jacobson, Walid S. Ayoub, Steven-Huy Han, Edward J. Gane, Katie Zomorodi, Ran Yan, Julie Ma, Steven J. Knox, Luisa M. Stamm, Maurizio Bonacini, Frank Weilert, Alnoor Ramji, Michael Bennett, Natarajan Ravendhran, Sing Chan, Douglas T. Dieterich, Paul Yien Kwo, Eugene R. Schiff, Ho S. Bae, Jacob Lalezari, Kosh Agarwal, Mark S. Sulkowski
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 100999- (2024)
Background & Aims: The investigational first-generation core inhibitor vebicorvir (VBR) demonstrated safety and antiviral activity over 24 weeks in two phase IIa studies in patients with chronic HBV infection. In this long-term extension study, patie
Externí odkaz:
https://doaj.org/article/79c1f480374a43d2b19433829b3f31b0
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background and Aim : In chronic hepatitis B infection (CHB), seroclearance of hepatitis B surface antigen (HBsAg) is associated with favourable clinical outcomes compared to those with persistent HBsAg seropositivity, and thus considered as
Externí odkaz:
https://doaj.org/article/77ad0844263d4263a3847f278f4c92fb
Autor:
Lung-Yi Mak, Albert CY Chan, Tiffany CL Wong, Wing-Chiu Dai, Wong-Hoi She, Ka-Wing Ma, Sui-Ling Sin, Ka-Wan Chu, Wai-Kay Seto, Man-Fung Yuen, Chung-Mau Lo, James Fung
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background & Aims Although non-alcoholic fatty liver disease (NAFLD) remains an uncommon indication for liver transplantation (LT) in the Chinese, the prevalence of NAFLD is increasing. We aimed to determine the prevalence of de novo steatos
Externí odkaz:
https://doaj.org/article/ccd63cc1f85e401087cef84177be3ef7
Autor:
Lok-Ka Lam, Thomas Sau Yan Chan, Yu-Yan Hwang, Lung-Yi Mak, Wai-Kay Seto, Yok-Lam Kwong, Man-Fung Yuen
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-4 (2023)
Abstract Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV inf
Externí odkaz:
https://doaj.org/article/cc05b311d10c40598f58c56123be4618