Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mamta Giri"'
Autor:
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and p
Externí odkaz:
https://doaj.org/article/9b4ce2bc11f1400dba2682d34318447c
Autor:
Joshua K. Morrison, Charles DeRossi, Isaac L. Alter, Shikha Nayar, Mamta Giri, Chi Zhang, Judy H. Cho, Jaime Chu
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1711-1724 (2022)
Abstract The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single
Externí odkaz:
https://doaj.org/article/90d3554613be407b84521a45ffda51e0
Autor:
Michael Ziemba, Molly Barkhouse, Kitipong Uaesoontrachoon, Mamta Giri, Yetrib Hathout, Utkarsh J Dang, Heather Gordish-Dressman, Kanneboyina Nagaraju, Eric P Hoffman
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246507 (2021)
Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the
Externí odkaz:
https://doaj.org/article/ce5d6cb03d0e4faca8116cb2ca183f89
Autor:
Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 8 (2019)
Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in viv
Externí odkaz:
https://doaj.org/article/92af79db91ab40a9b37d8885cb233256
Autor:
Maria J Gutierrez, Jose L Gomez, Geovanny F Perez, Krishna Pancham, Stephanie Val, Dinesh K Pillai, Mamta Giri, Sarah Ferrante, Robert Freishtat, Mary C Rose, Diego Preciado, Gustavo Nino
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162244 (2016)
BACKGROUND:Innate immune responses are fine-tuned by small noncoding RNA molecules termed microRNAs (miRs) that modify gene expression in response to the environment. During acute infections, miRs can be secreted in extracellular vesicles (EV) to fac
Externí odkaz:
https://doaj.org/article/01bf2310106e451b99d8e200819d0755
Autor:
Nai-Yun Hsu, Shikha Nayar, Kyle Gettler, Sayali Talware, Mamta Giri, Isaac Alter, Carmen Argmann, Ksenija Sabic, Tin Htwe Thin, Huai-Bin Mabel Ko, Robert Werner, Christopher Tastad, Thaddeus Stappenbeck, Aline Azabdaftari, Holm H Uhlig, Ling-Shiang Chuang, Judy H Cho
Publikováno v:
Gut. 72:654-662
ObjectiveLoss-of-function mutations in genes generating reactive oxygen species (ROS), such asNOX1, are associated with IBD. Mechanisms whereby loss of ROS drive IBD are incompletely defined.DesignROS measurements and single-cell transcriptomics were
Autor:
David R. Mack, Jarod Prince, Susan S. Baker, Brendan M. Boyle, Rebekah Karns, Suresh Venkateswaran, Subra Kugathasan, Talin Haritunians, Dermot P.B. McGovern, Mamta Giri, James Markowitz, Nai Yun Hsu, Melvin B. Heyman, Lee A. Denson, Ling-Shiang Chuang, Mayte Suárez-Fariñas, Greg Gibson, Jeffrey S. Hyams, Neal S. LeLeiko, Andrew Kasarskis, Kyle Gettler, Bruce J. Aronow, Cary G. Sauer, Yael Haberman, Carmen Argmann, Anne M. Griffiths, Joel R. Rosh, Nathan Gotman, Angela Mo, Dalia Arafat, Sapana Shah, Paul A. Rufo, Thomas D. Walters, Marian Pfefferkorn, Ashish S. Patel, Sonia Davis Thomas, Judy H. Cho, Robert N. Baldassano, Emebet Mengesha, Joshua D. Noe, Sini Nagpal
Publikováno v:
Am J Hum Genet
American journal of human genetics, vol 108, iss 9
American journal of human genetics, vol 108, iss 9
Summary An important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of individuals with ulcerative colitis (UC) require colectomy within 5 years of diagnosis, but polygenic risk scores (PR
Autor:
Yuval Itan, Mark S. Silverberg, Steven R. Brant, Ujunwa M. Korie, Aayushee Jain, Inga Peter, Shikha Nayar, Ling-Shiang Chuang, Talin Haritunians, Ksenija Sabic, John D. Rioux, Gerardus Bongers, Nicole Villaverde, Colleen C. Chasteau, Arden Moscati, Richard H. Duerr, Ernie Chen, Nai Yun Hsu, Tin Htwe Thin, Judy H. Cho, Sari Joshowitz, Isaac L. Alter, Siarhei Dzedzik, Zhi Chai, Mamta Giri, Kyle Gettler, L. Philip Schumm, Dermot P.B. McGovern
Publikováno v:
Gastroenterology
Background & Aims Recent literature has implicated a key role for mast cells in murine models of colonic inflammation, but their role in human ulcerative colitis (UC) is not well established. A major advance has been the identification of mrgprb2 (hu
Publikováno v:
ACS Symposium Series ISBN: 9780841298101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d06bbe8124ef240d6f5fc31d6a94448
https://doi.org/10.1021/bk-2021-1394.ch007
https://doi.org/10.1021/bk-2021-1394.ch007
Autor:
Shadi Nayeri, Dermot P.B. McGovern, Mamta Giri, Richard H. Duerr, Cristian Hernandez-Rocha, Jiayi Ji, Shikha Nayar, Ksenija Sabic, Steven R. Brant, Mark S. Silverberg, Phil Schumm, Margaret Walshe, Mark Lazarev, Liangyuan Hu, Judy H. Cho, John D. Rioux
Publikováno v:
J Crohns Colitis
Background and Aims Crohn’s disease [CD] recurrence following ileocolic resection [ICR] is common. We sought to identify blood-based biomarkers associated with CD recurrence. Methods CD patients undergoing ICR were recruited across six centres. Ser